Anatomical structures, cell types and biomarkers of the Human Reference Atlas

Autor: Andreas Bueckle, Rajeev Malhotra, Sarah A. Teichmann, Yongqun He, Shin Lin, Griffin M. Weber, Marc K. Halushka, Xin Sun, James C. Gee, Hrishikesh Paul, Rebecca T. Beuschel, Sanjay Jain, Maigan A. Brusko, Clive Wasserfall, David Osumi-Sutherland, Teri A. Longacre, Kristen Browne, Amy Bernard, Gloria S. Pryhuber, Yiing Lin, Avinash Boppana, Fiona Ginty, M. Todd Valerius, Jonhan Ho, Katy Börner, Marda Jorgensen, Sujin Lee, Muzlifah Haniffa, John W. Hickey, Jeremy A. Miller, Joel C. Sunshine, Andrea J. Radtke, Ellen M. Quardokus, Laura Jardine, Bruce Herr, Songlin Ding

Publikováno v: Nature Cell Biology. 23:1117-1128

The Human Reference Atlas (HRA) aims to map all of the cells of the human body to advance biomedical research and clinical practice. This Perspective presents collaborative work by members of 16 international consortia on two essential and interlinke

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b9cdb8edb28fd4306ed4770a871f7012
https://doi.org/10.1038/s41556-021-00788-6

Spatial mapping of protein composition and tissue organization: a primer for multiplexed antibody-based imaging

Autor: Rebecca T. Beuschel, Neil L. Kelleher, Andrea J. Radtke, John W. Hickey, Jeffrey M. Spraggins, Jeannie M. Camarillo, Eliza C. Small, Emma Lundberg, Sinem K. Saka, Garry P. Nolan, Julia Hatler, R. Michael Angelo, Elizabeth McDonough, Michael P. Snyder, Josh Croteau, Richard M. Caprioli, Jeremy Fisher, Anup Sood, Stephen M. Hewitt, Anne E. Wiblin, Elizabeth K. Neumann, Ronald N. Germain, Kwanghun Chung, Alexandre Albanese

Publikováno v: Nat Methods

Tissues and organs are composed of distinct cell types that must operate in concert to perform physiological functions. Efforts to create high-dimensional biomarker catalogs of these cells are largely based on transcriptomic single-cell approaches th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da5d2c2fdd5d9df1255f23657634c7e3
https://europepmc.org/articles/PMC9264278/

IBEX – A versatile multi-plex optical imaging approach for deep phenotyping and spatial analysis of cells in complex tissues

Autor: Bradley C. Lowekamp, Anita Gola, Jonathan M. Hernandez, Colin J Chu, Jeremy L. Davis, Rebecca T. Beuschel, Joshua Croteau, Rochelle M. Shih, Evelyn Kandov, Ronald N. Germain, Ziv Yaniv, Emily Speranza, Juraj Kabat, Nishant Thakur, Andrea J. Radtke, Li Yao

The diverse composition of mammalian tissues poses challenges for understanding the cell-cell interactions required for organ homeostasis and how spatial relationships are perturbed during disease. Existing methods such as single-cell genomics, lacki

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::06665875c0e5026e315e46b11972f37d
https://doi.org/10.1101/2020.11.20.390690

The IBEX Knowledge-Base: Achieving more together with open science.

