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Akademický článek

Structure-Activity Relationships and Molecular Pharmacology of Positive Allosteric Modulators of the Mu-Opioid Receptor.

Autor: Li M; Edward F Domino Research Center, Department of Pharmacology, University of Michigan, Ann Arbor, Michigan 48109, United States., Gan X; Vahlteich Medicinal Chemistry Core, University of Michigan, Ann Arbor, Michigan 48109, United States., Liu K; Vahlteich Medicinal Chemistry Core, University of Michigan, Ann Arbor, Michigan 48109, United States., Walajapet R; Vahlteich Medicinal Chemistry Core, University of Michigan, Ann Arbor, Michigan 48109, United States., Stanczyk MA; Edward F Domino Research Center, Department of Pharmacology, University of Michigan, Ann Arbor, Michigan 48109, United States., Stewart HC; Edward F Domino Research Center, Department of Pharmacology, University of Michigan, Ann Arbor, Michigan 48109, United States., Rech JC; Vahlteich Medicinal Chemistry Core, University of Michigan, Ann Arbor, Michigan 48109, United States.; Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109, United States., White AD; Vahlteich Medicinal Chemistry Core, University of Michigan, Ann Arbor, Michigan 48109, United States.; Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109, United States., Traynor JR; Edward F Domino Research Center, Department of Pharmacology, University of Michigan, Ann Arbor, Michigan 48109, United States.; Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109, United States.

Publikováno v: ACS chemical neuroscience [ACS Chem Neurosci] 2024 Dec 11. Date of Electronic Publication: 2024 Dec 11.

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Akademický článek

Studies of Structure-Activity Relationship of 2-(Pyrrolidin-1ylmethyl)-1 H -pyrrole-Based ST2 Inhibitors and Their Inhibition of Mast Cells Activation.

Autor: Yuan X; Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee 38163, United States., Rech JC; Department of Internal Medicine, Hematology and Oncology, Michigan Center for Therapeutic Innovation, Ann Arbor, Michigan 48109, United States., Ramaraju A; Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee 38163, United States., Patil AD; Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee 38163, United States., Rajanayake K; College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109, United States., Yuan H; College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109, United States., Kazemi Sabzvar M; Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee 38163, United States., Mandal M; Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee 38163, United States., Cho EB; Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee 38163, United States., Wen B; College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109, United States., Jiang J; Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee 38163, United States., Leo MD; Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee 38163, United States., Singh UP; Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee 38163, United States., Sun D; College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109, United States., Yang CY; Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee 38163, United States.

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2024 Oct 18; Vol. 15 (11), pp. 2053-2059. Date of Electronic Publication: 2024 Oct 18 (Print Publication: 2024).

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Akademický článek

Can Machine Learning Overcome the 95% Failure Rate and Reality that Only 30% of Approved Cancer Drugs Meaningfully Extend Patient Survival?

Autor: Sun D, Macedonia C; Lancaster Life Science Group, Lancaster, Pennsylvania 17601, United States., Chen Z; LabBotics.ai, Palo Alto, California 94303, United States., Chandrasekaran S, Najarian K, Zhou S; Aurinia Pharmaceuticals Inc., Rockville, Maryland 20850, United States., Cernak T, Ellingrod VL, Jagadish HV, Marini B, Pai M, Violi A, Rech JC, Wang S, Li Y; Translational Medicine and Clinical Pharmacology, Bristol Myers Squibb, Summit, New Jersey 07901, United States., Athey B, Omenn GS

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2024 Sep 26; Vol. 67 (18), pp. 16035-16055. Date of Electronic Publication: 2024 Sep 10.

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Akademický článek

Prophylactic Mitigation of Acute Graft versus Host Disease by Novel 2-(Pyrrolidin-1-ylmethyl)pyrrole-Based Stimulation-2 (ST2) Inhibitors.

