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The Trifluoromethyl Group as a Bioisosteric Replacement of the Aliphatic Nitro Group in CB1 Receptor Positive Allosteric Modulators

Autor: Matteo Zanda, Sergio Dall'Angelo, Giulia Donvito, Aron H. Lichtman, Chiara Zanato, Iain R. Greig, Sophie E. Juola, Mohammed A. Mustafa, Ruth A. Ross, Gemma L. Baillie, Chih-Chung Tseng, William T. A. Harrison, Chiara Massarenti

Publikováno v: J Med Chem
Journal of medicinal chemistry 62 (2019): 5049–5062. doi:10.1021/acs.jmedchem.9b00252
info:cnr-pdr/source/autori:Tseng C.-C.; Baillie G.; Donvito G.; Mustafa M.A.; Juola S.E.; Zanato C.; Massarenti C.; Dall'Angelo S.; Harrison W.T.A.; Lichtman A.H.; Ross R.A.; Zanda M.; Greig I.R./titolo:The Trifluoromethyl Group as a Bioisosteric Replacement of the Aliphatic Nitro Group in CB1 Receptor Positive Allosteric Modulators/doi:10.1021%2Facs.jmedchem.9b00252/rivista:Journal of medicinal chemistry/anno:2019/pagina_da:5049/pagina_a:5062/intervallo_pagine:5049–5062/volume:62

The first generation of CB(1) positive allosteric modulators (e.g., ZCZ011) featured a 3-nitroalkyl-2-phenyl-indole structure. Although a small number of drugs include the nitro group, it is generally not regarded as being “drug-like”, and this i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::429df73de2b0a760a53541b1b6887b26
https://doi.org/10.1021/acs.jmedchem.9b00252

Charakterisierung von Parkinson-assoziierten DJ-1-Mutanten und Einfluss von alpha-synuklein auf Gliazellen

Autor: Rannikko, Emmy Helena

Mutations in the DJ-1 gene are rare causes of early onset autosomal recessive Parkinson’s disease. DJ-1 is a ubiquitously expressed, cytoprotective protein. The most severe Parkinson’s disease associated mutations of DJ-1 lead to absence of the p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______707::b05ebc048e43acfe6640d846a1efe9da
https://hdl.handle.net/10900/50085

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Vitamin D Receptor Gene Polymorphisms, Metabolic Syndrome, and Type 2 Diabetes in Iranian Subjects: No Association with Observed SNPs.

Autor: Shab-Bidar S; 1Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran., Neyestani TR; 2Laboratory of Nutrition Research, National Nutrition and Food Technology Research Institute and Faculty of Nutrition and Food Technology Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Djazayery A; 1Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.

Publikováno v: International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition [Int J Vitam Nutr Res] 2016 Feb; Vol. 86 (1-2), pp. 71-80. Date of Electronic Publication: 2017 Feb 10.