Výsledky vyhledávání - "Receptors, LDL/genetics"

Metformin directly suppresses atherosclerosis in normoglycaemic mice via haematopoietic adenosine monophosphate-activated protein kinase

Autor: David Carling, Dorian O. Haskard, Søren K. Moestrup, Justin C. Mason, L. Cave, Joseph J. Boyle, A. Seneviratne, Gareth Hyde

Publikováno v: Seneviratne, A, Cave, L, Hyde, G, Moestrup, S K, Carling, D, Mason, J C, Haskard, D O & Boyle, J J 2021, ' Metformin directly suppresses atherosclerosis in normoglycaemic mice via haematopoietic adenosine monophosphate-activated protein kinase ', Cardiovascular Research, vol. 117, no. 5, pp. 1295-1308 . https://doi.org/10.1093/cvr/cvaa171
Cardiovascular Research

Aims Atherosclerotic vascular disease has an inflammatory pathogenesis. Heme from intraplaque hemorrhage may drive a protective and pro-resolving macrophage M2-like phenotype, Mhem, via AMPK and ATF1. The anti-diabetic drug metformin may also activat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2da685d70a2d1fb7b288da50784ff2a
https://pure.au.dk/portal/da/publications/metformin-directly-suppresses-atherosclerosis-in-normoglycaemic-mice-via-haematopoietic-adenosine-monophosphateactivated-protein-kinase(85ce7ecf-04fc-41c3-957e-86935662d77a).html

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Neutrophil-to-hepatocyte communication via LDLR-dependent miR-223-enriched extracellular vesicle transfer ameliorates nonalcoholic steatohepatitis

Autor: Suxian Zhao, Dechun Feng, Jing Ma, Yaojie Fu, Ruixue Ren, Pal Pacher, Csaba Mátyás, Robim Marcelino Rodrigues, Bin Gao, Wonhyo Seo, Seonghwan Hwang, Eszter Trojnar, George Kunos, Xiaolin Wang, Yong He

Publikováno v: J Clin Invest

Neutrophil infiltration around lipotoxic hepatocytes is a hallmark of nonalcoholic steatohepatitis (NASH); however, how these 2 types of cells communicate remains obscure. We have previously demonstrated that neutrophil-specific microRNA-223 (miR-223

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c867105336d6f2d3b77c1e939fe9f1d0
https://hdl.handle.net/20.500.14017/2c59d630-eeef-4022-90b0-60c31573469b

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Hepatic regulation of VLDL receptor by PPARβ/δ and FGF21 modulates non-alcoholic fatty liver disease

Autor: Zarei, Mohammad, Barroso, Emma, Palomer, Xavier, Dai, Jianli, Rada, Patricia, Quesada-López, Tania, Escolà-Gil, Joan Carles, Cedó, Lídia, Reza Zali, Mohammad, Molaei, Mahsa, Dabiri, Reza, Vázquez, Santiago, Pujol, Eugènia, Valverde, Ángela M., Villarroya, Francesc, Liu, Yong, Wahli, Walter, Vázquez-Carrera, Manuel

Publikováno v: Molecular Metabolism, Vol 8, Iss, Pp 117-131 (2018)
Molecular metabolism
Molecular metabolism, Elsevier, 2018, 8, pp.117-131. ⟨10.1016/j.molmet.2017.12.008⟩
Molecular Metabolism (8), 117-131. (2018)
Molecular metabolism, vol. 8, pp. 117-131
Molecular Metabolism
molecular metabolism
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname
Digital.CSIC. Repositorio Institucional del CSIC
r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
Fundació Sant Joan de Déu

[Objective] The very low-density lipoprotein receptor (VLDLR) plays an important role in the development of hepatic steatosis. In this study, we investigated the role of Peroxisome Proliferator-Activated Receptor (PPAR)b/d and fibroblast growth facto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f5ad2bfbce1b58196f75d620a63de476
http://www.sciencedirect.com/science/article/pii/S2212877817306622

