Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Receptors, Cell Surface/agonists"'
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(16)
While historically ‘in vitro’ binding data were obtained by analyzing equilibrium experiments, kinetic data are increasingly appreciated to provide information on the time a particular compound remains bound to its target. This information is of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b45a990e5e4ca808a8344ff6e88b0686
https://pubmed.ncbi.nlm.nih.gov/28666735
https://pubmed.ncbi.nlm.nih.gov/28666735
Autor:
Graeme Milligan, Sunil K. Pandey, Brian D. Hudson, Amanda E. Mackenzie, Irina G. Tikhonova, Elisabeth Christiansen, Hannah Murdoch, Maria E Due-Hansen, Trond Ulven, Anna Mette Hansen, Richard J. Ward, Rudi Marquez
Publikováno v:
The Journal of Biological Chemistry
Hudson, B D, Due-Hansen, M E, Christiansen, E, Hansen, A M, Mackenzie, A E, Murdoch, H, Pandey, S K, Ward, R J, Marquez, R, Tikhonova, I G, Ulven, T & Milligan, G 2013, ' Defining the molecular basis for the first potent and selective orthosteric agonists of the FFA2 free fatty acid receptor ', Journal of Biological Chemistry, vol. 288, no. 24, pp. 17296-17312 . https://doi.org/10.1074/jbc.M113.455337
Hudson, B D, Due-Hansen, M E, Christiansen, E, Hansen, A, Mackenzie, A E, Murdoch, H, Pandey, S K, Ward, R J, Marquez, R, Tikhonova, I G, Ulven, T & Milligan, G 2013, ' Defining the molecular basis for the first potent and selective orthosteric agonists of the FFA2 free fatty acid receptor ', Journal of Biological Chemistry, vol. 288, pp. 17296-17312 . https://doi.org/10.1074/jbc.M113.455337
Hudson, B D, Due-Hansen, M E, Christiansen, E, Hansen, A M, Mackenzie, A E, Murdoch, H, Pandey, S K, Ward, R J, Marquez, R, Tikhonova, I G, Ulven, T & Milligan, G 2013, ' Defining the molecular basis for the first potent and selective orthosteric agonists of the FFA2 free fatty acid receptor ', Journal of Biological Chemistry, vol. 288, no. 24, pp. 17296-17312 . https://doi.org/10.1074/jbc.M113.455337
Hudson, B D, Due-Hansen, M E, Christiansen, E, Hansen, A, Mackenzie, A E, Murdoch, H, Pandey, S K, Ward, R J, Marquez, R, Tikhonova, I G, Ulven, T & Milligan, G 2013, ' Defining the molecular basis for the first potent and selective orthosteric agonists of the FFA2 free fatty acid receptor ', Journal of Biological Chemistry, vol. 288, pp. 17296-17312 . https://doi.org/10.1074/jbc.M113.455337
Background: Understanding the function of FFA2 has been slowed by a lack of selective orthosteric ligands. Results: Residues within FFA2 that dictate the recognition and function of potent and selective orthosteric agonists are described. Conclusion:
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc95593b410c8497ec6ceed8e3f6d972
https://pubmed.ncbi.nlm.nih.gov/23589301
https://pubmed.ncbi.nlm.nih.gov/23589301
Publikováno v:
Hudson, B D, Ulven, T & Milligan, G 2013, ' The therapeutic potential of allosteric ligands for free fatty acid sensitive GPCRs ', Current Topics in Medicinal Chemistry, vol. 13, no. 1, pp. 14-25 . https://doi.org/10.2174/1568026611313010004
University of Copenhagen
University of Copenhagen
G protein coupled receptors (GPCRs) are the most historically successful therapeutic targets. Despite this success there are many important aspects of GPCR pharmacology and function that have yet to be exploited to their full therapeutic potential. O
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc1459f594a3e8bae65becb45379fce1
https://portal.findresearcher.sdu.dk/da/publications/56decd70-a0b8-4add-8e59-128c617aae85
https://portal.findresearcher.sdu.dk/da/publications/56decd70-a0b8-4add-8e59-128c617aae85
