Zobrazeno 1 - 10
of 480
pro vyhledávání: '"Receptor selectivity"'
Akademický článek
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Autor:
Kayleigh Walker, Roberta Baravalle, Rachel Holyfield, Jacqueline Kalms, Helena Wright, Chitra Seewooruthun, Frederick W. Muskett, Anthony Scott-Tucker, Andy Merritt, Alistair Henry, Alastair D. G. Lawson, Gareth Hall, Christine Prosser, Mark D. Carr
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Interleukin-13 (IL-13) is a cytokine involved in T-cell immune responses and is a well validated therapeutic target for the treatment of asthma, along with other allergic and inflammatory diseases. IL-13 signals through a ternary signalling complex f
Externí odkaz:
https://doaj.org/article/ed60b6efb669458b96fb34943581aadf
Publikováno v:
Clinical Parkinsonism & Related Disorders, Vol 9, Iss , Pp 100212- (2023)
Dopamine agonists (DAs) have demonstrated efficacy for the treatment of Parkinson’s disease (PD) but are limited by adverse effects (AEs). DAs can vary considerably in their receptor subtype selectivity and affinity, chemical composition, receptor
Externí odkaz:
https://doaj.org/article/6bb39d7d90864ed6bf7da28ea879c603
Autor:
Claudia Mugnaini, Magdalena Kostrzewa, Marta Casini, Poulami Kumar, Valeria Catallo, Marco Allarà, Laura Guastaferro, Antonella Brizzi, Marco Paolino, Andrea Tafi, Christelos Kapatais, Gianluca Giorgi, Federica Vacondio, Marco Mor, Federico Corelli, Alessia Ligresti
Publikováno v:
Molecules, Vol 28, Iss 13, p 4958 (2023)
Selective ligands of the CB2 receptor are receiving considerable attention due to their potential as therapeutic agents for a variety of diseases. Recently, 7-hydroxy-5-oxopyrazolo[4,3-b]pyridine-6-carboxamide derivatives were shown to act at the CB2
Externí odkaz:
https://doaj.org/article/1a82bb1f8bab4fb8bc8f13d08c4c3492
Autor:
Ligresti, Claudia Mugnaini, Magdalena Kostrzewa, Marta Casini, Poulami Kumar, Valeria Catallo, Marco Allarà, Laura Guastaferro, Antonella Brizzi, Marco Paolino, Andrea Tafi, Christelos Kapatais, Gianluca Giorgi, Federica Vacondio, Marco Mor, Federico Corelli, Alessia
Publikováno v:
Molecules; Volume 28; Issue 13; Pages: 4958
Selective ligands of the CB2 receptor are receiving considerable attention due to their potential as therapeutic agents for a variety of diseases. Recently, 7-hydroxy-5-oxopyrazolo[4,3-b]pyridine-6-carboxamide derivatives were shown to act at the CB2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::c1e38441112e878ff826ebc81c27a5ec
Autor:
Lena Tveriakhina, Karin Schuster-Gossler, Sanchez M Jarrett, Marie B Andrawes, Meike Rohrbach, Stephen C Blacklow, Achim Gossler
Publikováno v:
eLife, Vol 7 (2018)
DLL1 and DLL4 are Notch ligands with high structural similarity but context-dependent functional differences. Here, we analyze their functional divergence using cellular co-culture assays, biochemical studies, and in vivo experiments. DLL1 and DLL4 a
Externí odkaz:
https://doaj.org/article/3e44a1b2e4f44a3eb3307bd5a10ef345
Akademický článek
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Autor:
Richard Lim, Danny J. Eckert, Luigi Taranto-Montemurro, Jayne C. Carberry, Scott A. Sands, A Aishah, Andrew Wellman
Publikováno v:
J Appl Physiol (1985)
The combination of the noradrenergic agent atomoxetine plus the antimuscarinic oxybutynin has recently been shown to improve upper airway physiology and reduce obstructive sleep apnea (OSA) severity. However, the effects of different antimuscarinics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5be46cd4942cea83ef0c7f8c91c9eb3
https://doi.org/10.1152/japplphysiol.01074.2020
https://doi.org/10.1152/japplphysiol.01074.2020
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
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Publikováno v:
New Journal of Chemistry. 45:12688-12699
Cannabinoid (CB) receptors play a vital role in many pathophysiological processes. Selective CB2 activation may lead to the immuno-modulatory effects of cannabinoids being experienced without the psychoactive effects of CB1 activation; however, despi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8399e56646e807a21ea5307c3ed5ee30
https://doi.org/10.1039/d1nj02296b
https://doi.org/10.1039/d1nj02296b