Zobrazeno 1 - 10
of 401
pro vyhledávání: '"Recent Thymic Emigrant"'
Autor:
Sarah J. Potter, Li Zhang, Michael Kotliar, Yuehong Wu, Caitlin Schafer, Kurtis Stefan, Leandros Boukas, Dima Qu’d, Olaf Bodamer, Brittany N. Simpson, Artem Barski, Andrew W. Lindsley, Hans T. Bjornsson
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Individuals with Kabuki syndrome present with immunodeficiency; however, how pathogenic variants in the gene encoding the histone-modifying enzyme lysine methyltransferase 2D (KMT2D) lead to immune alterations remain poorly understood. Following up o
Externí odkaz:
https://doaj.org/article/cf9678b7fb124e57af5f1be2328c292d
Akademický článek
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Publikováno v:
Am J Transplant
Thymic output and homeostatic mature cell proliferation both influence T cell repopulation following depletional induction, though the relative contribution of each and their association with recipient age have not been well studied. We investigated
Publikováno v:
Histochemistry and Cell Biology
Immunosuppressive drugs such as cyclosporine A (CSA) can disrupt thymic structure and functions, ultimately inducing syngeneic/autologous graft-versus-host disease together with involuted medullas. To elucidate the effects of CSA on the thymus more p
Autor:
Nelli Heikkilä, Iivo Hetemäki, Silja Sormunen, Helena Isoniemi, Eliisa Kekäläinen, Jari Saramäki, T. Petteri Arstila
Funding Information: We thank the nurses of the Transplantation Unit of Helsinki University Central Hospital, HiLife Flow Cytometry Unit of University of Helsinki, and Tamás Bazsinka for technical support. This study has been funded by Emil Aaltonen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b75079f1c418aea26553c2913ea205e
http://hdl.handle.net/10138/346130
http://hdl.handle.net/10138/346130
Autor:
Marcel R.M. van den Brink, Christopher P. Coplen, Jennifer L. Uhrlaub, Bonnie LaFleur, Sandip Ashok Sonar, Janko Nikolich-Zugich, Mladen Jergović, Gregory D. Sempowski, Jarrod A Dudakov
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(17)
Secondary lymphoid organs (SLO; including the spleen and lymph nodes) are critical both for the maintenance of naïve T (TN) lymphocytes and for the initiation and coordination of immune responses. How they age, including the exact timing, extent, ph
Publikováno v:
BMC Surgery, Vol 21, Iss 1, Pp 1-6 (2021)
BMC Surgery
BMC Surgery
Background Chemotherapy can cause thymic atrophy and reduce T-cell output in cancer patients. However, the thymus in young adult patients has regenerative potential after chemotherapy, manifesting as thymic hyperplasia which can be easily mistaken as
Autor:
Aldona Wierzbicka, Izabela Kubiszewska, Mieczysław Litwin, Lidia Gackowska, Anna Niemirska, Lukasz Obrycki, Jacek Michałkiewicz, Maciej Kłosowski, Anna Helmin-Basa
Publikováno v:
Journal of Hypertension. 38:692-700
Background The relationship between circulating regulatory T-cell (Tregs) subset distribution and hypertension severity in children with primary hypertension is not known. We aimed to find out if target organ damage (TOD) in children with primary hyp
Autor:
Gustavo Reyes-Terán, Daniela Garrido-Rodríguez, Olivia Briceño, Amy Peralta-Prado, Monserrat Chávez-Torres, Sandra Pinto-Cardoso, Karla Romero-Mora
Publikováno v:
AIDS (London, England)
Supplemental Digital Content is available in the text
Objective: Around 20–30% of HIV-infected individuals (HIV+) on successful antiretroviral therapy (ART) fail to normalize their CD4+ T-cell counts. Various factors could contribute to the la
Objective: Around 20–30% of HIV-infected individuals (HIV+) on successful antiretroviral therapy (ART) fail to normalize their CD4+ T-cell counts. Various factors could contribute to the la
Publikováno v:
Immunity & Ageing, Vol 17, Iss 1, Pp 1-10 (2020)
Immunity & Ageing : I & A
Immunity and Ageing, 17(1):4. BioMed Central Ltd.
Immunity & Ageing : I & A
Immunity and Ageing, 17(1):4. BioMed Central Ltd.
BackgroundEnd-stage renal disease is associated with premature ageing of the T cell immune system but inter-individual variation is substantial. The hypothesis was tested that advanced immunological T cell ageing assessed by peripheral T cell differe