Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Rebekka, Grundler"'
Autor:
Tobias Dechow, Justus Duyster, Christian Peschel, Jens T. Siveke, Falko Fend, Marcus Kremer, Rebekka Grundler, Tibor Schuster, Ina Koch, Katja Specht, Nicole Schatz, Nadya Mitova, Lars Michel, Petros Vlachou, Stefan Seidl, Anja Baumgart
Supplementary Figure 1, Tables 1-7 from ADAM17 Regulates Epidermal Growth Factor Receptor Expression through the Activation of Notch1 in Non–Small Cell Lung Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19f5d4193ed64d9454616afdcce69b6f
https://doi.org/10.1158/0008-5472.22384496.v1
https://doi.org/10.1158/0008-5472.22384496.v1
Autor:
Lars Bullinger, Nadya Mitova, Ulrich Keller, Christian Peschel, Katharina Götze, Jan Bauer, Stefan Rose-John, Tobias Dechow, Markus Thaler, Sabine Steidle, Corinna Albers, Falko Fend, Valeria Soberon, Martina Rudelius, Justus Duyster, Zhoulei Li, Susanne Kratzat, Elke Pietschmann, Florian Bassermann, Kerstin Behnke, Konstanze Pechloff, Marc Schmidt-Supprian, Jürgen Ruland, Rebekka Grundler
Publikováno v:
Journal of Clinical Investigation. 124:5263-5274
Multiple myeloma (MM) is a plasma cell neoplasm that results from clonal expansion of an Ig-secreting terminally differentiated B cell. Advanced MM is characterized by tissue damage that involves bone, kidney, and other organs and is typically associ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d94ee1b5eb3137893c98aa2e97441f3
https://doi.org/10.1172/jci69094
https://doi.org/10.1172/jci69094
Autor:
Christiane Katzerke, Dietger Niederwieser, Carsten Müller-Tidow, Daniel G. Tenen, Vikas Madan, Alexander Arthur Wurm, Dennis Gerloff, Gerhard Behre, Rebekka Grundler, J-U Hartmann, Daniela Bräuer-Hartmann, Justus Duyster
Publikováno v:
Leukemia. 29:535-547
Almost 30% of all acute myeloid leukemias (AML) are associated with an internal tandem duplication (ITD) in the juxtamembrane domain of FMS-like tyrosine kinase 3 receptor (FLT3). Patients with FLT3-ITD mutations tend to have a poor prognosis. MicroR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cedb04d7a03c0c3383745f568c675f6d
https://doi.org/10.1038/leu.2014.231
https://doi.org/10.1038/leu.2014.231
Autor:
Christian Peschel, Rebekka Grundler, Lars Rönnstrand, Katharina Götze, Elena Razumovskaya, Karsten Spiekermann, Hannes Leischner, Justus Duyster, Stefan K. Bohlander, Corinna Albers
Publikováno v:
Blood. 119:4026-4033
Mutations of Fms-like tyrosine kinase 3 (FLT3) are among the most frequently detected molecular abnormalities in AML patients. Internal tandem duplications (ITDs) are found in approximately 25% and point mutations within the second tyrosine kinase do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cdfce3a00c12b9422e5fb12ff185dc7
https://doi.org/10.1182/blood-2011-07-365726
https://doi.org/10.1182/blood-2011-07-365726
Autor:
Christian Meyer zum Büschenfelde, Christian Peschel, Justus Duyster, Marcus Kremer, Anna Lena Illert, Sivahari P. Gorantla, Tobias Dechow, Rebekka Grundler
Publikováno v:
Blood. 116:4600-4611
The oncogenic JAK2V617F mutation is found in myeloproliferative neoplasms (MPNs) and is believed to be critical for leukemogenesis. Here we show that JAK2V617F requires an intact SH2 domain for constitutive activation of downstream signaling pathways
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc0dee9ecee8fe9eec663e0e3f957859
https://doi.org/10.1182/blood-2009-07-236133
https://doi.org/10.1182/blood-2009-07-236133
Autor:
Claudia Mugler, Christian Peschel, Oliver G. Ottmann, Jochen B. Geigl, Rebekka Grundler, Justus Duyster, Cornelius Miething, Michael R. Speicher, J Hoepfl, Simone Brero
Publikováno v:
Proceedings of the National Academy of Sciences. 104:4594-4599
The kinase inhibitor imatinib mesylate targeting the oncoprotein Bcr-Abl has revolutionized the treatment of chronic myeloid leukemia (CML). However, even though imatinib successfully controls the leukemia in chronic phase, it seems not to be able to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89844238b5719638bc1a6f2b49c4fba7
https://doi.org/10.1073/pnas.0604716104
https://doi.org/10.1073/pnas.0604716104
Autor:
N von Bubnoff, Justus Duyster, Rebekka Grundler, Cornelius Miething, Claudia Mugler, Christian Peschel, Florian Lordick, S Feihl
Publikováno v:
Leukemia. 20:650-657
Mutations in the Bcr-Abl kinase domain are a frequent cause of imatinib resistance in patients with advanced CML or Ph+ ALL. The impact of these mutations on the overall oncogenic potential of Bcr-Abl and on the clinical course of the disease in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cc2f6c10a29686debaecb93a3b01940
https://doi.org/10.1038/sj.leu.2404151
https://doi.org/10.1038/sj.leu.2404151
Autor:
Christian Thiede, Justus Duyster, Christine Steudel, Christian Peschel, Cornelius Miething, Rebekka Grundler
Publikováno v:
Blood. 102:646-651
Activating mutations of FLT3 have been detected in patients with acute myeloid leukemia (AML). Two distinct types of FLT3 mutations are most common: internal tandem duplication (ITD) of sequences coding for the juxtamembrane domain and point mutation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1544d3a97a9d396c4650f6634f67a7e
https://doi.org/10.1182/blood-2002-11-3441
https://doi.org/10.1182/blood-2002-11-3441
Autor:
Anja Baumgart, Falko Fend, Ina Koch, Nadya Mitova, Tobias Dechow, Justus Duyster, Lars Michel, Marcus Kremer, Petros Vlachou, Jens T. Siveke, Nicole Schatz, Tibor Schuster, Christian Peschel, Rebekka Grundler, Katja Specht, Stefan Seidl
Publikováno v:
Cancer research. 70(13)
Epidermal growth factor receptor (EGFR) overexpression and activation are hallmarks of non–small cell lung carcinoma (NSCLC). Although EGFR-targeted therapies are used, the prognosis of NSCLC remains poor. ADAM17 induces activation of the EGFR thro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30d273b2b70cffcf0a3b2176cecceb51
https://pubmed.ncbi.nlm.nih.gov/20551051
https://pubmed.ncbi.nlm.nih.gov/20551051
Autor:
Srinivasa Rao, Bandi, Christian, Brandts, Marion, Rensinghoff, Rebekka, Grundler, Lara, Tickenbrock, Gabriele, Köhler, Justus, Duyster, Wolfgang E, Berdel, Carsten, Müller-Tidow, Hubert, Serve, Bülent, Sargin, Martin, Wolf
Publikováno v:
Blood. 114(19)
Somatic mutations of Kit have been found in leukemias and gastrointestinal stromal tumors. The proto-oncogene c-Cbl negatively regulates Kit and Flt3 by its E3 ligase activity and acts as a scaffold. We recently identified the first c-Cbl mutation in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52f962fcabe75449442e91edcfe3aaa3
https://pubmed.ncbi.nlm.nih.gov/19734451
https://pubmed.ncbi.nlm.nih.gov/19734451