Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Rebecca Slack-Tidwell"'
Autor:
Omar Alhalabi, Jianfeng Chen, Yuxue Zhang, Yang Lu, Qi Wang, Sumankalai Ramachandran, Rebecca Slack Tidwell, Guangchun Han, Xinmiao Yan, Jieru Meng, Ruiping Wang, Anh G. Hoang, Wei-Lien Wang, Jian Song, Lidia Lopez, Alex Andreev-Drakhlin, Arlene Siefker-Radtke, Xinqiao Zhang, William F. Benedict, Amishi Y. Shah, Jennifer Wang, Pavlos Msaouel, Miao Zhang, Charles C. Guo, Bogdan Czerniak, Carmen Behrens, Luisa Soto, Vassiliki Papadimitrakopoulou, Jeff Lewis, Waree Rinsurongkawong, Vadeerat Rinsurongkawong, Jack Lee, Jack Roth, Stephen Swisher, Ignacio Wistuba, John Heymach, Jing Wang, Matthew T. Campbell, Eleni Efstathiou, Mark Titus, Christopher J. Logothetis, Thai H. Ho, Jianjun Zhang, Linghua Wang, Jianjun Gao
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
The deficiency of MTAP, an enzyme of the adenine salvage pathway, occurs in some cancers. Here the authors perform a small cohort phase II clinical trial with metastatic MTAP-deficient urothelial cancer (UC) and show an increased overall response whe
Externí odkaz:
https://doaj.org/article/7a4eb434bab9460784c2152084c1035e
Autor:
Patrick Glen Pilié, Rebecca Slack Tidwell, Paul Vincent Viscuse, Sumit Kumar Subudhi, Paul Gettys Corn, Shi-Ming Tu, John C. Araujo, Amado J. Zurita, Jennifer Wang, Eleni Efstathiou, Jessica Deinert, Christopher Logothetis, Timothy C. Thompson, Ana Aparicio
Publikováno v:
Journal of Clinical Oncology. 41:196-196
196 Background: An aggressive subset of prostate cancers (AVPC) respond poorly to androgen signaling inhibitors, have limited therapeutic options and a dismal prognosis. Preclinical models of AVPC display functional alterations in DNA damage response
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6706fe0124e91f0ce45a4776c546450e
https://doi.org/10.1200/jco.2023.41.6_suppl.196
https://doi.org/10.1200/jco.2023.41.6_suppl.196
Autor:
Paul Vincent Viscuse, Miao Zhang, Prih Rohra, Rebecca Slack Tidwell, Colin C. Pritchard, Sumit Kumar Subudhi, Patrick Glen Pilié, Christopher Logothetis, Paul Gettys Corn, Ana Aparicio
Publikováno v:
Journal of Clinical Oncology. 41:250-250
250 Background: 20-30% of prostate cancers respond poorly to androgen receptor (AR)-directed therapies and have an atypical, virulent course. The aggressive variant prostate cancers ( AVPC) encompass virulent androgen indifferent tumors and are chara
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06e6d03dcb13ccdcd9b412a46845cbb6
https://doi.org/10.1200/jco.2023.41.6_suppl.250
https://doi.org/10.1200/jco.2023.41.6_suppl.250
Autor:
Elshad Hasanov, Lesley Flynt, Rebecca Slack Tidwell, Hyunsoo Hwang, Roserika Brooks, Lauren Michelle King, Travis Solley, Dahlia Mack, Yuko Yamamura, Colin Hayward, Aradhana M. Venkatesan, Eric Jonasch
Publikováno v:
Journal of Clinical Oncology. 41:TPS749-TPS749
TPS749 Background: Complete response (CR) is still a rare event in patients with advanced clear cell renal cell carcinoma (ccRCC). The combination of nivolumab plus cabozantinib was recently approved for the first-line treatment of ccRCC based on the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27976fd8c695b350b13d9dda22f1eb28
https://doi.org/10.1200/jco.2023.41.6_suppl.tps749
https://doi.org/10.1200/jco.2023.41.6_suppl.tps749
Autor:
Andrew Warren Hahn, Rebecca Slack Tidwell, Whittney Thoman, Amer Abdulla, Efstratios Koutroumpakis, Ana Aparicio, Sumit Kumar Subudhi, Bilal Ahmed Siddiqui, Patrick Glen Pilié, Amado J. Zurita, Paul Gettys Corn, Andrew Leonard Laccetti, Bagi RP Jana, Karen Basen-Engquist, Christopher Logothetis
Publikováno v:
Journal of Clinical Oncology. 41:TPS273-TPS273
TPS273 Background: Prostate cancer is a disease of older age, and there is significant overlap with age-related illnesses. Androgens play a critical role in prostate cancer but also have been linked to cardiovascular (CV) disease, metabolic syndrome,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3e2db46e05def9b3be6c398d019fce4
https://doi.org/10.1200/jco.2023.41.6_suppl.tps273
https://doi.org/10.1200/jco.2023.41.6_suppl.tps273
Autor:
