HTS and scRNA-seq revealed that the location and RSS quality of the mammalian TRBV and TRBJ genes impact biased rearrangement

Autor: Yingjie Wu, Fengli Wu, Qingqing Ma, Jun Li, Long Ma, Hou Zhou, Yadong Gong, Xinsheng Yao

Publikováno v: BMC Genomics, Vol 25, Iss 1, Pp 1-16 (2024)

Abstract The quality of Recombination signal sequences (RSSs), location, and genetics of mammalian V, D, and J genes synergistically affect the recombination frequency of genes; however, the specific regulatory mechanism and efficiency have not been

Externí odkaz: https://doaj.org/article/4400dea2c1cc4bc9802926bdd3af8367

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Characterization of the domestic goat γδ T cell receptor gene loci and gene usage

Autor: Janice C. Telfer, Al Yirsaw, Karthick P. Gunasekaran, Michael Turley, Timothy Connelley, Timothy P. L. Smith, Derek M. Bickhart, Cynthia L. Baldwin, Alexandria Gillespie

Publikováno v: Gillespie, A, Yirsaw, A, Gunasekaran, K P, Smith, T P, Bickhart, D M, Turley, M, Connelley, T, Telfer, J C & Baldwin, C L 2021, ' Characterization of the domestic goat γδ T cell receptor gene loci and gene usage ', Immunogenetics . https://doi.org/10.1007/s00251-021-01203-y

Goats and cattle diverged 30 million years ago but retain similarities in immune system genes. Here, the caprine T cell receptor (TCR) gene loci and transcription of its genes were examined and compared to cattle. We annotated the TCR loci using an i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0496a13eadd84aba9bc8de4f0c31628b
https://doi.org/10.1007/s00251-021-01203-y

V(DD)J recombination is an important and evolutionarily conserved mechanism for generating antibodies with unusually long CDR3s

Autor: Pavel A. Pevzner, Yana Safonova

Publikováno v: Genome Res

The V(DD)J recombination is currently viewed as an aberrant and inconsequential variant of the canonical V(D)J recombination. Moreover, since the classical 12/23 rule for the V(D)J recombination fails to explain the V(DD)J recombination, the molecula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca91f8d3fdc703f94053fc3778e75bbe
https://doi.org/10.1101/gr.259598.119

Functional requirement of terminal inverted repeats for efficient ProtoRAG activity reveals the early evolution of V(D)J recombination

Autor: Xinli Wang, Shaochun Yuan, Xin Tao, Wenjuan Yu, Song Liu, Ziwen Huang, Anlong Xu, Shangwu Chen, Fan Chen, Xiaoman Gao

Publikováno v: National Science Review

The discovery of ProtoRAG in amphioxus indicated that vertebrate RAG recombinases originated from an ancient transposon. However, the sequences of ProtoRAG terminal inverted repeats (TIRs) were obviously dissimilar to the consensus sequence of mouse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2c402308d0d72f99303a6a890b9586e
http://europepmc.org/articles/PMC8289069