Autor: Radtke AJ; Lymphocyte Biology Section and Center for Advanced Tissue Imaging, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Anidi I; Critical Care Medicine and Pulmonary Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA., Arakkal L; Lymphocyte Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Arroyo-Mejias A; Lymphocyte Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Beuschel RT; Lymphocyte Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.; Current address for Rebecca T. Beuschel: Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Börner K; Department of Intelligent Systems Engineering, Indiana University, Bloomington, IN, USA., Chu CJ; UCL Institute of Ophthalmology and NIHR Moorfields Biomedical Research Centre, London, UK., Clark B; Lymphocyte Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Clatworthy MR; Cambridge Institute for Therapeutic Immunology and Infectious Diseases, University of Cambridge Department of Medicine, Molecular Immunity Unit, Laboratory of Molecular Biology, Cambridge, UK., Colautti J; McMaster Immunology Research Centre, Schroeder Allergy and Immunology Research Institute, Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada., Croteau J; Department of Business Development, BioLegend Inc., San Diego, CA, USA., Denha S; McMaster Immunology Research Centre, Schroeder Allergy and Immunology Research Institute, Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada., Dever R; Functional Immunogenomics Unit, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA., Dutra WO; Laboratory of Cell-Cell Interactions, Department of Morphology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil., Fritzsche S; Max-Delbrueck-Center for Molecular Medicine in the Helmholtz Association (MDC), Spatial Proteomics Group, Berlin, Germany., Fullam S; Division of Rheumatology, Rush University Medical Center, Chicago, IL, USA., Gerner MY; Department of Immunology, University of Washington School of Medicine, Seattle, WA, USA., Gola A; Robin Chemers Neustein Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY, USA., Gollob KJ; Center for Research in Immuno-oncology (CRIO), Hospital Israelita Albert Einstein, Sao Paulo, SP, Brazil., Hernandez JM; Surgical Oncology Program, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Hor JL; Lymphocyte Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Ichise H; Lymphocyte Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Jing Z; Lymphocyte Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Jonigk D; Institute of Pathology, Aachen Medical University, RWTH Aachen, Aachen, Germany.; German Center for Lung Research (DZL), Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Hannover, Germany., Kandov E; Lymphocyte Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.; Current address for Evelyn Kandov: Department of Pharmacology, Vanderbilt Brain Institute, Vanderbilt Center for Addiction Research, Vanderbilt University, Nashville, TN, USA., Kastenmüller W; Würzburg Institute of Systems Immunology, Max Planck Research Group at the Julius-Maximilians-Universität Würzburg; Würzburg, Germany., Koenig JFE; McMaster Immunology Research Centre, Schroeder Allergy and Immunology Research Institute, Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada., Kothurkar A; UCL Institute of Ophthalmology and NIHR Moorfields Biomedical Research Centre, London, UK., Kreins AY; Infection Immunity and Inflammation Research and Teaching Department, University College London Great Ormond Street Institute of Child Health, London, UK.; Great Ormond Street Hospital for Children NHS Foundation Trust, Department of Immunology and Gene Therapy, London, UK., Lamborn I; Lymphocyte Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Lin Y; Surgical Oncology Program, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Luciano Pereira Morais K; Center for Research in Immuno-oncology (CRIO), Hospital Israelita Albert Einstein, Sao Paulo, SP, Brazil., Lunich A; Critical Care Medicine and Pulmonary Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA., Luz JCS; Viral Vector Laboratory, Cancer Institute of São Paulo, University of São Paulo, SP, Brazil., MacDonald RB; UCL Institute of Ophthalmology and NIHR Moorfields Biomedical Research Centre, London, UK., Makranz C; Neuro-Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Maltez VI; Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of California San Diego, La Jolla, CA, USA., Moriaty RV; Department of Cellular and Developmental Biology, Northwestern University, Chicago, IL, USA., Ocampo-Godinez JM; Infection Immunity and Inflammation Research and Teaching Department, University College London Great Ormond Street Institute of Child Health, London, UK.; Laboratorio de Bioingeniería de Tejidos, Departamento de Estudios de Posgrado e Investigación, Universidad Nacional Autónoma de México, Mexico City, Mexico.; Laboratorio de Inmunoquímica I, Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City, Mexico., Olyntho VM; McMaster Immunology Research Centre, Schroeder Allergy and Immunology Research Institute, Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada., Padhan K; Lymphocyte Biology Section and Center for Advanced Tissue Imaging, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Remmert K; Surgical Oncology Program, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Richoz N; Cambridge Institute for Therapeutic Immunology and Infectious Diseases, University of Cambridge Department of Medicine, Molecular Immunity Unit, Laboratory of Molecular Biology, Cambridge, UK., Schrom EC; Lymphocyte Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Shang W; Lymphocyte Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Shi L; Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Shih RM; Lymphocyte Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Speranza E; Florida Research and Innovation Center, Cleveland Clinic Lerner Research Institute, Port Saint Lucie, FL, USA., Stierli S; Institute of Anatomy, University of Zurich, Zurich, Switzerland., Teichmann SA; Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Puddicombe Way, Cambridge Biomedical Campus, Cambridge, UK.; Department of Medicine, University of Cambridge, Cambridge, UK., Veres TZ; Lymphocyte Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Vierhout M; McMaster Immunology Research Centre, Schroeder Allergy and Immunology Research Institute, Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada., Wachter BT; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Wade-Vallance AK; Lymphocyte Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Williams M; Critical Care Medicine and Pulmonary Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA., Zangger N; Institute of Microbiology, ETH Zurich, Zurich, Switzerland., Germain RN; Lymphocyte Biology Section and Center for Advanced Tissue Imaging, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.; Lymphocyte Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Yaniv Z; Bioinformatics and Computational Bioscience Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

Publikováno v: ArXiv [ArXiv] 2024 Jul 26. Date of Electronic Publication: 2024 Jul 26.