Výsledky vyhledávání - "Rebeccah F. Young"

Akademický článek

Brief Myocardial Ischemia Produces Cardiac Troponin I Release and Focal Myocyte Apoptosis in the Absence of Pathological Infarction in Swine

Autor: Brian R. Weil, PhD, Rebeccah F. Young, MA, Xiaomeng Shen, BS, Gen Suzuki, MD, PhD, Jun Qu, PhD, Saurabh Malhotra, MD, MPH, John M. Canty, Jr.MD

Publikováno v: JACC: Basic to Translational Science, Vol 2, Iss 2, Pp 105-114 (2017)

Summary: In a porcine model of brief ischemia leading to reversible stunning in the absence of tissue necrosis, we demonstrated delayed release of cardiac troponin I (cTnI) that exceeded the 99th percentile for normal animals 60 min after reperfusion

Externí odkaz: https://doaj.org/article/122c89020dea4813ba8d78709412c816

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Akademický článek

Heart-Derived Stem Cells in Miniature Swine with Coronary Microembolization: Novel Ischemic Cardiomyopathy Model to Assess the Efficacy of Cell-Based Therapy

Autor: Gen Suzuki, Rebeccah F. Young, Merced M. Leiker, Takayuki Suzuki

Publikováno v: Stem Cells International, Vol 2016 (2016)

A major problem in translating stem cell therapeutics is the difficulty of producing stable, long-term severe left ventricular (LV) dysfunction in a large animal model. For that purpose, extensive infarction was created in sinclair miniswine by injec

Externí odkaz: https://doaj.org/article/9cf178ae2bff44daa17baeaf5e7a3484

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Akademický článek

Autor: Brian R. Weil, PhD, Rebeccah F. Young, MA, Xiaomeng Shen, BS, Gen Suzuki, MD, PhD, Jun Qu, PhD, Saurabh Malhotra, MD, MPH, John M. Canty, Jr., MD

Publikováno v: JACC: Basic to Translational Science, Vol 2, Iss 4, p 499 (2017)

Externí odkaz: https://doaj.org/article/f2438988751c4b0bad37a8620b9f9801

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Widespread intracoronary allogeneic cardiosphere-derived cell therapy with and without cyclosporine in reperfused myocardial infarction

Autor: George Techiryan, Brian R. Weil, Rebeccah F. Young, John M. Canty

Publikováno v: American journal of physiology. Heart and circulatory physiology. 323(5)

In a three-way blinded, randomized design, we determined whether allogeneic CDCs administered at reperfusion improved myocardial function and whether intravenous cyclosporine enhanced their efficacy. In contrast to prior studies using oral cyclospori

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a82eaf866dc9a0e567cecf29ef4029d9
https://pubmed.ncbi.nlm.nih.gov/36083793

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Quantitative proteomic and phosphoproteomic profiling of ischemic myocardial stunning in swine

Autor: Rebeccah F. Young, Xue Wang, John M. Canty, Jun Qu, Xiaomeng Shen, Brian R. Weil

Publikováno v: Am J Physiol Heart Circ Physiol

Despite decades of research on the pathophysiology of myocardial stunning, protein changes and/or phosphorylation status underlying alterations in cardiac function/structure remain inadequately understood. Here, we utilized comprehensive and quantita

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a918624277081c0c42469ed20981c58a
https://doi.org/10.1152/ajpheart.00713.2019

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Nonocclusive multivessel intracoronary infusion of allogeneic cardiosphere-derived cells early after reperfusion prevents remote zone myocyte loss and improves global left ventricular function in swine with myocardial infarction

Autor: John M. Canty, Brian R. Weil, James A. Fallavollita, Rebeccah F. Young, Gen Suzuki

Publikováno v: Am J Physiol Heart Circ Physiol

Intracoronary cardiosphere-derived cells (icCDCs) infused into the infarct-related artery reduce scar volume but do not improve left ventricular (LV) ejection fraction (LVEF). We tested the hypothesis that this reflects the inability of regional deli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f461eb2de920f6d133783e93094e7cf5
https://doi.org/10.1152/ajpheart.00124.2019

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Abstract 265: Systemic Inflammation and Cardiac Macrophage Infiltration Accompany Stretch-induced Myocardial Injury in Swine Subjected to Transient Pressure Overload

Autor: Dorcas Nsumbu, Kristen Kosmerl, Shannon Allen, Rebeccah F. Young, Brian R. Weil, John M. Canty

Publikováno v: Circulation Research. 127

Objective: Transient pressure overload (TPO) elicits stretch-induced myocyte injury in the absence of ischemia or infarction, but the extent to which this is associated with inflammation is unclear. The present study was designed to assess immune act

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b2fe1df7f0f33589588bad161fd227e0
https://doi.org/10.1161/res.127.suppl_1.265

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Sensitive, High-Throughput, and Robust Trapping-Micro-LC-MS Strategy for the Quantification of Biomarkers and Antibody Biotherapeutics

Autor: Surendra Bansal, Jun Qu, Ming Zhang, Xue Wang, Keeley Murphy, Luca Ferrari, Shaolian Zhou, Yang Qu, Shichen Shen, Bo An, John M. Canty, Rebeccah F. Young, Debadeep Bhattacharyya, Jonathan L. Josephs, Yuan-Ju Chen, Wei Fu, Faye Vazvaei, Joseph P. Balthasar

Publikováno v: Analytical Chemistry. 90:1870-1880

For LC-MS-based targeted quantification of biotherapeutics and biomarkers in clinical and pharmaceutical environments, high sensitivity, high throughput, and excellent robustness are all essential but remain challenging. For example, though nano-LC-M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9be6a7821372dd2fbc8d55243a4ab824
https://doi.org/10.1021/acs.analchem.7b03949

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