Omar Alhalabi, Jianfeng Chen, Yuxue Zhang, Yang Lu, Qi Wang, Sumankalai Ramachandran, Rebecca Slack Tidwell, Guangchun Han, Xinmiao Yan, Jieru Meng, Ruiping Wang, Anh G. Hoang, Wei-Lien Wang, Jian Song, Lidia Lopez, Alex Andreev-Drakhlin, Arlene Siefker-Radtke, Xinqiao Zhang, William F. Benedict, Amishi Y. Shah, Jennifer Wang, Pavlos Msaouel, Miao Zhang, Charles C. Guo, Bogdan Czerniak, Carmen Behrens, Luisa Soto, Vassiliki Papadimitrakopoulou, Jeff Lewis, Waree Rinsurongkawong, Vadeerat Rinsurongkawong, Jack Lee, Jack Roth, Stephen Swisher, Ignacio Wistuba, John Heymach, Jing Wang, Matthew T. Campbell, Eleni Efstathiou, Mark Titus, Christopher J. Logothetis, Thai H. Ho, Jianjun Zhang, Linghua Wang, Jianjun Gao
Publikováno v:
Nature communications. 13(1)
Methylthioadenosine phosphorylase, an essential enzyme for the adenine salvage pathway, is often deficient (MTAPdef) in tumors with 9p21 loss and hypothetically renders tumors susceptible to synthetic lethality by antifolates targeting de novo purine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1544524fde19a062b799e2b15d8be32b
https://pubmed.ncbi.nlm.nih.gov/35379845
https://pubmed.ncbi.nlm.nih.gov/35379845
Autor:
Jianhua Zhang, Jennifer Wang, Ana Aparicio, Miao Zhang, Paul Vincent Viscuse, John C. Araujo, Eleni Efstathiou, Jingjing Liu, Shi-Ming Tu, Rebecca Slack Tidwell, Sumit K. Subudhi, Amado J. Zurita, Paul G. Corn, Patricia Troncoso, Patrick G. Pilie, Jianbo Wang, Christopher J. Logothetis
Publikováno v:
Journal of Clinical Oncology. 38:156-156
156 Background: AVPC are morphologically heterogeneous tumors that share clinical features with the rare, virulent, androgen-indifferent and platinum-sensitive, small cell histologic variant. The AVPC-ms is composed of ≥2 defects in TP53, RB1 and P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c66f3bd57f3fe2d0fbc298966e16391e
https://doi.org/10.1200/jco.2020.38.6_suppl.156
https://doi.org/10.1200/jco.2020.38.6_suppl.156
Autor:
Jianjun Gao, Jose A. Karam, Nizar M. Tannir, Matthew T Campbell, Rebecca Slack Tidwell, Kamran Ahrar, Priya Rao, Chaan S. Ng, Eric Jonasch, Surena F. Matin, Amado J. Zurita, Amishi Yogesh Shah, Yu Shen, Jorge M. Blando, Luis M. Vence, Sreyashi Basu, Hao Zhao, James Patrick Allison, Christopher G. Wood, Padmanee Sharma
Publikováno v:
Journal of Clinical Oncology. 37:4501-4501
4501 Background: Cytoreductive surgery (CS) including cytoreductive nephrectomy and metastasectomy provides clinical benefits to patients with MRCC. However, CS has not been evaluated in the setting of immune checkpoint (IC) therapy. We performed a p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95a896147b6acab1062de93cfa3d30bc
https://doi.org/10.1200/jco.2019.37.15_suppl.4501
https://doi.org/10.1200/jco.2019.37.15_suppl.4501
Autor:
Ashley H. Woodson, Jennifer M Hoskovec, Eric Jonasch, Annelise Pace, Molly S. Daniels, Jennifer K. Litton, Patrick G. Pilie, Rebecca Slack-Tidwell
Publikováno v:
Journal of Clinical Oncology. 37:668-668
668 Background: Several known hereditary cancer syndromes confer an increased risk for genitourinary (GU)-related malignancies. Various guidelines indicate when to refer patients to genetic counseling for GU cancers, but there are limited data on the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::02d5ca853833f2596a8e6eb378a70e2a
https://doi.org/10.1200/jco.2019.37.7_suppl.668
https://doi.org/10.1200/jco.2019.37.7_suppl.668
Autor:
Jianjun Gao, Rebecca Slack-Tidwell, Mark Titus, Bogdan Czerniak, Arlene O. Siefker-Radtke, Wei-Lien Wang, Matthew T. Campbell, Eleni Efstathiou, Miao Zhang, Christopher J. Logothetis, Charles C. Guo, Amishi Yogesh Shah, Omar Alhalabi
Publikováno v:
Journal of Clinical Oncology. 37:385-385
385 Background: According to The Cancer Genome Atlas, 26.8% of bladder tumors harbor homozygous deletion of the MTAP gene, which encodes for an essential enzyme for the salvage pathway of nucleotide synthesis. Pemetrexed is a well-known anti-folate a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::322c5a1b32ee2ce5b06c1584b59f1775
https://doi.org/10.1200/jco.2019.37.7_suppl.385
https://doi.org/10.1200/jco.2019.37.7_suppl.385