Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Rebekah R. Bartelt"'
Publikováno v:
PLoS ONE, Vol 4, Iss 5, p e5430 (2009)
BACKGROUND: Human T cells play an important role in pathogen clearance, but their aberrant activation is also linked to numerous diseases. T cells are activated by the concurrent induction of the T cell receptor (TCR) and one or more costimulatory re
Externí odkaz:
https://doaj.org/article/e1baa073acb140b48b0f99060c149a59
Autor:
Aldo Vacaflores, Piers Nash, Jonathan Light, Jon C. D. Houtman, Rebekah R. Bartelt, Alayna K. Butcher, Madhana Pandian
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1853(10):2560-2569
SH3 domains are evolutionarily conserved protein interaction domains that control nearly all cellular processes in eukaryotes. The current model is that most SH3 domains bind discreet PxxPxR motifs with weak affinity and relatively low selectivity. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60448937bc0e09aacbf2ba319f23ccef
Autor:
Jon C. D. Houtman, Rebekah R. Bartelt
Publikováno v:
WIREs Systems Biology and Medicine. 5:101-110
T cells are essential for the adaptive immune response to pathogens. However, dysfunctional T cell activity has been implicated in numerous diseases, including the failure of organ transplants, allergic reactions, asthma, autoimmune disorders, and co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::218d08738b10639d5a2c94b54421adb2
https://doi.org/10.1002/wsbm.1194
https://doi.org/10.1002/wsbm.1194
Publikováno v:
Molecular Immunology. 47:1665-1674
The tyrosine kinase Pyk2 integrates receptor-mediated signals controlling actin cytoskeletal rearrangement, events needed for the activation and function of T cells. Induction of the T cell receptor (TCR) leads to the phosphorylation of Pyk2, but the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::060ce615fc6e9ff4f1439d33ddc5b4ed
https://doi.org/10.1016/j.molimm.2010.03.009
https://doi.org/10.1016/j.molimm.2010.03.009
Publikováno v:
PLoS ONE
PLoS ONE, Vol 4, Iss 5, p e5430 (2009)
PLoS ONE, Vol 4, Iss 5, p e5430 (2009)
Background Human T cells play an important role in pathogen clearance, but their aberrant activation is also linked to numerous diseases. T cells are activated by the concurrent induction of the T cell receptor (TCR) and one or more costimulatory rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d9d68b70c67ddf17b3e481068175aae
https://pubmed.ncbi.nlm.nih.gov/19412549
https://pubmed.ncbi.nlm.nih.gov/19412549