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pro vyhledávání: '"Rebekah J. Nicholson"'
Autor:
Marie K. Norris, Trevor S. Tippetts, Joseph L. Wilkerson, Rebekah J. Nicholson, J. Alan Maschek, Thierry Levade, Jeffrey A. Medin, Scott A. Summers, William L. Holland
Publikováno v:
Molecular Genetics and Metabolism Reports, Vol 39, Iss , Pp 101077- (2024)
Farber Disease is a debilitating and lethal childhood disease of ceramide accumulation caused by acid ceramidase deficiency. The potent induction of a ligand-gated neutral ceramidase activity promoted by adiponectin may provide sufficient lowering of
Externí odkaz:
https://doaj.org/article/fd1f0a9001544ffca316b6e632fe7b03
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2021)
Diabetic kidney disease (DKD) is a prevalent and progressive comorbidity of diabetes mellitus that increases one’s risk of developing renal failure. Progress toward development of better DKD therapeutics is limited by an incomplete understanding of
Externí odkaz:
https://doaj.org/article/3189551a9c05419bae9c9ee47c45def2
Publikováno v:
Seminars in nephrology. 42(3)
Altered lipid metabolism is a characteristic feature and potential driving factor of acute kidney injury (AKI). Of the lipids that accumulate in injured renal tissues, ceramides are potent regulators of metabolism and cell fate. Up-regulation of cera
Autor:
Rebekah J. Nicholson, Marie K. Norris, Annelise M. Poss, William L. Holland, Scott A. Summers
Publikováno v:
Annu Rev Nutr
Diet influences onset, progression, and severity of several chronic diseases, including heart failure, diabetes, steatohepatitis, and a subset of cancers. The prevalence and clinical burden of these obesity-linked diseases has risen over the past two
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c107249c3460b1f1cf6dcf92e467167
https://europepmc.org/articles/PMC9399075/
https://europepmc.org/articles/PMC9399075/
Publikováno v:
Trends Endocrinol Metab
Recent research by Miguel et al. and Dhillon et al. reveals associations between impaired lipid metabolism and kidney fibrosis. Kidney tubule fatty acid oxidation (FAO) gain-of-function in mouse models of kidney disease stimulated cellular respiratio
Autor:
Annelise M Poss, Paul N. Hopkins, Steven C. Hunt, Mary C. Playdon, James E. Cox, J. Alan Maschek, William L. Holland, Scott A. Summers, Rebekah J. Nicholson
Publikováno v:
J Clin Endocrinol Metab
ContextGenome-wide association studies have identified associations between a common single nucleotide polymorphism (SNP; rs267738) in CERS2, a gene that encodes a (dihydro)ceramide synthase that is involved in the biosynthesis of very-long-chain sph
Publikováno v:
Mol Cell Endocrinol
Sphingolipids are essential lipid components in the intestinal epithelial cells (IEC) along the intestinal tract. They play crucial roles in maintaining barrier integrity, regulating nutrient absorption, and acting as signaling molecules to regulate
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2021)
Frontiers in Endocrinology
Frontiers in Endocrinology
Diabetic kidney disease (DKD) is a prevalent and progressive comorbidity of diabetes mellitus that increases one’s risk of developing renal failure. Progress toward development of better DKD therapeutics is limited by an incomplete understanding of