Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Rebekka A. Schwab"'
Autor:
Samuel C. Griffiths, Rebekka A. Schwab, Kamel El Omari, Benjamin Bishop, Ellen J. Iverson, Tomas Malinauskas, Ramin Dubey, Mingxing Qian, Douglas F. Covey, Robert J. C. Gilbert, Rajat Rohatgi, Christian Siebold
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Hedgehog-Interacting Protein (HHIP) is the only reported secreted inhibitor of Sonic Hedgehog (SHH) signalling. Here, the authors report structures of the HHIP N- and C-terminal domains, both in complexes with glycosaminoglycans, providing insights i
Externí odkaz:
https://doaj.org/article/420c08df587c4e738a4706dedda2d860
Autor:
Keiko Yata, Jean-Yves Bleuyard, Ryuichiro Nakato, Christine Ralf, Yuki Katou, Rebekka A. Schwab, Wojciech Niedzwiedz, Katsuhiko Shirahige, Fumiko Esashi
Publikováno v:
Cell Reports, Vol 7, Iss 5, Pp 1547-1559 (2014)
Numerous human genome instability syndromes, including cancer, are closely associated with events arising from malfunction of the essential recombinase Rad51. However, little is known about how Rad51 is dynamically regulated in human cells. Here, we
Externí odkaz:
https://doaj.org/article/b74b4e6518364c7ea181813928cbc69e
Autor:
Claire E. Coupland, Sebastian A. Andrei, T. Bertie Ansell, Loic Carrique, Pramod Kumar, Lea Sefer, Rebekka A. Schwab, Eamon F.X. Byrne, Els Pardon, Jan Steyaert, Anthony I. Magee, Thomas Lanyon-Hogg, Mark S.P. Sansom, Edward W. Tate, Christian Siebold
Publikováno v:
Molecular Cell
Summary The Sonic Hedgehog (SHH) morphogen pathway is fundamental for embryonic development and stem cell maintenance and is implicated in various cancers. A key step in signaling is transfer of a palmitate group to the SHH N terminus, catalyzed by t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4126d9db15243ce2d4d7d77c45ec15bc
https://pubmed.ncbi.nlm.nih.gov/34890564
https://pubmed.ncbi.nlm.nih.gov/34890564
Autor:
Armin Wagner, Douglas F. Covey, Jan Steyaert, Rebekka A. Schwab, Els Pardon, Tomas Malinauskas, Rajat Rohatgi, Christian Siebold, Mark S.P. Sansom, A.F. Rudolf, Kamel El Omari, Ramona Duman, Mingxing Qian, C. Kowatsch, T. Bertie Ansell, B. Bishop, Maia Kinnebrew
Publikováno v:
Nature chemical biology
Nature Chemical Biology
Nature Chemical Biology
Hedgehog (HH) ligands, classical morphogens that pattern embryonic tissues in all animals, are covalently coupled to two lipids—a palmitoyl group at the N terminus and a cholesteroyl group at the C terminus. While the palmitoyl group binds and inac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::643843aec6121605e89ece3eeb0d11fb
http://europepmc.org/articles/PMC6764859
http://europepmc.org/articles/PMC6764859
Autor:
Jadwiga, Nieminuszczy, Ronan, Broderick, Marina A, Bellani, Elizabeth, Smethurst, Rebekka A, Schwab, Veronica, Cherdyntseva, Theodora, Evmorfopoulou, Yea-Lih, Lin, Michal, Minczuk, Philippe, Pasero, Sarantis, Gagos, Michael M, Seidman, Wojciech, Niedzwiedz
Publikováno v:
Molecular Cell
Summary Accurate DNA replication is essential to preserve genomic integrity and prevent chromosomal instability-associated diseases including cancer. Key to this process is the cells’ ability to stabilize and restart stalled replication forks. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fb1bdb4e7d117c70518a8dbe39e4911a
https://pubmed.ncbi.nlm.nih.gov/31255466
https://pubmed.ncbi.nlm.nih.gov/31255466
Publikováno v:
The Journal of Cell Biology
The FANCJ helicase promotes DNA replication in trans by counteracting fork stalling at replication barriers and suppresses heterochromatin spreading by coupling fork movement with maintenance of chromatin structure.
Defective DNA repair causes F
Defective DNA repair causes F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45ccff38292e68b55df19177af760bc7
http://europepmc.org/articles/PMC3613694
http://europepmc.org/articles/PMC3613694
Publikováno v:
Methods (San Diego, Calif.). 108
Faithful duplication of genetic material during every cell division is essential to ensure accurate transmission of genetic information to daughter cells. DNA helicases play a crucial role in promoting this process by facilitating almost all transact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2ae30d1c8f6a1e5a7522401b66c9f303
https://pubmed.ncbi.nlm.nih.gov/27102626
https://pubmed.ncbi.nlm.nih.gov/27102626
Autor:
Andrew N. Blackford, Stephen C. West, Rebekka A. Schwab, Wojciech Niedzwiedz, Jadwiga Nieminuszczy, Andrew J. Deans
Publikováno v:
Human Molecular Genetics. 21:2005-2016
FANCM is the most highly conserved protein within the Fanconi anaemia (FA) tumour suppressor pathway. However, although FANCM contains a helicase domain with translocase activity, this is not required for its role in activating the FA pathway. Instea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5810cf3acf2c3599454aff221e0cefc5
https://doi.org/10.1093/hmg/dds013
https://doi.org/10.1093/hmg/dds013
Publikováno v:
The EMBO Journal. 29:806-818
Fanconi anaemia is a chromosomal instability disorder associated with cancer predisposition and bone marrow failure. Among the 13 identified FA gene products only one, the DNA translocase FANCM, has homologues in lower organisms, suggesting a conserv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ec9b239447d134874c365b325d74919
https://doi.org/10.1038/emboj.2009.385
https://doi.org/10.1038/emboj.2009.385
Autor:
Chih-Chao Liang, Jamie Langton, Andrew J. Deans, Fenil Shah, Richard J. Gibbons, Martin A. Cohn, Jadwiga Nieminuszczy, Wojciech Niedzwiedz, Rebekka A. Schwab, David Lopez Martinez
Publikováno v:
Molecular cell. 60(3)
DNA replication stress can cause chromosomal instability and tumor progression. One key pathway that counteracts replication stress and promotes faithful DNA replication consists of the Fanconi anemia (FA) proteins. However, how these proteins limit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb3a621f5d5230b24f3f0930a1d83b2c
https://pubmed.ncbi.nlm.nih.gov/26563463
https://pubmed.ncbi.nlm.nih.gov/26563463