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pro vyhledávání: '"Recombinant Fusion Proteins/administration & dosage/analysis/immunology"'
Autor:
Anne-Françoise Rochat, Claire-Anne Siegrist, Karen Lingnau, Else Marie Agger, Arun T. Kamath, Paul-Henri Lambert, Mario Paolo Valenti, Alexander von Gabain, Peter Andersen
Publikováno v:
European Journal of Immunology, Vol. 38, No 5 (2008) pp. 1247-56
Vaccine efficacy largely depends upon DC targeting and activation. The most potent TLR soluble ligands induce diffuse DC activation, which may be associated with marked pro-inflammatory responses and possibly adverse effects. This raises the concern