Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Rebecca S. Silkstone"'
Autor:
Rebecca S. Silkstone, Gary Silkstone, Kristian Kallberg, Leif Bülow, Khuanpiroon Ratanasopa, Michael T. Wilson, Brandon J. Reeder, Chris E. Cooper, Michelle Simons, Andrea Mozzarelli, Luca Ronda
Publikováno v:
Biochemical Journal
Hemoglobin (Hb)-based oxygen carriers (HBOC) have been engineered to replace or augment the oxygen-carrying capacity of erythrocytes. However, clinical results have generally been disappointing due to adverse side effects linked to intrinsic heme-med
Autor:
Badri S. Rajagopal, Leif Bülow, Rebecca S. Silkstone, Gary Silkstone, Brandon J. Reeder, Luca Ronda, Peter Nicholls, J A Baath, Chris E. Cooper
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9781493930227
It has been proposed that introducing tyrosine residues into human hemoglobin (e.g. βPhe41Tyr) may be able to reduce the toxicity of the ferryl heme species in extracellular hemoglobin-based oxygen carriers (HBOC) by facilitating long-range electron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf9aa866c131166dd576c5bb582429ad
https://doi.org/10.1007/978-1-4939-3023-4_57
https://doi.org/10.1007/978-1-4939-3023-4_57
Publikováno v:
Free Radical Biology & Medicine
We previously reported that high micromolar concentrations of nitric oxide were able to oxidize mitochondrial cytochrome c at physiological pH, producing nitroxyl anion (Sharpe and Cooper, 1998 Biochem. J. 332, 9–19). However, the subsequent re-eva