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pro vyhledávání: '"Recombinant tumor necrosis factor"'
Akademický článek
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Autor:
Zhongyuan Guo, Lisha Liu, Yifei Lu, Chen Jiang, Xi He, Xinli Chen, Yongzhuo Huang, Tao Sun, Qin Guo, Yujie Zhang, Chao Li, Yu Zhang, Qinjun Chen
Publikováno v:
ACS Applied Materials & Interfaces. 11:23018-23025
Macromolecular protein drugs are promising anti-neoplastic agents based on their precise tumor affinity and innocuousness to normal tissues. Although direct delivery of protein drugs remains impractical due to its short half-life in circulation, inef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::119d246df30dbce921358a9284c0ed28
https://doi.org/10.1021/acsami.9b06097
https://doi.org/10.1021/acsami.9b06097
Publikováno v:
Iranian Journal of Biotechnology
Background: The tumor necrosis factor alpha (TNFα) is a cytokine that produced principally by monocyte/macrophages and T lymphocytes, respectively. TNFα is recognized as the primary mediator of immunity in inflammation reaction. One important appli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59df83804a4ad970e579128ab5ec688c
https://doi.org/10.21859/ijb.2153
https://doi.org/10.21859/ijb.2153
Autor:
Masashi Takaso, Mitsufumi Nakawaki, Tomonori Kenmoku, Kentaro Uchida, Naoshige Nagura, Gen Inoue
Publikováno v:
Journal of Shoulder and Elbow Surgery. 28:143-148
Background Nerve growth factor (NGF) plays a key role in osteoarthritic pain and low back pain. Rotator cuff tear (RCT) is often associated with severe shoulder pain. However, the role of NGF in RCT remains to be fully understood. Methods Rats were d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f19fa65a701ca27d9a853dd1ab0b2d4
https://doi.org/10.1016/j.jse.2018.06.030
https://doi.org/10.1016/j.jse.2018.06.030
Publikováno v:
Oncotarget
Activation of death receptor 5 (DR5) to induce apoptosis in cancer cells is an attractive strategy for cancer therapy. However, many tumor cell lines and primary tumors are resistant to DR5 targeted agents including recombinant tumor necrosis factor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78e4c61e62b5313baad40a275bbd92fa
https://doi.org/10.18632/oncotarget.26407
https://doi.org/10.18632/oncotarget.26407
Autor:
Adam Pennycuick, Neelam Kumar, Xidan Zhang, Mary Falzon, Krishna K. Kolluri, Ersilia Nigro, Yuki Ishii, Doraid Alrifai, Khalid Shah, Elaine Borg, Sam M. Janes
Publikováno v:
The Journal of Biological Chemistry
Malignant pleural mesothelioma (MPM) is a rare, aggressive, and incurable cancer arising from the mesothelial lining of the pleura, with few available treatment options. We recently reported that loss of function of the nuclear deubiquitinase BRCA1-a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b29ae2da35ab58c009cd489419063c2
https://pubmed.ncbi.nlm.nih.gov/34597666
https://pubmed.ncbi.nlm.nih.gov/34597666
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 1986 Jul . 83(14), 5233-5237.
Externí odkaz:
https://www.jstor.org/stable/27896
Autor:
Rossella Bertulli, Marco Fiore, Vittoria Colia, Gianpaolo Dagrada, Salvatore Provenzano, Paola Collini, Francesca Greco, Salvatore Lorenzo Renne, Paolo G. Casali, Alessandra Raimondi, Dario Callegaro
Publikováno v:
Clinical Sarcoma Research, Vol 7, Iss 1, Pp 1-6 (2017)
Clinical Sarcoma Research
Clinical Sarcoma Research
Background Ossifying fibromyxoid tumor (OFMT) is a rare soft tissue neoplasm of uncertain lineage and intermediate biological potential. It is more common in middle-aged men, usually arising from the deep tissues of the extremities. It is now establi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::443c82a15a34a574a9c9988c1ccdfc2c
http://link.springer.com/article/10.1186/s13569-017-0086-2
http://link.springer.com/article/10.1186/s13569-017-0086-2
Autor:
Chun-wai Suen, Jinfang Zhang, Jianxin Pang, Wei-Mao Wang, Lu Feng, Bao-hua Jiao, Ying-fei Lu, Shanshan Wang, Wei Guo, Weiming Fu, Bao-guang Hu
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 8, Iss, Pp 482-492 (2017)
Molecular Therapy. Nucleic Acids
Molecular Therapy. Nucleic Acids
Recombinant tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), as a novel cancer therapeutic, is being tested in phase II and III clinical trials; however, TRAIL resistance remains a big obstacle preventing its clinical applicatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::175a18f8d957c93476009139e1fff535
http://www.sciencedirect.com/science/article/pii/S2162253117302263
http://www.sciencedirect.com/science/article/pii/S2162253117302263
Publikováno v:
Drug Metabolism and Disposition. 45:790-797
The soluble cytokine tumor necrosis factor-α (TNF-α) is an important target for many therapeutic proteins used in the treatment of rheumatoid arthritis. Biologics targeting TNF-α exert their pharmacologic effects through binding and neutralizing t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c85f1fc73cd285a53185c89ce228542
https://doi.org/10.1124/dmd.116.074807
https://doi.org/10.1124/dmd.116.074807