Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Rebika Shrestha"'
Autor:
Rebika Shrestha, Timothy S. Carpenter, Que N. Van, Constance Agamasu, Marco Tonelli, Fikret Aydin, De Chen, Gulcin Gulten, James N. Glosli, Cesar A. López, Tomas Oppelstrup, Chris Neale, Sandrasegaram Gnanakaran, William K. Gillette, Helgi I. Ingólfsson, Felice C. Lightstone, Andrew G. Stephen, Frederick H. Streitz, Dwight V. Nissley, Thomas J. Turbyville
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-16 (2024)
Abstract The oncogene RAS, extensively studied for decades, presents persistent gaps in understanding, hindering the development of effective therapeutic strategies due to a lack of precise details on how RAS initiates MAPK signaling with RAF effecto
Externí odkaz:
https://doaj.org/article/c9c372b885d34294a1a4b151fe83ce95
Autor:
Rebika Shrestha, Timothy S. Carpenter, Que N. Van, Constance Agamasu, Marco Tonelli, Fikret Aydin, De Chen, Gulcin Gulten, James N. Glosli, Cesar A. López, Tomas Oppelstrup, Chris Neale, Sandrasegaram Gnanakaran, William K. Gillette, Helgi I. Ingólfsson, Felice C. Lightstone, Andrew G. Stephen, Frederick H. Streitz, Dwight V. Nissley, Thomas J. Turbyville
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/ebd31f95883b42a68c6081c546cb6fe3
Publikováno v:
iScience, Vol 25, Iss 1, Pp 103608- (2022)
Summary: Understanding the spatiotemporal distribution and dynamics of RAS on the plasma membrane (PM) is the key for elucidating the molecular mechanisms of the RAS signaling pathway. Single particle tracking (SPT) experiments show that in cells, KR
Externí odkaz:
https://doaj.org/article/b2082f6fe93940f0966c6fc4a2000b8a
Autor:
Que N. Van, Priyanka Prakash, Rebika Shrestha, Trent E. Balius, Thomas J. Turbyville, Andrew G. Stephen
Publikováno v:
Biomolecules, Vol 11, Iss 3, p 377 (2021)
RAS proteins are mutated in approximately 20% of all cancers and are generally associated with poor clinical outcomes. RAS proteins are localized to the plasma membrane and function as molecular switches, turned on by partners that receive extracellu
Externí odkaz:
https://doaj.org/article/398a71e792b1472fa938e22953542dcb
Autor:
Helgi I. Ingólfsson, Harsh Bhatia, Fikret Aydin, Tomas Oppelstrup, Cesar A. López, Liam G. Stanton, Timothy S. Carpenter, Sergio Wong, Francesco Di Natale, Xiaohua Zhang, Joseph Y. Moon, Christopher B. Stanley, Joseph R. Chavez, Kien Nguyen, Gautham Dharuman, Violetta Burns, Rebika Shrestha, Debanjan Goswami, Gulcin Gulten, Que N. Van, Arvind Ramanathan, Brian Van Essen, Nicolas W. Hengartner, Andrew G. Stephen, Thomas Turbyville, Peer-Timo Bremer, S. Gnanakaran, James N. Glosli, Felice C. Lightstone, Dwight V. Nissley, Frederick H. Streitz
Publikováno v:
Journal of Chemical Theory and Computation. 19:2658-2675
Autor:
Cesar A. López, Xiaohua Zhang, Fikret Aydin, Rebika Shrestha, Que N. Van, Christopher B. Stanley, Timothy S. Carpenter, Kien Nguyen, Lara A. Patel, De Chen, Violetta Burns, Nicolas W. Hengartner, Tyler J. E. Reddy, Harsh Bhatia, Francesco Di Natale, Timothy H. Tran, Albert H. Chan, Dhirendra K. Simanshu, Dwight V. Nissley, Frederick H. Streitz, Andrew G. Stephen, Thomas J. Turbyville, Felice C. Lightstone, Sandrasegaram Gnanakaran, Helgi I. Ingólfsson, Chris Neale
Publikováno v:
Journal of Chemical Theory and Computation. 18:5025-5045
The appeal of multiscale modeling approaches is predicated on the promise of combinatorial synergy. However, this promise can only be realized when distinct scales are combined with reciprocal consistency. Here, we consider multiscale molecular dynam
Autor:
Rebika Shrestha, Thomas J. Turbyville, Torin McDonald, Valerio Pascucci, Harsh Bhatia, Peer-Timo Bremer, Xiyu Yi, De Chen, Debanjan Goswami
Publikováno v:
Computer Graphics Forum. 40:251-262
Autor:
Xiyu Yi, Rebika Shrestha, Torin McDonald, De Chen, Harsh Bhatia, Valerio Pascucci, Thomas Turbyville, Peer-Timo Bremer
Single particle tracking (SPT) is an indispensable tool for scientific studies. However, SPT for datasets with a high density of particles is still challenging, especially for the study of particle interactions where the point spread functions (PSFs)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c708c279b139a21558847fe7c1631276
https://doi.org/10.1101/2022.05.13.491828
https://doi.org/10.1101/2022.05.13.491828
Autor:
Kien Nguyen, Cesar A. López, Chris Neale, Que N. Van, Timothy S. Carpenter, Francesco Di Natale, Timothy Travers, Timothy H. Tran, Albert H. Chan, Harsh Bhatia, Peter H. Frank, Marco Tonelli, Xiaohua Zhang, Gulcin Gulten, Tyler Reddy, Violetta Burns, Tomas Oppelstrup, Nick Hengartner, Dhirendra K. Simanshu, Peer-Timo Bremer, De Chen, James N. Glosli, Rebika Shrestha, Thomas Turbyville, Frederick H. Streitz, Dwight V. Nissley, Helgi I. Ingólfsson, Andrew G. Stephen, Felice C. Lightstone, Sandrasegaram Gnanakaran
Publikováno v:
Biophysical journal. 121(19)
During the activation of mitogen-activated protein kinase (MAPK) signaling, the RAS-binding domain (RBD) and cysteine-rich domain (CRD) of RAF bind to active RAS at the plasma membrane. The orientation of RAS at the membrane may be critical for forma
Autor:
Harsh Bhatia, Dwight V. Nissley, Arthur F. Voter, Helgi I. Ingólfsson, Frank McCormick, Sumantra Sarkar, Debanjan Goswami, Gulcin Gulten, Timothy S. Carpenter, Sara Kokkila Schumacher, Frederick H. Streitz, Peer-Timo Bremer, Jeevapani J. Hettige, Xiaohua Zhang, Liam Stanton, Shusen Liu, Yue Yang, Arvind Ramanathan, Nicolas W. Hengartner, Timothy H. Tran, Dhirendra K. Simanshu, Thomas J. Turbyville, Rebika Shrestha, Constance Agamasu, Shiv Sundram, Michael P. Surh, Brian Van Essen, Cesar A. Lopez, Tomas Oppelstrup, Timothy Travers, James N. Glosli, Felice C. Lightstone, Andrew G. Stephen, Frantz Jean-Francios, De Chen, Chris Neale, Que Van, Sandrasegaram Gnanakaran, Francesco Di Natale, Adam Moody, Gautham Dharuman, Animesh Agarwal
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 119, iss 1
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America
Significance Here we present an unprecedented multiscale simulation platform that enables modeling, hypothesis generation, and discovery across biologically relevant length and time scales to predict mechanisms that can be tested experimentally. We d