Sustained Activation of AMPK Enhances Differentiation of Human iPSC-Derived Cardiomyocytes via Sirtuin Activation

Autor: Guido Krähenbühl, Mohsen Sarikhani, Aishah Ahmed, Jeffrey Conde, Sai Ma, Gabriela O. Escalante, Richard T. Lee, Jason D. Buenrostro, Rebecca Sereda, Jessica C. Garbern

Publikováno v: Stem Cell Reports

Summary Recent studies suggest that metabolic regulation may improve differentiation of cardiomyocytes derived from induced pluripotent stem cells (iPSCs). AMP-activated protein kinase (AMPK) is a master regulator of metabolic activities. We investig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d3f28da6a32db97e64f15eaa2a13734
https://doi.org/10.1016/j.stemcr.2020.06.012

The lysosomal proteome of senescent cells contributes to the senescence secretome

Autor: Miguel Rovira, Rebecca Sereda, David Pladevall‐Morera, Valentina Ramponi, Ines Marin, Mate Maus, Julio Madrigal‐Matute, Antonio Díaz, Fernando García, Javier Muñoz, Ana María Cuervo, Manuel Serrano

Publikováno v: Dipòsit Digital de la UB
Universidad de Barcelona
Rovira, M, Sereda, R, Pladevall-Morera, D, Ramponi, V, Marin, I, Maus, M, Madrigal-Matute, J, Díaz, A, García, F, Muñoz, J, Cuervo, A M & Serrano, M 2022, ' The lysosomal proteome of senescent cells contributes to the senescence secretome ', Aging Cell, vol. 21, no. 10, e13707 . https://doi.org/10.1111/acel.13707

Senescent cells accumulate in tissues over time, favoring the onset and progression of multiple age-related diseases. Senescent cells present a remarkable increase in lysosomal mass and elevated autophagic activity. Here, we report that two main auto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5db764bd6346a8243bac630352951165
http://hdl.handle.net/2445/189124

Analysis of Cre-mediated genetic deletion of

Autor: Jessica, Garbern, Amy C, Kristl, Vinicius, Bassaneze, Ana, Vujic, Henk, Schoemaker, Rebecca, Sereda, Liming, Peng, Elisabeth M, Ricci-Blair, Jill M, Goldstein, Ryan G, Walker, Shalender, Bhasin, Amy J, Wagers, Richard T, Lee

Publikováno v: Am J Physiol Heart Circ Physiol

Administration of active growth differentiation factor 11 (GDF11) to aged mice can reduce cardiac hypertrophy, and low serum levels of GDF11 measured together with the related protein, myostatin (also known as GDF8), predict future morbidity and mort

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fa8afded420d4d4e103ccafdbfe04cec
https://pubmed.ncbi.nlm.nih.gov/31125255