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Deubiquitylase Inhibition Reveals Liver X Receptor-independent Transcriptional Regulation of the E3 Ubiquitin Ligase IDOL and Lipoprotein Uptake

Autor: Peter L. Hordijk, Igor Kovacevic, Saskia Scheij, Emma C. L. Cook, Noam Zelcer, Jessica K. Nelson, Anke Loregger, Huib Ovaa, Marten A. Hoeksema

Publikováno v: Journal of biological chemistry, 291(9), 4813-4825. American Society for Biochemistry and Molecular Biology Inc.
Journal of Biological Chemistry, 291(9), 4813-4825. American Society for Biochemistry and Molecular Biology Inc.
Nelson, J K, Cook, E C L, Loregger, A, Hoeksema, M A, Scheij, S, Kovacevic, I, Hordijk, P L, Ovaa, H & Zelcer, N 2016, ' Deubiquitylase Inhibition Reveals Liver X Receptor-independent Transcriptional Regulation of the E3 Ubiquitin Ligase IDOL and Lipoprotein Uptake ', Journal of Biological Chemistry, vol. 291, no. 9, pp. 4813-4825 . https://doi.org/10.1074/jbc.M115.698688

Cholesterol metabolism is subject to complex transcriptional and nontranscriptional regulation. Herein, the role of ubiquitylation is emerging as an important post-translational modification that regulates cholesterol synthesis and uptake. Similar to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cedf0913ddcfb2603c43cc631340d66d
https://doi.org/10.1074/jbc.m115.698688

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Association of Triglyceride-Lowering LPL Variants and LDL-C–Lowering LDLR Variants With Risk of Coronary Heart Disease

Autor: Adam S. Butterworth, Deepak L. Bhatt, Alberico L. Catapano, Angela M. Wood, Chris J. Packard, Ulrich Laufs, Marc S. Sabatine, Stephen J. Nicholls, John J.P. Kastelein, Clare Oliver-Williams, John Danesh, Kausik K. Ray, Brian A. Ference, Henry N. Ginsberg, M. John Chapman, Emanuele Di Angelantonio

Publikováno v: JAMA, 321(4), 364-373. American Medical Association
Ference, B A, Kastelein, J J P, Ray, K K, Ginsberg, H N, Chapman, M J, Packard, C J, Laufs, U, Oliver-Williams, C, Wood, A M, Butterworth, A S, Di Angelantonio, E, Danesh, J, Nicholls, S J, Bhatt, D L, Sabatine, M S & Catapano, A L 2019, ' Association of Triglyceride-Lowering LPL Variants and LDL-C-Lowering LDLR Variants with Risk of Coronary Heart Disease ', JAMA-Journal of the American Medical Association, vol. 321, no. 4, pp. 364-373 . https://doi.org/10.1001/jama.2018.20045

Importance: Triglycerides and cholesterol are both carried in plasma by apolipoprotein B (ApoB)-containing lipoprotein particles. It is unknown whether lowering plasma triglyceride levels reduces the risk of cardiovascular events to the same extent a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c250d644c00330364b70d0c9bb0eb94
https://europepmc.org/articles/PMC6439767/

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Biochemical and cognitive effects of docosahexaenoic acid differ in a developmental and SorLA dependent manner

Autor: Mette Richner, Anne Højland, Jens R. Nyengaard, Anders Nykjaer, Jens Lykkesfeldt, Amanda Eskelund, Simon Molgaard, Simon Glerup, Ruthe Storgaard Dieu, Morten Nielsen

Publikováno v: Højland, A, Richner, M, Mølgaard, S, Dieu, R S, Eskelund, A, Nykjær, A, Nyengaard, J R, Lykkesfeldt, J, Glerup, S & Nielsen, M S 2018, ' Biochemical and cognitive effects of docosahexaenoic acid differ in a developmental and SorLA dependent manner ', Behavioural Brain Research, vol. 348, pp. 90-100 . https://doi.org/10.1016/j.bbr.2018.04.017

