AXL/GAS6 signaling governs differentiation of tumor-associated macrophages in breast cancer.

Autor: Purohit S; Immunology Laboratory, Department of Zoology, University of Calcutta, 35, Ballygunge Circular Road, Kolkata, 700019, West Bengal, India; Department of Zoology, Gurudas College, 1/1, Suren Sarkar Road, Phool Bagan, Kolkata, 700054, West Bengal, India., Mandal G; Immunology Laboratory, Department of Zoology, University of Calcutta, 35, Ballygunge Circular Road, Kolkata, 700019, West Bengal, India; Division of Cancer Biology, DBT-Institute of Life Sciences, Bhubaneswar, 751023, India., Biswas S; Immunology Laboratory, Department of Zoology, University of Calcutta, 35, Ballygunge Circular Road, Kolkata, 700019, West Bengal, India; Tumor Immunology and Immunotherapy, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar, Navi Mumbai, 410210, India; Homi Bhabha National Institute, Anushaktinagar, Mumbai, 400 094, Maharashtra, India., Dalui S; Immunology Laboratory, Department of Zoology, University of Calcutta, 35, Ballygunge Circular Road, Kolkata, 700019, West Bengal, India., Gupta A; Department of Surgical Oncology, Saroj Gupta Cancer Centre and Research Institute, Mahatma Gandhi Road, Kolkata, 700063, West Bengal, India., Chowdhury SR; Immunology Laboratory, Department of Zoology, University of Calcutta, 35, Ballygunge Circular Road, Kolkata, 700019, West Bengal, India; Translational Immunology Laboratory, Department of Life Science and Biotechnology, Jadavpur University, Kolkata, 700032, West Bengal, India., Bhattacharyya A; Immunology Laboratory, Department of Zoology, University of Calcutta, 35, Ballygunge Circular Road, Kolkata, 700019, West Bengal, India. Electronic address: arindam19@yahoo.com.

Publikováno v: Experimental cell research [Exp Cell Res] 2025 Jan 01; Vol. 444 (1), pp. 114324. Date of Electronic Publication: 2024 Nov 06.

AXL-TBK1 driven AKT3 activation promotes metastasis.

Autor: Arner EN; Cancer Biology Graduate Program, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.; Department of Surgery and the Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Alzhanova D; Department of Surgery and the Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Westcott JM; Department of Surgery and the Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Hinz S; Department of Biomedicine and Centre for Cancer Biomarkers, University of Bergen, Bergen, Norway.; BerGenBio ASA, Bergen, Norway., Tiron CE; Department of Biomedicine and Centre for Cancer Biomarkers, University of Bergen, Bergen, Norway.; Regional Institute of Oncology, Iasi, Romania., Blø M; BerGenBio ASA, Bergen, Norway., Mai A; BerGenBio ASA, Bergen, Norway., Virtakoivu R; Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520 Turku, Finland.; Department of Life Technologies, University of Turku, 20520 Turku, Finland.; InFLAMES Research Flagship Center, University of Turku, 20520 Turku, Finland., Phinney N; Cancer Biology Graduate Program, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.; Department of Surgery and the Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Nord S; Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway., Aguilera KY; BerGenBio ASA, Bergen, Norway., Rizvi A; Department of Surgery and the Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Toombs JE; Department of Surgery and the Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Reese TC; Cancer Biology Graduate Program, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Fey V; Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520 Turku, Finland.; Department of Life Technologies, University of Turku, 20520 Turku, Finland.; InFLAMES Research Flagship Center, University of Turku, 20520 Turku, Finland., Micklem D; BerGenBio ASA, Bergen, Norway., Gausdal G; BerGenBio ASA, Bergen, Norway., Ivaska J; Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520 Turku, Finland.; Department of Life Technologies, University of Turku, 20520 Turku, Finland.; InFLAMES Research Flagship Center, University of Turku, 20520 Turku, Finland., Lorens JB; Department of Biomedicine and Centre for Cancer Biomarkers, University of Bergen, Bergen, Norway., Brekken RA; Cancer Biology Graduate Program, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.; Department of Surgery and the Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.; Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Publikováno v: Science signaling [Sci Signal] 2024 Dec 17; Vol. 17 (867), pp. eado6057. Date of Electronic Publication: 2024 Dec 17.

Gas6/Axl signaling promotes hematoma resolution and motivates protective microglial responses after intracerebral hemorrhage in mice.

