Integrating Phenotypic Search and Phosphoproteomic Profiling of Active Kinases for Optimization of Drug Mixtures for RCC Treatment.

Autor: van Beijnum JR; Angiogenesis Laboratory, Department of Medical Oncology, Amsterdam UMC, Vrije Universiteit Amsterdam, Medical Oncology, Cancer Center Amsterdam, De Boelelaan 1117, 1081HV, 1182 DB Amsterdam, The Netherlands., Weiss A; Molecular Pharmacology Group, School of Pharmaceutical Sciences, University of Geneva, 1211 Geneva, Switzerland.; Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, 1211 Geneva, Switzerland., Berndsen RH; Angiogenesis Laboratory, Department of Medical Oncology, Amsterdam UMC, Vrije Universiteit Amsterdam, Medical Oncology, Cancer Center Amsterdam, De Boelelaan 1117, 1081HV, 1182 DB Amsterdam, The Netherlands.; Molecular Pharmacology Group, School of Pharmaceutical Sciences, University of Geneva, 1211 Geneva, Switzerland., Wong TJ; Angiogenesis Laboratory, Department of Medical Oncology, Amsterdam UMC, Vrije Universiteit Amsterdam, Medical Oncology, Cancer Center Amsterdam, De Boelelaan 1117, 1081HV, 1182 DB Amsterdam, The Netherlands., Reckman LC; Angiogenesis Laboratory, Department of Medical Oncology, Amsterdam UMC, Vrije Universiteit Amsterdam, Medical Oncology, Cancer Center Amsterdam, De Boelelaan 1117, 1081HV, 1182 DB Amsterdam, The Netherlands., Piersma SR; Department of Medical Oncology, Amsterdam UMC, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, De Boelelaan 1117, 1081HV, 1182 DB Amsterdam, The Netherlands.; OncoProteomics Laboratory, Amsterdam UMC, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, 1081 HV Amsterdam, The Netherlands., Zoetemelk M; Molecular Pharmacology Group, School of Pharmaceutical Sciences, University of Geneva, 1211 Geneva, Switzerland.; Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, 1211 Geneva, Switzerland., de Haas R; Angiogenesis Laboratory, Department of Medical Oncology, Amsterdam UMC, Vrije Universiteit Amsterdam, Medical Oncology, Cancer Center Amsterdam, De Boelelaan 1117, 1081HV, 1182 DB Amsterdam, The Netherlands.; Department of Medical Oncology, Amsterdam UMC, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, De Boelelaan 1117, 1081HV, 1182 DB Amsterdam, The Netherlands.; OncoProteomics Laboratory, Amsterdam UMC, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, 1081 HV Amsterdam, The Netherlands., Dormond O; Department of Visceral surgery, Lausanne University Hospital and University of Lausanne, 1015 Lausanne, Switzerland., Bex A; Royal Free London NHS Foundation Trust, Renal Cancer Centre, University College London, Division of Surgical and Interventional Science, London NW3 2QG, UK.; Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands., Henneman AA; Department of Medical Oncology, Amsterdam UMC, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, De Boelelaan 1117, 1081HV, 1182 DB Amsterdam, The Netherlands.; OncoProteomics Laboratory, Amsterdam UMC, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, 1081 HV Amsterdam, The Netherlands., Jimenez CR; Department of Medical Oncology, Amsterdam UMC, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, De Boelelaan 1117, 1081HV, 1182 DB Amsterdam, The Netherlands.; OncoProteomics Laboratory, Amsterdam UMC, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, 1081 HV Amsterdam, The Netherlands., Griffioen AW; Angiogenesis Laboratory, Department of Medical Oncology, Amsterdam UMC, Vrije Universiteit Amsterdam, Medical Oncology, Cancer Center Amsterdam, De Boelelaan 1117, 1081HV, 1182 DB Amsterdam, The Netherlands., Nowak-Sliwinska P; Molecular Pharmacology Group, School of Pharmaceutical Sciences, University of Geneva, 1211 Geneva, Switzerland.; Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, 1211 Geneva, Switzerland.; Translational Research Centre in Oncohaematology, 1211 Geneva, Switzerland.

Publikováno v: Cancers [Cancers (Basel)] 2020 Sep 21; Vol. 12 (9). Date of Electronic Publication: 2020 Sep 21.