Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Rebecca W.Y. Ko"'
Autor:
Louis-Philippe Bernier, Christopher J. Groten, Brian A. MacVicar, Jeffrey M. LeDue, Ravi L. Rungta, Sibyl Drissler, Rebecca W.Y. Ko, Lasse Dissing-Olesen
Publikováno v:
Glia. 64:2093-2103
Astrocytes display complex morphologies with an array of fine extensions extending from the soma and the primary thick processes. Until the use of genetically encoded calcium indicators (GECIs) selectively expressed in astrocytes, Ca2+ signaling was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::adb538139706477a5793a795fbfb4409
https://doi.org/10.1002/glia.23042
https://doi.org/10.1002/glia.23042
Autor:
Brent M. Witgen, Rebecca W.Y. Ko, Henning Piilgaard, Hyun B. Choi, Micael Lønstrup, Brian A. MacVicar, Claus Mathiesen, Kirsten Thomsen, Jonas C. Fordsmann, Martin Lauritzen
Publikováno v:
The Journal of Neuroscience. 33:2562-2570
Cortical spreading depression (CSD) is associated with release of arachidonic acid, impaired neurovascular coupling, and reduced cerebral blood flow (CBF), caused by cortical vasoconstriction. We tested the hypothesis that the released arachidonic ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0c936822ff82d7b27dcf88a667444c9
https://doi.org/10.1523/jneurosci.2308-12.2013
https://doi.org/10.1523/jneurosci.2308-12.2013
Autor:
Jasmin K. Hefendehl, Timothy H. Murphy, Jeffrey M. LeDue, J. Mahler, Brian A. MacVicar, Rebecca W.Y. Ko
Publikováno v:
Nature Communications
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Amyloid-β (Aβ) plaques, a hallmark of Alzheimer's disease (AD), are surrounded by regions of neuronal and glial hyperactivity. We use in vivo two-photon and wide-field imaging of the glutamate sensor iGluSnFR to determine whether pathological chang
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cee11a647550fbc387e7a2e2cebc918f
http://europepmc.org/articles/PMC5114608
http://europepmc.org/articles/PMC5114608
Autor:
Brian A. MacVicar, Rebecca W.Y. Ko
Publikováno v:
Developmental Cell. 40:327-328
Discrete calcium signals in the fine processes of astrocytes are a recent discovery and a new mystery. In a recent issue of Neuron, Agarwal et al. (2017) report that calcium efflux from mitochondria during brief openings of the mitochondrial permeabi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86d1eff158e822d510a92b64f03bc1f7
https://doi.org/10.1016/j.devcel.2017.02.013
https://doi.org/10.1016/j.devcel.2017.02.013
Autor:
Ravi L. Rungta, Paulo Jc Lin, Jay Nair, Hyun B. Choi, Pieter R. Cullis, Brian A. MacVicar, Muthiah Manoharan, Donovan M. Ashby, Rebecca W.Y. Ko
Publikováno v:
Molecular Therapy. Nucleic Acids
Manipulation of gene expression in the brain is fundamental for understanding the function of proteins involved in neuronal processes. In this article, we show a method for using small interfering RNA (siRNA) in lipid nanoparticles (LNPs) to efficien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f20c4742c0b40d7f0c052195fc3e2d48
https://doi.org/10.1038/mtna.2013.65
https://doi.org/10.1038/mtna.2013.65
Autor:
Jingfei Zhang, Lasse Dissing-Olesen, Brian A. MacVicar, Rebecca W.Y. Ko, Hyun B. Choi, Aqsa Malik
Publikováno v:
Neuron. (1):195-207
SummaryComplement receptor 3 (CR3) activation in microglia is involved in neuroinflammation-related brain disorders and pruning of neuronal synapses. Hypoxia, often observed together with neuroinflammation in brain trauma, stroke, and neurodegenerati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93ef43e38f372dc87654ef6ceeb60d75
Autor:
Mahmoud A. Pouladi, Timothy H. Murphy, Michael R. Hayden, Rona K. Graham, Jamie D. Boyd, Rochelle M. Hines, Oana Cristina Vasuta, Lynn A. Raymond, Clare M. Gladding, Alexandra M. Kaufman, Rebecca W.Y. Ko, Austen J. Milnerwood
Publikováno v:
Neuron. (3):436
SummaryN-methyl-D-aspartate receptor (NMDAR) excitotoxicity is implicated in the pathogenesis of Huntington's disease (HD), a late-onset neurodegenerative disorder. However, NMDARs are poor therapeutic targets, due to their essential physiological ro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::629cb592db9b06dd966e9c3ce7a2e915