Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Recombinant Nematode Anticoagulant Protein c2"'
Publikováno v:
Oncology Reports. 33:1815-1822
Nematode anticoagulant protein c2 (NAPc2) is an 85-residue polypeptide originally isolated from the hema - tophagous hookworm, Ancylostoma caninum. Several studies have shown that rNAPc2 inhibits the growth of primary and metastatic tumors in mice in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a780f0966c2dce8f1372503bf029c5a
https://doi.org/10.3892/or.2015.3795
https://doi.org/10.3892/or.2015.3795
Autor:
Lina W Assad, Tarek Owaidah, Engin Baturcam, Mohammed Dehbi, Abdelmoneim Eldali, Falah Al-Mohanna, Abderrezak Bouchama
Publikováno v:
Critical Care Medicine. 40:1229-1236
OBJECTIVE Excessive activation of coagulation, which can culminate in overt disseminated intravascular coagulation, is a prominent feature of heat stroke. However, neither the mechanism that initiates the coagulation activation nor its pathogenic rol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d040647d1830aeae5fef2731088f8f3
https://doi.org/10.1097/ccm.0b013e3182387bef
https://doi.org/10.1097/ccm.0b013e3182387bef
Publikováno v:
Clinical Cancer Research. 15:208-216
Purpose: Recombinant nematode anticoagulant protein c2 (rNAPc2) is a specific inhibitor of tissue factor (TF)/factor VIIa complex with novel antithrombotic activity. TF is highly expressed in human colorectal tumors, and levels are positively correla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb16dc8bba02a44de17ce364109a4099
https://doi.org/10.1158/1078-0432.ccr-08-0407
https://doi.org/10.1158/1078-0432.ccr-08-0407
Autor:
Peter Stone, Robert P. Giugliano, Steven R. Deitcher, Alain Bouchard, Daniel I. Simon, Eugene Braunwald, Stephen D. Wiviott, Massoud A. Leesar, Anthem–Timi Investigators, Marc J. Schweiger, Carolyn H. McCabe, Michael A Goulder
Publikováno v:
Journal of the American College of Cardiology. 49(25):2398-2407
Objectives We sought to evaluate the safety and efficacy of recombinant nematode anticoagulant protein c2 (rNAPc2) in patients with non–ST-segment elevation acute coronary syndrome (nSTE-ACS). Background Recombinant NAPc2 is a potent inhibitor of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0b1d47b05a2897c98430bd72859844f
Autor:
Marcel Levi, George P. Vlasuk, Anne-Cornélie J. M. de Pont, Joost C. M. Meijers, Harry R. Büller, Kamran Bakhtiari, William E. Rote, Barbara A. Hutten, Evert de Jonge
Publikováno v:
British journal of haematology, 134(2), 213-219. Wiley-Blackwell
Summary Systemic inflammation activates the tissue factor/factor VIIa complex (TF/FVIIa), leading to a procoagulant state, which may be enhanced by impairment of physiological anticoagulant pathways, such as the protein C system. Besides impaired pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e7d84868dc2d7de43d155e31bf2c371
https://doi.org/10.1111/j.1365-2141.2006.06127.x
https://doi.org/10.1111/j.1365-2141.2006.06127.x
Autor:
George P. Vlasuk, E. de Jonge, A H M Moons, William E. Rote, H. R. Büller, T. van der Poll, A C J M de Pont, Joost C. M. Meijers, Marcel Levi
Publikováno v:
Journal of thrombosis and haemostasis, 2(1), 65-70. Wiley-Blackwell
The tissue factor-factor (F)VIIa complex (TF/FVIIa) is responsible for the initiation of blood coagulation under both physiological and pathological conditions. Recombinant nematode anticoagulant protein c2 (rNAPc2) is a potent inhibitor of TF/FVIIa.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8f398b674e65514b92545013dbc258e
https://doi.org/10.1111/j.1538-7836.2004.00526.x
https://doi.org/10.1111/j.1538-7836.2004.00526.x
Autor:
George P. Vlasuk, Ron J.G. Peters, Nick R. Bijsterveld, Martin H. Prins, William E. Rote, Arno H.M. Moons, Harry R. Büller, Jan J. Piek
Publikováno v:
Journal of the American College of Cardiology, 41(12), 2147-2153. Elsevier USA
OBJECTIVES We investigated the safety and pharmacodynamics of escalating doses of recombinant nematode anticoagulant protein c2 (rNAPc2) in patients undergoing elective coronary angioplasty. BACKGROUND Recombinant NAPc2 is a potent inhibitor of the t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8317c4e1791841627318a1d7cf1e8d1c
https://doi.org/10.1016/s0735-1097(03)00478-9
https://doi.org/10.1016/s0735-1097(03)00478-9
Publikováno v:
Future cardiology. 3(4)
Patients with acute coronary syndromes (ACS) have high recurrent ischemic event rates despite management with current guideline-based therapies. Recombinant nematode anticoagulant protein (rNAP)c2 provides factor Xa-dependent inhibition of the tissue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1e7f73cd8ef2a8b8178b09179d0ba8d
https://pubmed.ncbi.nlm.nih.gov/19804227
https://pubmed.ncbi.nlm.nih.gov/19804227
Autor:
Lisa E. Hensley, Tom Larsen, Elizabeth A. Fritz, Kathleen M. Daddario-DiCaprio, Pierre Formenty, Thomas W. Geisbert, Joan B. Geisbert, Howard A. Young
Publikováno v:
The Journal of Infectious Diseases
Background. The procoagulant tissue factor (TF) is thought to play a role in the coagulation disorders that characterize filoviral infections. In this study, we evaluated the pathogenesis of lethal infection with the Angola strain of Marburg virus (M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e976b5dab5233a003662f18d3ac65b7
https://pubmed.ncbi.nlm.nih.gov/17940973
https://pubmed.ncbi.nlm.nih.gov/17940973
Autor:
Nick R. Bijsterveld, Sam Schulman
Publikováno v:
Transfusion medicine reviews. 21(1)
In an exciting era with many alternatives to the old anticoagulants heparin and warfarin emerging on the scene, awareness of the possibility to reverse their effect is mandatory. In this review, the traditional antidotes for warfarin (vitamin K, plas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d1e267074fff577d6a9878ccccc38e2
https://pubmed.ncbi.nlm.nih.gov/17174219
https://pubmed.ncbi.nlm.nih.gov/17174219