Beneficial effects of omega-3 fatty acid intake on cognition are under debate as some studies show beneficial effects while others show no effects of omega-3 supplementation. These inconsistencies may be a result of inter-individual response variatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::876f747987cca12e976f1e38c029ddfe
https://pure.au.dk/portal/da/publications/biochemical-and-cognitive-effects-of-docosahexaenoic-acid-differ-in-a-developmental-and-sorla-dependent-manner(ec0c4896-c30a-41e3-b8f6-ef2c7de53fe5).html

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The PDK1 Inhibitor Dichloroacetate Controls Cholesterol Homeostasis Through the ERK5/MEF2 Pathway

Publikováno v: Scientific Reports
Recercat. Dipósit de la Recerca de Catalunya
instname
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Scientific Reports, 2017, 7 (1), ⟨10.1038/s41598-017-10339-5⟩
Scientific Reports, Nature Publishing Group, 2017, 7 (1), ⟨10.1038/s41598-017-10339-5⟩
Scientific reports, vol. 7, no. 1, pp. 10654
Repositorio Abierto de la UdL
Universitad de Lleida

Controlling cholesterol levels is a major challenge in human health, since hypercholesterolemia can lead to serious cardiovascular disease. Drugs that target carbohydrate metabolism can also modify lipid metabolism and hence cholesterol plasma levels

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::bbeed3fffbef84478d27734b17774dee
http://europepmc.org/articles/PMC5587676

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Deficiency of ATP-binding cassette transporter B6 in megakaryocyte progenitors accelerates atherosclerosis in mice

Autor: Sandra Abramowicz, Andrew J. Murphy, Nan Wang, Laurent Yvan-Charvet, Nora Bijl, Marit Westerterp, Carrie L. Welch, John D. Schuetz, Vincent Sarrazy

Publikováno v: Arteriosclerosis, thrombosis, and vascular biology, 34(4), 751-758. LIPPINCOTT WILLIAMS & WILKINS

Objective— The ATP-binding cassette (ABC) transporter B6 (ABCB6) is highly expressed in megakaryocyte progenitors, but its role in platelet production and disease has not been elucidated. Approach and Results— Among various ABC transporters, ABCB

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da52daaa96784b1527926dbcecba4647
https://research.rug.nl/en/publications/6f8ad1cb-2110-45b1-9b7c-7ab75b9bc8ad

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CCR6 selectively promotes monocyte mediated inflammation and atherogenesis in mice

Autor: Helga D. Manthey, Martin Busch, Christian Weber, Alma Zernecke, Jaroslav Pelisek, Ela Karshovska, Miriam Koch, Stefanie Barnsteiner, Rory R. Koenen, Hans-Henning Eckstein, Clément Cochain, Sweena M. Chaudhari

Publikováno v: Thrombosis and Haemostasis, 110(6), 1267-77. Georg Thieme Verlag

SummaryThe chemokine receptor CCR6 is expressed by various cell subsets implicated in atherogenesis, such as monocytes, Th17 and regulatory T cells. In order to further define the role of CCR6 in atherosclerosis, CCR6-deficient (Ccr6 -/-) mice were c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a087bd2b0aecfab3cd059fae174b81a
https://doi.org/10.1160/th13-01-0017

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Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma

Autor: Daniel Robyr, C. Victor Jongeneel, Keith Harshman, Armand Valsesia, Sergey Nikolaev, Olesya Bukach, Olivier Michielin, Katja Muehlethaler, Stylianos E. Antonarakis, Thanos D. Halazonetis, Corinne Gehrig, Ioannis Xenarios, Michel Guipponi, Jacques S. Beckmann, Daniel E. Speiser, Donata Rimoldi, Vincent Zoete, Christian Iseli, Brian Stevenson

Publikováno v: Nature genetics
Nature Genetics, Vol. 44, No 2 (2012) pp. 133-9

We performed exome sequencing to detect somatic mutations in protein-coding regions in seven melanoma cell lines and donor-matched germline cells. All melanoma samples had high numbers of somatic mutations, which showed the hallmark of UV-induced DNA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2575587190a5d58a2097099182f25f9
https://doi.org/10.1038/ng.1026

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