Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Rebecca S. Muraoka-Cook"'
Autor:
Kiran Mahajan, Domenico Coppola, Sridevi Challa, Bin Fang, Y Ann Chen, Weiwei Zhu, Alexis S Lopez, John Koomen, Robert W Engelman, Charlene Rivera, Rebecca S Muraoka-Cook, Jin Q Cheng, Ernst Schönbrunn, Said M Sebti, H Shelton Earp, Nupam P Mahajan
Publikováno v:
PLoS ONE, Vol 5, Iss 3, p e9646 (2010)
The AKT/PKB kinase is a key signaling component of one of the most frequently activated pathways in cancer and is a major target of cancer drug development. Most studies have focused on its activation by Receptor Tyrosine Kinase (RTK) mediated Phosph
Externí odkaz:
https://doaj.org/article/7f2b87878a874c4898e87e6d35f2af22
Autor:
Lu Xie, David B. Vaught, Sam Wells, Dana M. Brantley-Sieders, Jian Yu, Guanglei Zhuang, Jin Chen, Rebecca S. Muraoka-Cook, Carlos L. Arteaga, Dowdy Jackson
Publikováno v:
Cancer Research. 70:299-308
One arising challenge in the treatment of breast cancer is the development of therapeutic resistance to trastuzumab, an antibody targeting the human epidermal growth factor receptor-2 (HER2), which is frequently amplified in breast cancers. In this s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10a152eafb1c6e0eabd844fdb929f17d
https://doi.org/10.1158/0008-5472.can-09-1845
https://doi.org/10.1158/0008-5472.can-09-1845
Publikováno v:
Molecular Endocrinology. 22:2307-2321
Differentiation of mammary epithelium in vivo requires signaling through prolactin and ErbB4/HER4-dependent mechanisms. Although stimulation of either the prolactin receptor or ErbB4/HER4 results in activation of the transcription factor signal trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::186166dcda2ecadc730b115c1e80e686
https://doi.org/10.1210/me.2008-0055
https://doi.org/10.1210/me.2008-0055
Publikováno v:
Journal of Mammary Gland Biology and Neoplasia. 13:235-246
The ErbB receptor tyrosine kinase family has often been associated with increased growth of breast epithelial cells, as well as malignant transformation and progression. In contrast, ErbB4/HER4 exhibits unique attributes from a two step proteolytic c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aa8806691801fb3f1a04d647b04a88e
https://doi.org/10.1007/s10911-008-9080-x
https://doi.org/10.1007/s10911-008-9080-x
Autor:
Yoonha Hwang, Elizabeth Bruckheimer, Jin Chen, Justin M M Cates, Dana M. Brantley-Sieders, Wei Bin Fang, Karen Coffman, Dowdy Jackson, Donna J. Hicks, Rebecca S. Muraoka-Cook, Guanglei Zhuang
Publikováno v:
Journal of Clinical Investigation. 118:64-78
Overexpression of the receptor tyrosine kinase EPH receptor A2 (EphA2) is commonly observed in aggressive breast cancer and correlates with a poor prognosis. However, while EphA2 has been reported to enhance tumorigenesis, proliferation, and MAPK act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35cb4567ae54ad4d33e22533cfc35991
https://doi.org/10.1172/jci33154
https://doi.org/10.1172/jci33154
Autor:
Hong Zhou, Shu Mang Feng, Ruth Chen Dy, Laura S. Caskey, Debra Hunter, Xihui Yang, H. Shelton Earp, Rebecca S. Muraoka-Cook, Carolyn I. Sartor
Publikováno v:
Molecular Endocrinology. 21:1861-1876
Unlike the proliferative action of other epidermal growth factor (EGF) receptor family members, HER4/ErbB4 is often associated with growth-inhibitory and differentiation signaling. These actions may involve HER4 two-step proteolytic processing by int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc0c8059122b724316ae3c6ade300ed1
https://doi.org/10.1210/me.2006-0101
https://doi.org/10.1210/me.2006-0101
Publikováno v:
Clinical Cancer Research. 11:937s-943s
It is generally accepted that transforming growth factor β (TGFβ) is both a tumor suppressor and tumor promoter. Whereas loss or attenuation of TGFβ signal transduction is permissive for transformation, introduction of dominant-negative TGFβ rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::528449a2dfa0a162bf4fecf08b3d770b
https://doi.org/10.1158/1078-0432.937s.11.2
https://doi.org/10.1158/1078-0432.937s.11.2
Autor:
Charlene Rivera, Kiran Mahajan, Alexis S. Lopez, John M. Koomen, Rebecca S. Muraoka-Cook, H. Shelton Earp, Domenico Coppola, Nupam P. Mahajan, Said M. Sebti, Sridevi Challa, Y. Ann Chen, Weiwei Zhu, Ernst Schönbrunn, Bin Fang, Robert W. Engelman, Jin Q. Cheng
Publikováno v:
PLoS ONE
PLoS ONE, Vol 5, Iss 3, p e9646 (2010)
PLoS ONE, Vol 5, Iss 3, p e9646 (2010)
The AKT/PKB kinase is a key signaling component of one of the most frequently activated pathways in cancer and is a major target of cancer drug development. Most studies have focused on its activation by Receptor Tyrosine Kinase (RTK) mediated Phosph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c749265ca1a3e799a544fc9d40753bc9
http://europepmc.org/articles/PMC2841635
http://europepmc.org/articles/PMC2841635
Autor:
Karen E. Strunk, Carty Husted, Melissa Sandahl, Rebecca S. Muraoka-Cook, Leah C. Miraglia, Debra Hunter, H. Shelton Earp, Lewis A. Chodosh, Klaus Elenius
Publikováno v:
Molecular and cellular biology. 29(18)
Data concerning the prognostic value of ErbB4 in breast cancer and effects on cell growth have varied in published reports, perhaps due to the unknown signaling consequences of expression of the intracellular proteolytic ErbB4 s80(HER4) fragment or d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c312cb072e941d9856971f2e2fc51c39
https://pubmed.ncbi.nlm.nih.gov/19596786
https://pubmed.ncbi.nlm.nih.gov/19596786
Autor:
Rebecca S. Muraoka-Cook, Azeddine Atfi, Melissa Sandahl, Debra Hunter, H. Shelton Earp, Shu Mang Feng, Laura S. Caskey, Keiji Miyazawa
In general, epidermal growth factor receptor family members stimulate cell proliferation. In contrast, at least one HER4 isoform, JM-a/Cyt1, inhibits cell growth after undergoing a two-step proteolytic cleavage that first produces a membrane-anchored
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36b5b9d5d9cb459862a44ba21851b832
https://europepmc.org/articles/PMC2630679/
https://europepmc.org/articles/PMC2630679/
