DNA methylation controls unmethylated transcription start sites in the genome in trans

Autor: Steffan Christiansen, Anne-Sophie Pepin, Moshe Szyf, Rudy Zhou, Lauren Schmeltzer, Sergey Dymov, Daniel M Sapozhnikov, David Cheishvili, Rebecca Stochinsky

Publikováno v: Cheishvili, D, Christiansen, S, Stochinsky, R, Pepin, A-S, Sapozhnikov, D M, Zhou, R, Schmeltzer, L, Dymov, S & Szyf, M 2017, ' DNA methylation controls unmethylated transcription start sites in the genome in trans ', Epigenomics, vol. 9, no. 5, pp. 611-633 . https://doi.org/10.2217/epi-2016-0141

Aim: DNA methylation downregulates transcription. However, a large number of genes, which are unmethylated in the promoter region, are inactive. We tested the hypothesis that these genes are regulated by DNA methylation of upstream regulators. Method

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https://pure.au.dk/portal/da/publications/dna-methylation-controls-unmethylated-transcription-start-sites-in-the-genome-in-trans(cad080b3-6a04-4557-ac17-bfebd0600a5c).html