An N-glycan on the C2 domain of JAGGED1 is important for Notch activation

Autor: Yao Meng, Sami Sanlidag, Sacha A. Jensen, Sean A. Burnap, Weston B. Struwe, Andreas H. Larsen, Xinyi Feng, Shruti Mittal, Mark S. P. Sansom, Cecilia Sahlgren, Penny A. Handford

Publikováno v: Science Signaling, 15(755):eabo3507. American Association for the Advancement of Science (AAAS)
Meng, Y, Sanlidag, S, Jensen, S A, Burnap, S A, Struwe, W B, Larsen, A H, Feng, X, Mittal, S, Sansom, M S P, Sahlgren, C & Handford, P A 2022, ' An N-glycan on the C2 domain of JAGGED1 is important for Notch activation ', Science Signaling, vol. 15, no. 755, eabo3507 . https://doi.org/10.1126/scisignal.abo3507

The canonical members of the Jagged/Serrate and Delta families of transmembrane ligands have an extracellular, amino-terminal C2 domain that binds to phospholipids and is required for optimal activation of the Notch receptor. Somatic mutations that c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac4c9efe42b092cdfc89289531844635
http://www.scopus.com/inward/record.url?scp=85139651605&partnerID=8YFLogxK

Mechanisms of Notch signaling: a simple logic deployed in time and space

Autor: François Schweisguth, Domingos Henrique

Publikováno v: Development (Cambridge, England)
Development (Cambridge, England), Company of Biologists, 2019, 146 (3), pp.dev172148. ⟨10.1242/dev.172148⟩
Development (Cambridge, England), 2019, 146 (3), pp.dev172148. ⟨10.1242/dev.172148⟩

© 2019. Published by The Company of Biologists. All rights reserved.
Most cells in our body communicate during development and throughout life via Notch receptors and their ligands. Notch receptors relay information from the cell surface to the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e77e08ce392aa0aef7b93d2e5ed67b6d
https://hal-pasteur.archives-ouvertes.fr/pasteur-02348265

Rer1p maintains ciliary length and signaling by regulating γ-secretase activity and Foxj1a levels

Autor: Veerle Baert, H. Joseph Yost, Nathalie Jurisch-Yaksi, Przemko Tylzanowski, Tim Raemaekers, Applonia Josephine Rose, Guy Froyen, Wendy Vermeire, Cammon B. Arrington, Huiqi Lu, Roel Vandepoel, Emre Yaksi, Daphne Verleyen, Wim Annaert, Pieter Baatsen, Sebastian Munck, Thomy de Ravel, Suzie J. Scales

Publikováno v: The Journal of Cell Biology

Rer1p is an ER/cis-Golgi membrane protein that maintains ciliary length and function by reducing γ-secretase complex assembly and activity (thereby balancing Notch signaling) and increasing Foxj1a expression.
Cilia project from the surface of m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0670771d5653c4e13cbdb72f0604ace
http://europepmc.org/articles/PMC3601348

Hedgehog/notch-induced premature gliogenesis represents a new disease mechanism for Hirschsprung disease in mice and humans

Autor: Eric Wai Yin Sat, Brandon J. Wainwright, Hiu-Ching Poon, Stacey S. Cherny, Mai Har Sham, Carmen Ka Man Kwok, Elly Sau-Wai Ngan, CC Hui, Paul K.H. Tam, Benjamin Hon Kei Yip, Maria-Mercè Garcia-Barceló, Vincent C.H. Lui, Pak C. Sham, Kenneth K. Y. Wong, Sin-Ting Lau

Hirschsprung (HSCR) disease is a complex genetic disorder attributed to a failure of the enteric neural crest cells (ENCCs) to form ganglia in the hindgut. Hedgehog and Notch are implicated in mediating proliferation and differentiation of ENCCs. Nev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6297dc95f17a284eed13fac1cba405db
http://hdl.handle.net/10722/137210