Zobrazeno 1 - 10 of 12 pro vyhledávání: '"Rebecca Wyatt"'
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Akademický článek
Single-cell RNAseq identifies clonally expanded antigen-specific T-cells following intradermal injection of gold nanoparticles loaded with diabetes autoantigen in humans
Autor: Stephanie J. Hanna, Terri C. Thayer, Emma J. S. Robinson, Ngoc-Nga Vinh, Nigel Williams, Laurie G. Landry, Robert Andrews, Qi Zhuang Siah, Pia Leete, Rebecca Wyatt, Martina A. McAteer, Maki Nakayama, F. Susan Wong, Jennie H. M. Yang, Timothy I. M. Tree, Johnny Ludvigsson, Colin M. Dayan, Danijela Tatovic
Publikováno v: Frontiers in Immunology, Vol 14 (2023)
Gold nanoparticles (GNPs) have been used in the development of novel therapies as a way of delivery of both stimulatory and tolerogenic peptide cargoes. Here we report that intradermal injection of GNPs loaded with the proinsulin peptide C19-A3, in p
Externí odkaz: https://doaj.org/article/53e6f7919fde4d98856728343312e345
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5
The first 142 amino acids of glutamate decarboxylase do not contribute to epitopes recognized by autoantibodies associated with Type 1 diabetes
Autor: Peter Achenbach, Benjamin Thomas Gillard, Rebecca Wyatt, Anna E. Long, Cristina Brigatti, Lorenzo Piemonti, Deborah K. Shoemark, Ilaria Marzinotto, Kathleen M Gillespie, Kyla Chandler, Alistair J K Williams, Daniela Liberati, Vito Lampasona, Sian Grace
Publikováno v: Wyatt, R, Brigatti, C, Liberati, D, Grace, S, Gillard, B, Long, A, Marzinotto, I, Shoemark, D, Chandler, K, Achenbach, P, Gillespie, K, Piemonti, L, Lampasona, V & Williams, A 2018, ' The first 142 amino acids of glutamate decarboxylase do not contribute to epitopes recognized by autoantibodies associated with Type 1 diabetes ', Diabetic Medicine, vol. 35, no. 7, pp. 954-963 . https://doi.org/10.1111/dme.13628
Aims: Glutamate decarboxylase (GAD) antibodies are the most widely used predictive marker for Type 1 diabetes, but many individuals currently found to be GAD antibody-positive are unlikely to develop diabetes. We have shown previously that radioimmun
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e5bdd2231dc7c8fbcc2a0bbac4509d6
https://doi.org/10.1111/dme.13628
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6
A novel LIPS assay for insulin autoantibodies
Autor: Frans Gorus, Elena Bazzigaluppi, Cristina Brigatti, Vito Lampasona, Peter Achenbach, Ilaria Marzinotto, Daniela Liberati, Ilse Weets, Emanuele Bosi, Eric V. Balti, Rebecca Wyatt, Alistair J K Williams, Ben Gillard, Maurizio Ferrari, Kathleen M Gillespie, Lorenzo Piemonti
Publikováno v: Liberati, D, Wyatt, R C, Brigatti, C, Marzinotto, I, Ferrari, M, Bazzigaluppi, E, Bosi, E, Gillard, B T, Gillespie, K M, Gorus, F, Weets, I, Balti, E, Piemonti, L, Achenbach, P, Williams, A J K & Lampasona, V 2018, ' A novel LIPS assay for insulin autoantibodies ', Acta Diabetologica, vol. 55, pp. 263-270 . https://doi.org/10.1007/s00592-017-1082-y
Aims: Insulin autoantibodies (IAA) are often the first marker of autoimmunity detected in children in the preclinical phase of type 1 diabetes (T1D). Currently, the vast majority of laboratories adopt the radiobinding micro-assay (RBA) for measuring
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2908e9b9fa1bb788a48e5820860766b4
https://doi.org/10.1007/s00592-017-1082-y
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7
Reactivity to N-Terminally Truncated GAD65(96–585) Identifies GAD Autoantibodies That Are More Closely Associated With Diabetes Progression in Relatives of Patients With Type 1 Diabetes
Autor: Polly J. Bingley, Cristina Brigatti, Vito Lampasona, Alistair J K Williams, Kathleen M Gillespie, Rebecca Wyatt, Peter Achenbach
Publikováno v: Diabetes 64, 3247-3252 (2015)
GAD autoantibodies (GADAs) identify individuals at increased risk of developing type 1 diabetes, but many people currently found to be GADA positive are unlikely to progress to clinical disease. More specific GADA assays are therefore needed. Recent
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b58360d7f63d4291dbf795fc0f118c8f
https://doi.org/10.2337/db14-1694
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8
Multiple autoimmunity in children and young adults with type 1 diabetes
Autor: Aizhan Kozhakhmetova, Rebecca Wyatt, Kathleen Gillespie, Alistair Williams, Janet Wenzlau
Publikováno v: Kozhakhmetova, A, Wyatt, R, Gillespie, K, Williams, A & Wenzlau, J 2017, ' Multiple autoimmunity in children and young adults with type 1 diabetes ', 15th International Congress of Immunology of Diabetes Society 2017, San Francisco, United States, 29/01/17 .
University of Bristol-PURE
It is well established that individuals with type 1 diabetes (T1D) are at increased risk of other autoimmune diseases but the absolute risks are unclear. The aim of this study was to determine the frequency of autoantibodies to thyroid peroxidase (TP
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::1ca99b4a311ba49346f8943688fb234b
https://hdl.handle.net/1983/77c08871-20d4-4973-9718-dde8a3e86789
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9
Beta cell function and ongoing autoimmunity in long-standing, childhood onset type 1 diabetes
Autor: Rachel J Aitken, Rebecca Wyatt, Isabel V. Wilson, Polly J. Bingley, Georgina M Williams, F. Susan Wong, Alistair J K Williams, Anna E. Long, Andrew T. Hattersley, Timothy J. McDonald, Kathleen M Gillespie
Publikováno v: Diabetologia
Williams, G, Long, A, Wilson, I, Aitken, R, Wyatt, R, McDonald, T J, Wong, S, Hattersley, A T, Williams, A, Bingley, P & Gillespie, K 2016, ' Beta cell function and ongoing autoimmunity in long-standing, childhood onset type 1 diabetes. ', Diabetologia, vol. 59, no. 12, pp. 2722-2726 . https://doi.org/10.1007/s00125-016-4087-0
Aims/hypothesis This study aimed to determine the frequency\ud of residual beta cell function in individuals with long-standing\ud type 1 diabetes who were recruited at diagnosis, and relate this\ud to baseline and current islet autoantibody profile.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12ca02d0ba14012ef14c1416b2cb8354
https://orca.cardiff.ac.uk/id/eprint/96318/1/WilliamsGillespieDiabetologia2016.pdf
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10
Islet Autoantibody Analysis: Radioimmunoassays
Autor: Rebecca, Wyatt, Alistair J K, Williams
Publikováno v: Methods in molecular biology (Clifton, N.J.). 1433
Type 1 diabetes (T1D) is a chronic inflammatory disease, caused by the immune mediated destruction of insulin-producing β-cells in the islets of the pancreas (Ziegler and Nepom, Immunity 32(4):468-478, 2010). Semiquantitative assays with high specif
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::256f7b95b5216ecea568f30ad04acd73
https://pubmed.ncbi.nlm.nih.gov/26659803
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