PPARs as Key Mediators in the Regulation of Metabolism and Inflammation

Autor: Manuel Vazquez-Carrera, Walter Wahli

Publikováno v: International journal of molecular sciences, vol. 23, no. 9, pp. 5025

Nuclear receptors (NRs) form a large family of ligand-dependent transcription factors that control the expression of a multitude of genes involved in diverse, vital biological processes. Three of these receptors, the peroxisome proliferator-activated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7981f60d22dafde4984a39914c79b5d
http://hdl.handle.net/2445/191386

GDF15 mediates the metabolic effects of PPARβ/δ by activating AMPK

Autor: David Aguilar-Recarte, Xavier Palomer, Lucía Peña, Anna Gumà, Javier Pizarro-Delgado, Walter Wahli, Maria Ruart, Emma Barroso, Manuel Vázquez-Carrera

Publikováno v: Cell Reports
Cell Reports, Elsevier Inc, 2021, 36 (6), ⟨10.1016/j.celrep.2021.109501⟩
Dipòsit Digital de la UB
Universidad de Barcelona
Cell Reports, Vol 36, Iss 6, Pp 109501-(2021)

Peroxisome proliferator-activated receptor β/ (PPARβ/) activates AMP-activated protein kinase (AMPK) and plays a crucial role in glucose and lipid metabolism. Here, we examined whether the beneficial effects of PPARβ/δ activation depended o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f1334a82a9c5dac73149edeb5da2013
https://hal.inrae.fr/hal-03321289

El receptor nuclear NOR-1 en el remodelado cardiovascular: análisis de mecanismos fisiopatológicos y validación de nuevos modelos animales de utilidad preclínica

Autor: Cañes Esteve, Laia

Publikováno v: Dipòsit Digital de la UB
Universidad de Barcelona
TDX (Tesis Doctorals en Xarxa)
TDR. Tesis Doctorales en Red
instname

[spa] Actualmente no se dispone de fármacos eficaces ni de modelos animales adecuados para estudiar el aneurisma de la aorta abdominal (AAA) ni la hipertrofia cardiaca, patologías con una elevada morbi-mortalidad. La expresión del receptor nuclear

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::802ccd8ae9cb5d6393dc6c881a4f1bb2
http://hdl.handle.net/2445/184549

An Esrrb and nanog cell fate regulatory module controlled by feed forward loop interactions

Autor: Ana Sevilla, Dimitri Papatsenko, Amin R. Mazloom, Huilei Xu, Ana Vasileva, Richard D. Unwin, Gary LeRoy, Edward Y. Chen, Francine E. Garrett-Bakelman, Dung-Fang Lee, Benjamin Trinite, Ryan L. Webb, Zichen Wang, Jie Su, Julian Gingold, Ari Melnick, Benjamin A. Garcia, Anthony D. Whetton, Ben D. MacArthur, Avi Ma’ayan, Ihor R. Lemischka

Publikováno v: Dipòsit Digital de la UB
Universidad de Barcelona
Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname

Cell fate decisions during development are governed by multi-factorial regulatory mechanisms including chromatin remodeling, DNA methylation, binding of transcription factors to specific loci, RNA transcription and protein synthesis. However, the mec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccc6fa98c878d13579ed2b10c36df178
http://hdl.handle.net/2445/176522

Compound F: A novel nuclear receptor modulator and its potential application on hematologic malignancies

Autor: Ruiz Cánovas, Eugenia

Publikováno v: Dipòsit Digital de la UB
Universidad de Barcelona
TDX (Tesis Doctorals en Xarxa)
TDR. Tesis Doctorales en Red
instname

[eng] Compound F has been reported to possess important antioxidant, anti-inflammatory, anti- diabetic and anti-cancer effects, among other interesting properties. Although Compound F has been extensively investigated, its underlying mechanism of act

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::07847bdffb94bf1ed80ba6d73b6f51c5
http://hdl.handle.net/2445/132282