Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Reddeppareddy Dandu"'
Autor:
Edward R. Bacon, Robert L. Hudkins, Thelma S. Angeles, Jennifer Grobelny, Mark S. Albom, Reddeppareddy Dandu, Bruce Ruggeri, Sheila J. Miknyoczki, Lisa D. Aimone, Shi Yang, Candy Robinson, Hong Chang, Allison L. Zulli, Ted L. Underiner
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:1916-1921
Fused dihydroindazolopyrrolocarbazole oximes have been identified as low nanomolar, potent dual TIE-2 and VEGF-R2 receptor tyrosine kinase inhibitors with excellent cellular potency. Development of the structure-activity relationships (SAR) led to id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff81dd5bd91b90c842800ca27629d74b
https://doi.org/10.1016/j.bmcl.2008.02.001
https://doi.org/10.1016/j.bmcl.2008.02.001
Publikováno v:
Journal of Heterocyclic Chemistry. 44:437-440
A regiospecific approach to each N-methyl-5-(1H-indol-2-yl)-6,7-dihydro-2H-indazole isomer is reported. The 1-methyl isomer 1 was prepared from 5-bromo-1-methyl-6,7-dihydro-1H-indazole 3 and indole-2-boronate 5 by palladium catalyzed Suzuki coupling.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26ae83c11a0204ca54c707fc677fb74c
https://doi.org/10.1002/jhet.5570440225
https://doi.org/10.1002/jhet.5570440225
Publikováno v:
Journal of Heterocyclic Chemistry. 43:719-722
This paper communicates the (regio) synthesis and a convenient NMR structural assignment method for N-methyl-tetrahydro-5H-indazol-5-one isomers. The cyclization reaction of 7-(hydroxymethylene)-1,4-dioxaspiro[4,5]decan-8-one (3) with methylhydrazine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1990deb581871769a8a6c3bf6b7f7d98
https://doi.org/10.1002/jhet.5570430328
https://doi.org/10.1002/jhet.5570430328
Publikováno v:
ChemInform. 38
A regiospecific approach to each N-methyl-5-(1H-indol-2-yl)-6,7-dihydro-2H-indazole isomer is reported. The 1-methyl isomer 1 was prepared from 5-bromo-1-methyl-6,7-dihydro-1H-indazole 3 and indole-2-boronate 5 by palladium catalyzed Suzuki coupling.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5988d04fdb2a90d07803ef567f17ac3e
https://doi.org/10.1002/chin.200732124
https://doi.org/10.1002/chin.200732124
Publikováno v:
ChemInform. 37
This paper communicates the (regio) synthesis and a convenient NMR structural assignment method for N-methyl-tetrahydro-5H-indazol-5-one isomers. The cyclization reaction of 7-(hydroxymethylene)-1,4-dioxaspiro[4,5]decan-8-one (3) with methylhydrazine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3c4728719300885b3780e7c232c6546
https://doi.org/10.1002/chin.200641106
https://doi.org/10.1002/chin.200641106