Výsledky vyhledávání - "Receptors, Tumor Necrosis Factor/ physiology"

The Tumor Suppressor CYLD Interacts with TRIP and Regulates Negatively Nuclear Factor κB Activation by Tumor Necrosis Factor

Autor: Jia Wei Liu, Rune Toftgård, Marcel Huber, Alexandre Regamey, Priit Kogerman, Daniel Hohl, Thierry Roger

Publikováno v: The Journal of Experimental Medicine
Journal of Experimental Medicine, vol. 198, no. 12, pp. 1959-64

Cylindromas are benign adnexal skin tumors caused by germline mutations in the CYLD gene. In most cases the second wild-type allele is lost in tumor tissue, suggesting that CYLD functions as tumor suppressor. CYLD is a protein of 956 amino acids harb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b97c1cadaf3d773cd1bb4938049fd1f5
http://europepmc.org/articles/PMC2194148

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Both TNF receptors are required for direct TNF‐mediated cytotoxicity in microvascular endothelial cells

Autor: Rudolf Lucas, Gabriel Núñez, Georges E. Grau, Michael S. Pepper, Wim A. Buurman, Christine Giroud, Yves Donati, Lucie Fransen, Peter M. Suter, Marusa Hribar, Irene Garcia, Stefano J. Mandriota

Publikováno v: European Journal of Immunology, 28(11), 3577-3586. Wiley
European Journal of Immunology, Vol. 28, No 11 (1998) pp. 3577-3586

Department of Anaesthesiology, Pharmacology and Surgical Intensive Care, University Medical Center, University of Geneva, Switzerland. lucas@cmu.unige.chThe conditions under which tumor necrosis factor-alpha (TNF) induces apoptosis in primary microva

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::913c38545717d7d2aef15e9610d62eb0
https://doi.org/10.1002/(sici)1521-4141(199811)28:11<3577::aid-immu3577>3.0.co

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Transgenic mice expressing soluble tumor necrosis factor-receptor are protected against bone loss caused by estrogen deficiency

Autor: S. Bourrin, René Rizzoli, Irène Garcia, Pierre Vassalli, Jean-Marc Meyer, Jean-Philippe Bonjour, Patrick Ammann

Publikováno v: Journal of Clinical Investigation, Vol. 99, No 7 (1997) pp. 1699-1703

To evaluate the role of tumor necrosis factor (TNF alpha) in bone loss resulting from estrogen deficiency, the effects of ovariectomy were explored in six-month-old transgenic mice expressing high blood levels of a soluble TNF receptor type I (sTNFR1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a2efb695ed030cc1086f05de849c8a0
https://doi.org/10.1172/jci119333

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The Amaryllidaceae isocarbostyril narciclasine induces apoptosis by activation of the death receptor and/or mitochondrial pathways in cancer cells but not in normal fibroblasts

Autor: Francis Darro, Robert Kiss, Fabrice Ribaucour, Patrick Dumont, Florence Lefranc, Isabelle Roland, Laurent Ingrassia, Stéphanie Thomas, Sébastien Rouzeau

Publikováno v: NeoPlasia : an international journal of oncology research, Vol. 9, no. 9, p. 766-776 (2007)
Neoplasia: An International Journal for Oncology Research, Vol 9, Iss 9, Pp 766-776 (2007)

Our study has shown that the Amaryllidaceae isocarbostyril narciclasine induces marked apoptosismediated cytotoxic effects in human cancer cells but not in normal fibroblasts by triggering the activation of the initiator caspases of the death recepto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::877d4a9d4a9b3b4c340eeb576cc8f6ac
https://hdl.handle.net/2078.1/89964

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Soluble TNF receptors partially protect injured motoneurons in the postnatal CNS

Autor: Terrado, J., Monnier, D., Perrelet, D., Vesin, D., Jemelin, S., Buurman, W.A., Mattenberger, L., King, B., Kato, A.C., Garcia, I.

Publikováno v: European Journal of Neuroscience, Vol. 12, No 9 (2000) pp. 3443-3447
European Journal of Neuroscience, 12, 3443-3447. Wiley

There is accumulating evidence that cytokines are involved in the functioning of the brain and the spinal cord. However, it has been controversial whether they exert a neurotoxic or a neuroprotective effect. To address this question in vivo, we have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f77b608df50ae49610cb4b6b5730aef0
https://archive-ouverte.unige.ch/unige:11354

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TWEAK can induce cell death via endogenous TNF and TNF receptor 1

Autor: P, Schneider, R, Schwenzer, E, Haas, F, Mühlenbeck, G, Schubert, P, Scheurich, J, Tschopp, H, Wajant

Publikováno v: European Journal of Immunology, vol. 29, no. 6, pp. 1785-1792

TWEAK is a recently cloned novel member of the TNF ligand family. Here we show that soluble TWEAK is sufficient to induce apoptosis in Kym-1 cells within 18 h. TWEAK-induced apoptosis is indirect and is mediated by the interaction of endogenous TNF a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ec572819160ec18d677cbc404aa02527
https://serval.unil.ch/notice/serval:BIB_C46EED5E330C

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BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth

Autor: Sarah A. Bixler, Pedro Romero, Jean Luc Bodmer, Véronique Steiner, Hans Acha-Orbea, Kay Hofmann, Christine Ambrose, Christiane Werner-Favre, Nils Holler, Rudolph H. Zubler, Danila Valmori, Fabienne Mackay, Pornsri Lawton, Jürg Tschopp, Jeffrey L. Browning, Pascal Schneider

Publikováno v: Journal of Experimental Medicine, vol. 189, no. 11, pp. 1747-1756
The Journal of Experimental Medicine

Members of the tumor necrosis factor (TNF) family induce pleiotropic biological responses, including cell growth, differentiation, and even death. Here we describe a novel member of the TNF family, designated BAFF (for B cell activating factor belong

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2848d5f9cbc53b1f7ddd1dff55faa36f
https://serval.unil.ch/resource/serval:BIB_53CE7E893D3E.P001/REF.pdf

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TNF-induced enterocyte apoptosis in mice is mediated by the TNF receptor 1 and does not require p53

Autor: Yves Donati, Constance Barazzone, Jane Guo, Pierre F. Piguet, Christian Vesin

Publikováno v: European Journal of Immunology, Vol. 28, No 11 (1998) pp. 3499-505

Injection of recombinant mouse TNF into mice is known to induce a shrinkage of the duodenal villi, which becomes evident 30-90 min later and is associated with a detachment of enterocytes in the lumen. These cells can be collected by lavage and are a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4720dc6e522a732683d89df54bc4105
https://archive-ouverte.unige.ch/unige:74299

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