Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Rebekah Tillotson"'
Autor:
Rebekah Tillotson, Keqin Yan, Julie Ruston, Taylor de Young, Alex Córdova, Valérie Turcotte- Cardin, Yohan Yee, Christine Taylor, Shagana Visuvanathan, Christian Babbs, Evgueni A Ivakine, John G Sled, Brian J Nieman, David J Picketts, Monica J Justice
Publikováno v:
Human Molecular Genetics.
ATRX is a chromatin remodelling ATPase that is involved in transcriptional regulation, DNA damage repair and heterochromatin maintenance. It has been widely studied for its role in ALT-positive cancers, but its role in neurological function remains e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5deafe9293a06140aac6f5c50adfcedd
https://doi.org/10.1093/hmg/ddad075
https://doi.org/10.1093/hmg/ddad075
Autor:
Adrian Bird, Rebekah Tillotson
Publikováno v:
J Mol Biol
Tillotson, R & Bird, A 2020, ' The molecular basis of MeCP2 function in the brain ', Journal of Molecular Biology, vol. 432, no. 6 . https://doi.org/10.1016/j.jmb.2019.10.004
Tillotson, R & Bird, A 2020, ' The molecular basis of MeCP2 function in the brain ', Journal of Molecular Biology, vol. 432, no. 6 . https://doi.org/10.1016/j.jmb.2019.10.004
MeCP2 is a reader of the DNA methylome that occupies a large proportion of the genome due to its high abundance and the frequency of its target sites. It has been the subject of extensive study because of its link with 'MECP2-related disorders', of w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aa927eedac9388103844f0e14f9b312
https://doi.org/10.1016/j.jmb.2019.10.004
https://doi.org/10.1016/j.jmb.2019.10.004
Autor:
Jim Selfridge, Martha V. Koerner, Stuart Cobb, Ralph D. Hector, Adrian Bird, Kamal K.E. Gadalla, Diana De Sousa, Rebekah Tillotson, Jacky Guy
Publikováno v:
Tillotson, R, Selfridge, J, Koerner, M V, Gadalla, K K E, Guy, J, Sousa, D D, Hector, R D, Cobb, S R & Bird, A 2017, ' Radically truncated MeCP2 rescues Rett syndrome-like neurological defects ', Nature, vol. 550, pp. 398-401 . https://doi.org/10.1038/nature24058
Nature
Nature
Heterozygous mutations in the X-linked MECP2 gene cause the neurological disorder Rett syndrome1. The methyl-CpG-binding protein 2 (MeCP2) protein is an epigenetic reader whose binding to chromatin primarily depends on 5-methylcytosine2, 3. Functiona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8baa1c6db53ce914041a3565714eceed
https://doi.org/10.1038/nature24058
https://doi.org/10.1038/nature24058
Autor:
Rebekah Tillotson, Dina De Sousa, Martha V. Koerner, Jacky Guy, Matthew J. Lyst, Mitchell A. Lazar, Jim Selfridge, Laura FitzPatrick, Alastair R.W. Kerr, Zheng Sun, Adrian Bird
Publikováno v:
Koerner, M V, Fitzpatrick, L, Selfridge, J, Guy, J, De Sousa, D, Tillotson, R, Kerr, A, Sun, Z, Lazar, M A, Lyst, M J & Bird, A 2018, ' Toxicity of overexpressed MeCP2 is independent of HDAC3 activity ', Genes & Development, vol. 32, no. 23-24, pp. 1514-1524 . https://doi.org/10.1101/gad.320325.118
Duplication of the X-linked MECP2 gene causes a severe neurological syndrome whose molecular basis is poorly understood. To determine the contribution of known functional domains to overexpression toxicity, we engineered a mouse model that expresses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f9e9a5b5c6aff5436cc29cf6104de48
https://www.pure.ed.ac.uk/ws/files/80488137/Toxicity_of_overexpressed_PUB_OA_CC_BY_Genes_Dev._2018_Koerner_1514_24.pdf
https://www.pure.ed.ac.uk/ws/files/80488137/Toxicity_of_overexpressed_PUB_OA_CC_BY_Genes_Dev._2018_Koerner_1514_24.pdf
Autor:
Skirmantas Kriaucionis, Matthew J. Lyst, John C. Connelly, Shaun Webb, Jim Selfridge, Justyna Cholewa-Waclaw, Adrian Bird, Martha V. Koerner, Rebekah Tillotson, David A. Kelly, Sophie A. Kirschner, Kashyap Chhatbar, Kyla Brown, Dina De Sousa
Publikováno v:
Mol Cell
Molecular Cell
Tillotson, R, Cholewa-Waclaw, J, Chhatbar, K, Connelly, J, Kirschner, S A, Webb, S, Koerner, M, Selfridge, J, Kelly, D, De Sousa, D, Brown, K, Lyst, M J, Kriaucionis, S & Bird, A P 2021, ' Neuronal non-CG methylation is an essential target for MeCP2 function ', Molecular Cell, vol. 81, no. 6, pp. P1260-1275.E12 . https://doi.org/10.1016/j.molcel.2021.01.011
Molecular Cell
Tillotson, R, Cholewa-Waclaw, J, Chhatbar, K, Connelly, J, Kirschner, S A, Webb, S, Koerner, M, Selfridge, J, Kelly, D, De Sousa, D, Brown, K, Lyst, M J, Kriaucionis, S & Bird, A P 2021, ' Neuronal non-CG methylation is an essential target for MeCP2 function ', Molecular Cell, vol. 81, no. 6, pp. P1260-1275.E12 . https://doi.org/10.1016/j.molcel.2021.01.011
Summary DNA methylation is implicated in neuronal biology via the protein MeCP2, the mutation of which causes Rett syndrome. MeCP2 recruits the NCOR1/2 co-repressor complexes to methylated cytosine in the CG dinucleotide, but also to sites of non-CG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0b3a23657fffed415a5ae575c09857a