Myeloid cells protect intestinal epithelial barrier integrity through the angiogenin/plexin‐B2 axis

Autor: Zhengping Xu, Zhengrong Yao, Xiaolong Ge, Xiaoliang Shi, Yaxin Liu, Xiangwei Gao, Guo-fu Hu, Rongpan Bai, Desen Sun, Liang Luo, Muxiong Chen, Wei Zhou, Jinghao Sheng

Publikováno v: EMBO J

Communication between myeloid cells and epithelium plays critical role in maintaining intestinal epithelial barrier integrity. Myeloid cells interact with intestinal epithelial cells (IECs) by producing various mediators; however, the molecules media

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb14afc0234a901b2a04ef92360c511a
https://doi.org/10.15252/embj.2019103325

Angiogenin Attenuates Scar Formation in Burn Patients by Reducing Fibroblast Proliferation and Transforming Growth Factor β1 Secretion

Autor: Shin Chen Pan, Wei Yu Fang, Chou Hwei Lee, Chung-Lin Chen, Li Wha Wu

Publikováno v: Annals of Plastic Surgery. 80:S79-S83

Background Deep burn wounds have a high tendency to form hypertrophic scars. Previously, we found that angiogenin promoted neovascularization during deep burn wound healing. However, the association between angiogenin and scar formation is unclear. M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd318788305949b7099b0295d0c6c817
https://doi.org/10.1097/sap.0000000000001306

Copper binding to naturally occurring, lactam form of angiogenin differs from that to recombinant protein, affecting their activity

Autor: Giovanni Natile, Örjan Hansson, M.L. Trincavelli, Fabio Arnesano, Vincenzo Mangini, Claudia Martini, Francesco Bellia, D La Mendola, Chiara Giacomelli, Enrico Rizzarelli, A Magrì, Vincenza Calò

Publikováno v: Metallomics
8 (2016): 118–124. doi:10.1039/c5mt00216h
info:cnr-pdr/source/autori:La Mendola, D.; Arnesano, F.; Hansson, O.; Giacomelli, C.; Calo, V.; Mangini, V.; Magri, A.; Bellia, F.; Trincavelli, M. L.; Martini, C.; Natile, G.; Rizzarelli, E./titolo:Copper binding to naturally occurring, lactam form of angiogenin differs from that to recombinant protein, affecting their activity/doi:10.1039%2Fc5mt00216h/rivista:Metallomics (Print)/anno:2016/pagina_da:118/pagina_a:124/intervallo_pagine:118–124/volume:8

Angiogenin is a member of the ribonuclease family and a normal constituent of human plasma. It is one of the most potent angiogenic factors known and is overexpressed in different types of cancers. Copper is also an essential cofactor in angiogenesis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ee791b1e838aa2b0dbbd5c9ed37d783
https://doi.org/10.1039/c5mt00216h

Angiogenin cleaves tRNA and promotes stress-induced translational repression

Autor: Guo-fu Hu, Pavel Ivanov, Satoshi Yamasaki, Paul A. Anderson

Publikováno v: The Journal of Cell Biology

Stress-induced phosphorylation of eIF2α inhibits global protein synthesis to conserve energy for repair of stress-induced damage. Stress-induced translational arrest is observed in cells expressing a nonphosphorylatable eIF2α mutant (S51A), which i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d75a91e0db105f8503aea9cbfd306f58
http://europepmc.org/articles/PMC2700517

Secretion of functional anti-CD30-angiogenin immunotoxins into the supernatant of transfected 293T-cells

Autor: Anne Krüssmann, S. Sasse, Stefan Barth, Michael Stöcker, Andreas Engert, Mehmet Kemal Tur

Publikováno v: Protein Expression and Purification. 28:211-219

Immunotoxins consist of a target-cell-specific binding moiety, chemically or recombinantly linked to a cytotoxic component. A number of different immunotoxins (IT) have increasingly been evaluated for immunotherapy. Since these foreign proteins are h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfd7c347c411d79fdf003dc21535c5dc
https://doi.org/10.1016/s1046-5928(02)00709-x