Autor: Yuan X; Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee 38163, United States., Jiang H; Department of Microbiology & Immunology, Medical University of South Carolina, Charleston, South Carolina 29425-2503, United States., Fu D; Department of Microbiology & Immunology, Medical University of South Carolina, Charleston, South Carolina 29425-2503, United States., Rech JC; Michigan Center for Therapeutic Innovation, Department of Internal Medicine, Life Sciences Institute, Department of Pharmaceutical Sciences, College of Pharmacy, and Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan 48109, United States., Robida A; Michigan Center for Therapeutic Innovation, Department of Internal Medicine, Life Sciences Institute, Department of Pharmaceutical Sciences, College of Pharmacy, and Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan 48109, United States., Rajanayake K; Michigan Center for Therapeutic Innovation, Department of Internal Medicine, Life Sciences Institute, Department of Pharmaceutical Sciences, College of Pharmacy, and Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan 48109, United States., Yuan H; Michigan Center for Therapeutic Innovation, Department of Internal Medicine, Life Sciences Institute, Department of Pharmaceutical Sciences, College of Pharmacy, and Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan 48109, United States., He M; Michigan Center for Therapeutic Innovation, Department of Internal Medicine, Life Sciences Institute, Department of Pharmaceutical Sciences, College of Pharmacy, and Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan 48109, United States., Wen B; Michigan Center for Therapeutic Innovation, Department of Internal Medicine, Life Sciences Institute, Department of Pharmaceutical Sciences, College of Pharmacy, and Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan 48109, United States.; Michigan Center for Therapeutic Innovation, Department of Internal Medicine, Life Sciences Institute, Department of Pharmaceutical Sciences, College of Pharmacy, and Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan 48109, United States., Sun D; Michigan Center for Therapeutic Innovation, Department of Internal Medicine, Life Sciences Institute, Department of Pharmaceutical Sciences, College of Pharmacy, and Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan 48109, United States.; Michigan Center for Therapeutic Innovation, Department of Internal Medicine, Life Sciences Institute, Department of Pharmaceutical Sciences, College of Pharmacy, and Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan 48109, United States., Liu C; Department of Pathology, Yale University, New Haven, Connecticut 06520, United States., Chinnaswamy K; Michigan Center for Therapeutic Innovation, Department of Internal Medicine, Life Sciences Institute, Department of Pharmaceutical Sciences, College of Pharmacy, and Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan 48109, United States.; Michigan Center for Therapeutic Innovation, Department of Internal Medicine, Life Sciences Institute, Department of Pharmaceutical Sciences, College of Pharmacy, and Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan 48109, United States., Stuckey JA; Michigan Center for Therapeutic Innovation, Department of Internal Medicine, Life Sciences Institute, Department of Pharmaceutical Sciences, College of Pharmacy, and Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan 48109, United States.; Michigan Center for Therapeutic Innovation, Department of Internal Medicine, Life Sciences Institute, Department of Pharmaceutical Sciences, College of Pharmacy, and Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan 48109, United States., Paczesny S; Department of Microbiology & Immunology, Medical University of South Carolina, Charleston, South Carolina 29425-2503, United States., Yang CY; Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee 38163, United States.

Publikováno v: ACS pharmacology & translational science [ACS Pharmacol Transl Sci] 2023 Aug 16; Vol. 6 (9), pp. 1275-1287. Date of Electronic Publication: 2023 Aug 16 (Print Publication: 2023).

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Akademický článek

Development of Novel Small-Molecule Activators of Pyruvate Kinase Muscle Isozyme 2, PKM2, to Reduce Photoreceptor Apoptosis.

Autor: Wubben TJ; Department of Ophthalmology and Visual Sciences, Kellogg Eye Center, University of Michigan, Ann Arbor, MI 48105, USA., Chaudhury S; Department of Ophthalmology and Visual Sciences, Kellogg Eye Center, University of Michigan, Ann Arbor, MI 48105, USA., Watch BT; Department of Internal Medicine, Hematology and Oncology, Michigan Center for Therapeutic Innovation, University of Michigan, Ann Arbor, MI 48109, USA., Stuckey JA; Departments of Biological Chemistry and Biophysics, Center for Structural Biology, University of Michigan, Ann Arbor, MI 48109, USA., Weh E; Department of Ophthalmology and Visual Sciences, Kellogg Eye Center, University of Michigan, Ann Arbor, MI 48105, USA., Fernando R; Department of Ophthalmology and Visual Sciences, Kellogg Eye Center, University of Michigan, Ann Arbor, MI 48105, USA., Goswami M; Department of Ophthalmology and Visual Sciences, Kellogg Eye Center, University of Michigan, Ann Arbor, MI 48105, USA., Pawar M; Department of Ophthalmology and Visual Sciences, Kellogg Eye Center, University of Michigan, Ann Arbor, MI 48105, USA., Rech JC; Department of Internal Medicine, Hematology and Oncology, Michigan Center for Therapeutic Innovation, University of Michigan, Ann Arbor, MI 48109, USA., Besirli CG; Department of Ophthalmology and Visual Sciences, Kellogg Eye Center, University of Michigan, Ann Arbor, MI 48105, USA.

Publikováno v: Pharmaceuticals (Basel, Switzerland) [Pharmaceuticals (Basel)] 2023 May 06; Vol. 16 (5). Date of Electronic Publication: 2023 May 06.

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