Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Rebeccah F. Young"'
Publikováno v:
American journal of physiology. Heart and circulatory physiology. 323(5)
In a three-way blinded, randomized design, we determined whether allogeneic CDCs administered at reperfusion improved myocardial function and whether intravenous cyclosporine enhanced their efficacy. In contrast to prior studies using oral cyclospori
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a82eaf866dc9a0e567cecf29ef4029d9
https://pubmed.ncbi.nlm.nih.gov/36083793
https://pubmed.ncbi.nlm.nih.gov/36083793
Autor:
Brian R. Weil, PhD, Rebeccah F. Young, MA, Xiaomeng Shen, BS, Gen Suzuki, MD, PhD, Jun Qu, PhD, Saurabh Malhotra, MD, MPH, John M. Canty, Jr.MD
Publikováno v:
JACC: Basic to Translational Science, Vol 2, Iss 2, Pp 105-114 (2017)
Summary: In a porcine model of brief ischemia leading to reversible stunning in the absence of tissue necrosis, we demonstrated delayed release of cardiac troponin I (cTnI) that exceeded the 99th percentile for normal animals 60 min after reperfusion
Externí odkaz:
https://doaj.org/article/122c89020dea4813ba8d78709412c816
Publikováno v:
PLoS ONE, Vol 11, Iss 11, p e0165926 (2016)
Numerous studies have shown a beneficial effect of cardiosphere-derived cell (CDC) therapy on regeneration of injured myocardium. Paracrine signaling by CDC secreted exosomes may contribute to improved cardiac function. However, it has not yet been d
Externí odkaz:
https://doaj.org/article/6f18ed8e0402420a96916fa561675397
Publikováno v:
Stem Cells International, Vol 2016 (2016)
A major problem in translating stem cell therapeutics is the difficulty of producing stable, long-term severe left ventricular (LV) dysfunction in a large animal model. For that purpose, extensive infarction was created in sinclair miniswine by injec
Externí odkaz:
https://doaj.org/article/9cf178ae2bff44daa17baeaf5e7a3484
Publikováno v:
Am J Physiol Heart Circ Physiol
Despite decades of research on the pathophysiology of myocardial stunning, protein changes and/or phosphorylation status underlying alterations in cardiac function/structure remain inadequately understood. Here, we utilized comprehensive and quantita
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a918624277081c0c42469ed20981c58a
https://doi.org/10.1152/ajpheart.00713.2019
https://doi.org/10.1152/ajpheart.00713.2019
Publikováno v:
Am J Physiol Heart Circ Physiol
Intracoronary cardiosphere-derived cells (icCDCs) infused into the infarct-related artery reduce scar volume but do not improve left ventricular (LV) ejection fraction (LVEF). We tested the hypothesis that this reflects the inability of regional deli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f461eb2de920f6d133783e93094e7cf5
https://doi.org/10.1152/ajpheart.00124.2019
https://doi.org/10.1152/ajpheart.00124.2019
Autor:
Brian R. Weil, PhD, Rebeccah F. Young, MA, Xiaomeng Shen, BS, Gen Suzuki, MD, PhD, Jun Qu, PhD, Saurabh Malhotra, MD, MPH, John M. Canty, Jr., MD
Publikováno v:
JACC: Basic to Translational Science, Vol 2, Iss 4, p 499 (2017)
Externí odkaz:
https://doaj.org/article/f2438988751c4b0bad37a8620b9f9801
Autor:
Gen Suzuki, Brian R Weil, Merced M Leiker, Amanda E Ribbeck, Rebeccah F Young, Thomas R Cimato, John M Canty
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e113009 (2014)
Cardiosphere-derived cells (CDCs) improve ventricular function and reduce fibrotic volume when administered via an infarct-related artery using the "stop-flow" technique. Unfortunately, myocyte loss and dysfunction occur globally in many patients wit
Externí odkaz:
https://doaj.org/article/284f92a0ce214e119953e16fb3e7a9a8
Publikováno v:
The FASEB Journal. 35
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::958e155f97672ee24a2c9679d4e967eb
https://doi.org/10.1096/fasebj.2021.35.s1.01895
https://doi.org/10.1096/fasebj.2021.35.s1.01895
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e73861 (2013)
BACKGROUND: Hypercholesterolemia plays a critical role in atherosclerosis. CD34+ CD45dim Lineage- hematopoietic stem/progenitor cells (HSPCs) give rise to the inflammatory cells linked to atherosclerosis. In mice, high cholesterol levels mobilize HSP
Externí odkaz:
https://doaj.org/article/ca51ba15221d48228067d597333e4aee