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A synthetic glycan array containing Cryptococcus neoformans glucuronoxylomannan capsular polysaccharide fragments allows the mapping of protective epitopes

Autor: Rebecca Ulc, Conor J. Crawford, Anthony Bowen, Orla McCabe, Maggie P. Wear, Arturo Casadevall, Lorenzo Guazzelli, Stefan Oscarson, Anne J. Jedlicka

Publikováno v: Chemical Science

A convergent synthetic strategy to Cryptococcus neoformans glucuronoxylomannan (GXM) capsular polysaccharide part structures was developed based on di-, tri-, tetra-, penta- and hexasaccharide thioglycoside building blocks. The approach permitted the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28fb99b8518dd82b6440515f62d4250c
https://doi.org/10.1039/d0sc01249a

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Synthesis of a Glucuronic Acid‐Containing Thioglycoside Trisaccharide Building Block and Its Use in the Assembly of Cryptococcus Neoformans Capsular Polysaccharide Fragments†

Autor: Lorenzo Guazzelli, Rebecca Ulc, Stefan Oscarson

Publikováno v: ChemistryOpen

As part of an ongoing project aimed at identifying protective capsular polysaccharide epitopes for the development of vaccine candidates against the fungal pathogen Cryptococcus neoformans, the synthesis and glycosylation properties of a naphthalenyl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e1a59f3638f5d9cd5c76950575d0014
http://europepmc.org/articles/PMC4906494

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Synthesis of benzyl protected β-D-GlcA-(1→2)-α-d-Man thioglycoside building blocks for construction of Cryptococcus neoformans capsular polysaccharide structures

Autor: Lorenzo Guazzelli, Rebecca Ulc, Stefan Oscarson

Publikováno v: Carbohydrate research. 389

In a project targeting the synthesis of large oligosaccharide structures corresponding to the Cryptococcus neoformans GXM capsular polysaccharide, an easy access to thiodisaccharide building blocks comprising a β-linked glucuronic acid moiety and a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c59af662f0eb04458182d0b8e93e93c
https://pubmed.ncbi.nlm.nih.gov/24612865

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