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Impact of molecular medicine on neuropsychiatry: The clinician’s perspective

Publikováno v: Current Psychiatry Reports. 3:355-360

Clinical neuropsychiatry has traditionally relied on individual practitioner experience or the apprentice-training model for formulating cases and choosing treatment. Scientifically-based diagnostic criteria and treatment algorithms have been lacking

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10f433a571108120625509f069051826
https://doi.org/10.1007/s11920-996-0026-y

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Pharmacologic therapy for behavioral symptoms of alzheimer's disease

Autor: Pierre N. Tariot, Lon S. Schneider, Rebekah Loy, J. Michael Ryan, Anton P. Porsteinsson

Publikováno v: Clinics in Geriatric Medicine. 17:359-376

Behavioral signs and symptoms in dementia are common, morbid, classifiable, and treatable. The current state-of-the-art approach is to evaluate carefully for social or environmental causes, intercurrent medical conditions, or other triggers of the be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba4764c235e5dc55b54fc225b806aa12
https://doi.org/10.1016/s0749-0690(05)70073-2

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Prenatal Availability of Choline Alters the Development of Acetylcholinesterase in the Rat Hippocampus

Autor: Rebekah Loy, Jennifer M. Cermak, Warren H. Meck, Jan Krzysztof Blusztajn, Christina L. Williams, Claudia M. Fitzgerald, Douglas L. Rosene

Publikováno v: Developmental Neuroscience. 21:94-104

Choline (Ch) supplementation during embryonic days (ED) 12–17 enhances spatial and temporal memory in adult and aged rats, whereas prenatal Ch deficiency impairs attention performance and accelerates age-related declines in temporal processing. To

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb457688f98efb5f8edf9336e64bcf1f
https://doi.org/10.1159/000017371

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Retrograde Axonal Transport and Lesion-Induced Upregulation of the TrkA High-Affinity NGF Receptor

Autor: Alonzo H. Ross, Dorota K. Poluha, Peter J. Condon, Mahesh Lachyankar, Rebekah Loy

Publikováno v: Experimental Neurology. 130:377-386

Long-term physiological responses of nerve growth factor (NGF) and other neurotrophins require gene regulation and likely depend on retrograde axonal transport of NGF or a signaling molecule activated by ligand-receptor interaction. The low-affinity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc5549b829b092c098606ef281e00810
https://doi.org/10.1006/exnr.1994.1217

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Regional CNS uptake of blood-borne nerve growth factor

Autor: D. Heyer, L. Angelucci, Giulio Taglialatela, Rebekah Loy, Regino Perez-Polo

Publikováno v: Journal of Neuroscience Research. 39:339-346

Nerve growth factor (NGF), in addition to being a neurotrophic substance, has effects on the endocrine and immune systems. For example, intravenous injection of NGF results in a cascade of events leading to an increase in glucocorticoid secretion. Wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4511dc47b1c32a0557343b784d6aed04
https://doi.org/10.1002/jnr.490390311

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Relationship of APP mRNA transcripts and levels of NGF and low-affinity NGF receptors to behavioral measures of age-related cognitive dysfunction

Autor: SI Dworetzky, C Sampson, Rebekah Loy, Lindner

Publikováno v: Scopus-Elsevier

This study was designed to examine the relationship between cognitive function and endogenous levels of NGF, low-affinity NGF receptor (LNGFR), and amyloid precursor protein (APP) mRNAs. Using 3 month (n = 5), 18 month (n = 40), and 29 month (n = 17)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee5ce6345337d30f4d0200346dd78b36
https://doi.org/10.1523/jneurosci.14-04-02282.1994

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Increased Levels of Truncated Nerve Growth Factor Receptor in Urine of Mildly Demented Patients With Alzheimer's Disease

Autor: Robert W. Hamill, Peter S. DiStefano, Mark D. Lindner, Pierre N. Tariot, Rebekah Loy, Deidre D. Gordon, Keith D. McDaniel, Judith M. Miller

Publikováno v: Archives of Neurology. 50:1054-1058

• Objective. —In Alzheimer's disease, cholinergic basal forebrain neurons, which have receptors for nerve growth factor (NGF), degenerate, while NGF receptors increase in some areas of the neocortex. Levels of the truncated, extracellular portion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e2906aa0a1872f1ba0d497ae504bbb1
https://doi.org/10.1001/archneur.1993.00540100049013

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Proteomic analysis of peripheral leukocytes in Alzheimer's disease patients treated with divalproex sodium

Autor: Louis A. Profenno, Timothy R. Mhyre, Howard J. Federoff, Kathleen A. Maguire-Zeiss, Pierre N. Tariot, Paul D. Coleman, Rebekah Loy, Dabao Zhang

Publikováno v: Neurobiology of aging. 29(11)

The molecular profiling of peripheral tissues, including circulating leukocytes, may hold promise in the discovery of biomarkers for diagnosing and treating neurodegenerative diseases, including Alzheimer's disease (AD). As a proof-of-concept, we per

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32eb9ed5404c15f475a9ff0c5d8307e2
https://pubmed.ncbi.nlm.nih.gov/17521776

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