Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Recep Adiyaman"'
Autor:
Recep Adiyaman, Liam James McGuffin
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 9, p 2301 (2019)
The refinement of predicted 3D protein models is crucial in bringing them closer towards experimental accuracy for further computational studies. Refinement approaches can be divided into two main stages: The sampling and scoring stages. Sampling str
Externí odkaz:
https://doaj.org/article/6c5a83fadf2144a58d788732c21e6603
Autor:
Liam J McGuffin, Nicholas S Edmunds, Ahmet G Genc, Shuaa M A Alharbi, Bajuna R Salehe, Recep Adiyaman
Publikováno v:
Nucleic Acids Research.
The IntFOLD server based at the University of Reading has been a leading method over the past decade in providing free access to accurate prediction of protein structures and functions. In a post-AlphaFold2 world, accurate models of tertiary structur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cfa9272a3defc2ae7b343865638eef7f
https://doi.org/10.1093/nar/gkad297
https://doi.org/10.1093/nar/gkad297
In CASP15 there was a greater emphasis on multimeric modelling than in previous experiments, with assembly structures nearly doubling in number (41 up from 22) since the previous round. CASP15 also included a new estimation of model accuracy (EMA) ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::130143278c8e259a0581a10112a05e01
https://doi.org/10.22541/au.168053625.53345509/v1
https://doi.org/10.22541/au.168053625.53345509/v1
Autor:
Recep Adiyaman, Liam J. McGuffin
Publikováno v:
Methods in Molecular Biology ISBN: 9781071629734
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00dfc111a5c6ae6469a1c09024146ed2
https://doi.org/10.1007/978-1-0716-2974-1_7
https://doi.org/10.1007/978-1-0716-2974-1_7
MotivationThe accuracy gap between predicted and experimental structures has been significantly reduced following the development of AlphaFold2. However, for further studies, such as drug discovery and protein design, AlphaFold2 structures need to be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e0b7637e1eb8d8e551c1e493d9a30f14
https://doi.org/10.1101/2022.12.06.519289
https://doi.org/10.1101/2022.12.06.519289
Publikováno v:
Nucleic Acids Research
Methods for estimating the quality of 3D models of proteins are vital tools for driving the acceptance and utility of predicted tertiary structures by the wider bioscience community. Here we describe the significant major updates to ModFOLD, which ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d97552dc20624cb727de29e238b2715
http://europepmc.org/articles/PMC8218196
http://europepmc.org/articles/PMC8218196
Autor:
Recep Adiyaman, Liam J. McGuffin
Publikováno v:
Nucleic Acids Research
ReFOLD3 is unique in its application of gradual restraints, calculated from local model quality estimates and contact predictions, which are used to guide the refinement of theoretical 3D protein models towards the native structures. ReFOLD3 achieves
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c63a808d9bbb6e08fa5a3192399b8c74
http://europepmc.org/articles/PMC8218204
http://europepmc.org/articles/PMC8218204
Autor:
Neline Kriek, Recep Adiyaman, Sarah K. AlOuda, Sakthivel Vaiyapuri, Gagan D. Flora, Mohammad AboHassan, Chris I. Jones, Amro Elgheznawy, Amanda J. Unsworth, Alexander R. Stainer, Alexander P. Bye, Jonathan M. Gibbins, Ali H. A. Maghrabi, Lisa-Marie Holbrook, Tanya Sage, Liam J. McGuffin, Khaled A. Sahli, Marilena Crescente, Parvathy Sasikumar
Publikováno v:
Blood
Connexins oligomerise to form hexameric hemichannels in the plasma membrane that can further dock together on adjacent cells to form gap junctions and facilitate intercellular trafficking of molecules. In this study, we report the expression and func
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c70797cc5e328d572812b333558d090
https://pubmed.ncbi.nlm.nih.gov/32822477
https://pubmed.ncbi.nlm.nih.gov/32822477
Autor:
John O. Nealon, Recep Adiyaman, Ahmad N. Shuid, Limcy Seby Philomina, Ali H. A. Maghrabi, Danielle A Brackenridge, Liam J. McGuffin
Publikováno v:
Nucleic Acids Research
The IntFOLD server provides a unified resource for the automated prediction of: protein tertiary structures with built-in estimates of model accuracy (EMA), protein structural domain boundaries, natively unstructured or disordered regions in proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c87ba9bbfff4693631f838694ac93c0e
https://centaur.reading.ac.uk/83525/1/PUBLISHED_VERSION_gkz322.pdf
https://centaur.reading.ac.uk/83525/1/PUBLISHED_VERSION_gkz322.pdf
Autor:
Liam J. McGuffin, Recep Adiyaman
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 20, Iss 9, p 2301 (2019)
International Journal of Molecular Sciences, Vol 20, Iss 9, p 2301 (2019)
The refinement of predicted 3D protein models is crucial in bringing them closer towards experimental accuracy for further computational studies. Refinement approaches can be divided into two main stages: The sampling and scoring stages. Sampling str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa6c7c794d657023a14e4e03b1ab854c
http://europepmc.org/articles/PMC6539982
http://europepmc.org/articles/PMC6539982