Zobrazeno 1 - 10
of 5 038
pro vyhledávání: '"Receptor tyrosine kinases"'
Publikováno v:
Current Issues in Molecular Biology, Vol 46, Iss 10, Pp 11220-11235 (2024)
Angiogenesis plays a pivotal role in the growth, survival, and metastasis of solid tumors, with Vascular Endothelial Growth Factor Receptor-2 (VEGFR-2) being overexpressed in many human solid tumors, making it an appealing target for anti-cancer ther
Externí odkaz:
https://doaj.org/article/a4500ff115c3498f9d4f081edfdce668
Autor:
Xuesai Zhu, Shenjie Sun, Yizhi Yao, Fan Jiang, Fenghua Yang, Haibo Zhao, Zichao Xue, Shiyou Dai, Tengbo Yu, Xiao Xiao
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Anterior cruciate ligament (ACL) injury is a common orthopedic disease with a high incidence, long recovery time, and often requiring surgical treatment. However, the susceptibility factors for ACL injury are currently unclear, and there is
Externí odkaz:
https://doaj.org/article/5b117509e7174ab296fa971128c93e95
Autor:
Luke J. Joyce, Andrew J. Lindsay
Publikováno v:
Biochemistry and Biophysics Reports, Vol 38, Iss , Pp 101700- (2024)
Glioblastoma (GBM) is the most common and aggressive brain cancer in adults. The standard treatment is brutal and has changed little in 20 years, and more than 85% of patients will die within two years of their diagnosis. There is thus an urgent need
Externí odkaz:
https://doaj.org/article/5a3b2bb5546143278590df156f627e39
Publikováno v:
eLife, Vol 12 (2024)
Phosphoinositide 3-kinase (PI3K) beta (PI3Kβ) is functionally unique in the ability to integrate signals derived from receptor tyrosine kinases (RTKs), G-protein coupled receptors, and Rho-family GTPases. The mechanism by which PI3Kβ prioritizes in
Externí odkaz:
https://doaj.org/article/6de0b5fba85a44e4a804a1cf78fa3cea
Autor:
E. A. Gantsova, O. V. Serova, D. Eladari, D. M. Bobrovskiy, A. G. Petrenko, A. V. Elchaninov, I. E. Deyev
Publikováno v:
Current Issues in Molecular Biology, Vol 45, Iss 12, Pp 9709-9722 (2023)
The maintenance of plasma pH is critical for life in all organisms. The kidney plays a critical role in acid–base regulation in vertebrates by controlling the plasma concentration of bicarbonate. The receptor tyrosine kinase IRR (insulin receptor-r
Externí odkaz:
https://doaj.org/article/7ecc54c59952492283d2dac0c66b2d20
Publikováno v:
Journal of Inflammation Research, Vol Volume 16, Pp 4845-4855 (2023)
Yandan Zhou,1 Zhili Feng,2,3 Jie Wen,2,3 Chi Yang,2,3 Qiancheng Jing2,3 1Changsha Aier Eye Hospital, Aier Eye Hospital Group, Changsha, Hunan, People’s Republic of China; 2Department of Otolaryngology Head and Neck Surgery, the Affiliated Changsha
Externí odkaz:
https://doaj.org/article/716055437a4049b79668ec5b2b8285c5
Publikováno v:
eLife, Vol 12 (2024)
Human Epidermal growth factor Receptor 4 (HER4 or ERBB4) carries out essential functions in the development and maintenance of the cardiovascular and nervous systems. HER4 activation is regulated by a diverse group of extracellular ligands including
Externí odkaz:
https://doaj.org/article/bc19c740093f48b8a2cb5fc7b76488b3
Autor:
Elena Muraro, Barbara Montico, Benedict Lum, Francesca Colizzi, Giorgio Giurato, Annamaria Salvati, Roberto Guerrieri, Aurora Rizzo, Elisa Comaro, Vincenzo Canzonieri, Andrea Anichini, Michele Del Vecchio, Roberta Mortarini, Massimo Milione, Alessandro Weisz, Maria Antonietta Pizzichetta, Fiona Simpson, Riccardo Dolcetti, Elisabetta Fratta, Luca Sigalotti
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionAbout 50% of cutaneous melanoma (CM) patients present activating BRAF mutations that can be effectively targeted by BRAF inhibitors (BRAFi). However, 20% of CM patients exhibit intrinsic drug resistance to BRAFi, while most of the others
Externí odkaz:
https://doaj.org/article/9efcdcc70a744ed59d4d5235c051bf86
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/edfafdc3548e41ca9fcd55a183a80298
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
Receptor tyrosine kinases (RTKs) play a crucial role in cellular signaling and oncogenic progression. Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKIs) have become the standard treatment for advanced non-small cell lung cancer (
Externí odkaz:
https://doaj.org/article/1f5281f73d9540c9aae7ef6f8d8ccdc0