Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells

Autor: Brent D. G. Page, Nicholas C. K. Valerie, Roni H. G. Wright, Olov Wallner, Rebecka Isaksson, Megan Carter, Sean G. Rudd, Olga Loseva, Ann-Sofie Jemth, Ingrid Almlöf, Jofre Font-Mateu, Sabin Llona-Minguez, Pawel Baranczewski, Fredrik Jeppsson, Evert Homan, Helena Almqvist, Hanna Axelsson, Shruti Regmi, Anna-Lena Gustavsson, Thomas Lundbäck, Martin Scobie, Kia Strömberg, Pål Stenmark, Miguel Beato, Thomas Helleday

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)

NUDIX hydrolases are an important family of nucleotide-metabolizing enzymes. Here, the authors identify potent, small molecule inhibitors of NUDT5, which is implicated in ADP-ribose and 8-oxo-guanine metabolism, and confirm its role in gene regulatio

Externí odkaz: https://doaj.org/article/2bf99c4671d44e71969d21873ef164c4

A convenient transesterification method for synthesis of AT2 receptor ligands with improved stability in human liver microsomes

Autor: Ulf Bremberg, Rebecka Isaksson, Maria Backlund, Mats Larhed, Jonas Sävmarker, Mathias Hallberg, Johan Wannberg

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 28:519-522

A series of AT2R ligands have been synthesized applying a quick, simple, and safe transesterification-type reaction whereby the sulfonyl carbamate alkyl tail of the selective AT2R antagonist C38 was varied. Furthermore, a limited number of compounds

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61e5c239b603febdcb0fe249d23dfe08
https://doi.org/10.1016/j.bmcl.2017.11.042

Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells

Autor: Sean G. Rudd, Shruti Regmi, Roni H. G. Wright, Evert Homan, Olga Loseva, Thomas Helleday, Sabin Llona-Minguez, Olov A. Wallner, Ingrid Almlöf, Anna-Lena Gustavsson, Jofre Font-Mateu, Rebecka Isaksson, Megan Carter, Ann-Sofie Jemth, Pål Stenmark, Thomas Lundbäck, Helena Almqvist, Pawel Baranczewski, Kia Strömberg, Nicholas C.K. Valerie, Brent D. G. Page, Martin Scobie, Fredrik Jeppsson, Hanna Axelsson, Miguel Beato

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Recercat. Dipósit de la Recerca de Catalunya
instname
Nature Communications

With a diverse network of substrates, NUDIX hydrolases have emerged as a key family of nucleotide-metabolizing enzymes. NUDT5 (also called NUDIX5) has been implicated in ADP-ribose and 8-oxo-guanine metabolism and was recently identified as a rheosta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::248a82c4c016f63cf19a08615089b281
http://hdl.handle.net/20.500.12328/3012

Microwave Promoted Transcarbamylation Reaction of Sulfonylcarbamates under Continuous-Flow Conditions

Autor: Johan Wannberg, Mats Larhed, Ilze Kumpiņa, Rebecka Isaksson, Jonas Sävmarker

Successful conditions for the transcarbamylation/transesterification reaction of sulfonylcarbamates with alcohols by microwave heating under continuous-flow conditions were developed. After optimization of the processes, two series of O-alkylsulfonyl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e50615f9b606b29e4fbc1ed92e7914b3
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-282387

Contributors

Autor: Marie-Isabel Aguilar, Natalia Alenina, Peter W. Angus, Michael Bader, Ana Paula Correa Oliveira Bahia, Dhaniel Baraldi, Lívia Corrêa Barroso, Lenice Becker, Douglas M. Bennion, Serge P. Bottari, Peter Buehlmayer, Maria J. Campagnole-Santos, Robert M. Carey, Harshita Chodavarapu, Leoluca Criscione, Juraj Culman, Björn Dahlöf, Leon Alexander Danyel, Marc de Gasparo, Mark Del Borgo, Kate M. Denton, Isha S. Dhande, Gere S. diZerega, Fernando Pablo Dominici, Adelina M. dos Reis, Victor J. Dzau, Veronica Valero Esquitino, Anderson J. Ferreira, Anna Foryst-Ludwig, Sébastien Foulquier, Rodrigo A. Fraga-Silva, Frédéric Frézard, Pascal Furet, Patricia E. Gallagher, Lie Gao, Tracey A. Gaspari, Mariela M. Gironacci, Anders Hallberg, Chandana B. Herath, Lucinda M. Hilliard, Masatsugu Horiuchi, Tahir Hussain, Rebecka Isaksson, Emma S. Jones, Elena Kaschina, Michael Katovich, Ulrich Kintscher, Mats Larhed, Eric Lazartigues, Kai Y. Mak, Nephtali Marina, Claudia A. McCarthy, Adam P. Mecca, Marcos Barrouin Melo, Katrina M. Mirabito, Masaki Mogi, Angie Molina, Augusto C. Montezano, Daisy Motta-Santos, Clara Nahmias, Pawel Namsolleck, Anne Nehlig, Aurelie Nguyen, Valéria Nunes-Souza, Ludovit Paulis, Sérgio Veloso Brant Pinheiro, Luiza A. Rabelo, Mohan K. Raizada, Chiara Recarti, Robert W. Regenhardt, Fernando M. Reis, Kathleen E. Rodgers, Sylvie Rodrigues-Ferreira, Walkyria Oliveira Sampaio, Robson Augusto Souza dos Santos, Sérgio Henrique Sousa Santos, Carmine Savoia, Vinayak Shenoy, Kátia Daniella Silveira, Ana Cristina Simões Silva, Ulrike M. Steckelings, Colin Sumners, E. Ann Tallant, Mauro Martins Teixeira, Rhian M. Touyz, Anthony J. Turner, Thomas Unger, Daniel C. Villela, Antony Vinh, Massimo Volpe, Yan Wang, Iresha Welungoda, Steven Whitebread, Robert E. Widdop, Bryan Williams, Irving H. Zucker

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bab3c1c905126763c396736b38e0a246
https://doi.org/10.1016/b978-0-12-801364-9.09994-6