Autor: Ye XH; Department of Rehabilitation, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China., Xu ZM; Department of Neurology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China., Shen D; Department of Neurology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China; Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China., Jin YJ; Department of Neurology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China., Li JW; Department of Neurology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China., Xu XH; Department of Neurology, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu 322000, China., Tong LS; Department of Neurology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China. Electronic address: 2310040@zju.edu.cn., Gao F; Department of Neurology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China. Electronic address: 2202012@zju.edu.cn.

Publikováno v: Experimental neurology [Exp Neurol] 2024 Dec; Vol. 382, pp. 114964. Date of Electronic Publication: 2024 Sep 15.

RON receptor tyrosine kinase as a critical determinant in promoting tumorigenic behaviors of bladder cancer cells through regulating MMP12 and HIF-2α pathways.

Autor: Wang KJ; Translational Research Laboratory for Urological Diseases, the First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, P. R. China.; Comprehensive Genitourinary Cancer Center, the First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, P. R. China., Ye SZ; Translational Research Laboratory for Urological Diseases, the First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, P. R. China.; Comprehensive Genitourinary Cancer Center, the First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, P. R. China., Jia XL; Department of Urology, the First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, P. R. China., Wang KY; Department of Urology, the Affiliated People's Hospital of Ningbo University, Ningbo, Zhejiang, P.R. China., Meng XY; Translational Research Laboratory for Urological Diseases, the First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, P. R. China.; Comprehensive Genitourinary Cancer Center, the First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, P. R. China., Fei X; Health Science Center, Ningbo University, Ningbo, Zhejiang, P.R. China., Ye SJ; Health Science Center, Ningbo University, Ningbo, Zhejiang, P.R. China., Ma Q; Comprehensive Genitourinary Cancer Center, the First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, P. R. China. fyymaqi@nbu.edu.cn.; Yi-huan Genitourinary Cancer Group, Ningbo, Zhejiang, P.R. China. fyymaqi@nbu.edu.cn.

Publikováno v: Cell death & disease [Cell Death Dis] 2024 Nov 19; Vol. 15 (11), pp. 844. Date of Electronic Publication: 2024 Nov 19.

PFKP silencing suppresses tumor growth via the AXL-MET axis.

Autor: Zhao H; Department of Oncology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.; Department of Human Cell Biology and Genetics, Joint Laboratory of Guangdong-Hong Kong Universities for Vascular Homeostasis and Diseases, School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong 518055, China., Sun Y; Department of Human Cell Biology and Genetics, Joint Laboratory of Guangdong-Hong Kong Universities for Vascular Homeostasis and Diseases, School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong 518055, China.; Mechanobiology Institute, National University of Singapore, Singapore., Feng H; Cancer Center, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, Shanxi, China., Cai J; Department of Oncology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China., Liu Y; Department of Human Cell Biology and Genetics, Joint Laboratory of Guangdong-Hong Kong Universities for Vascular Homeostasis and Diseases, School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong 518055, China., Li Y; Department of Human Cell Biology and Genetics, Joint Laboratory of Guangdong-Hong Kong Universities for Vascular Homeostasis and Diseases, School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong 518055, China., Chen S; Department of Human Cell Biology and Genetics, Joint Laboratory of Guangdong-Hong Kong Universities for Vascular Homeostasis and Diseases, School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong 518055, China., Zhou Z; Department of Human Cell Biology and Genetics, Joint Laboratory of Guangdong-Hong Kong Universities for Vascular Homeostasis and Diseases, School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong 518055, China., Du Y; Department of Human Cell Biology and Genetics, Joint Laboratory of Guangdong-Hong Kong Universities for Vascular Homeostasis and Diseases, School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong 518055, China., Zeng X; Department of Human Cell Biology and Genetics, Joint Laboratory of Guangdong-Hong Kong Universities for Vascular Homeostasis and Diseases, School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong 518055, China.; National Key Laboratory for Tropical Crop Breeding, Shenzhen Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, Guangdong 518120, China., Ren H; School of Medicine, Southern University of Science and Technology, Shenzhen, China., Su W; Department of Oncology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China., Mei Q; Cancer Center, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.; Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei, Wuhan, China., Chen G; Department of Human Cell Biology and Genetics, Joint Laboratory of Guangdong-Hong Kong Universities for Vascular Homeostasis and Diseases, School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong 518055, China.; The First Affiliated Hospital of Southern University of Science and Technology, Shenzhen, China.

Publikováno v: International journal of biological sciences [Int J Biol Sci] 2024 Nov 11; Vol. 20 (15), pp. 6056-6072. Date of Electronic Publication: 2024 Nov 11 (Print Publication: 2024).