Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Rebecca S. Goydel"'
Adoptive T cell immunotherapy for medullary thyroid carcinoma targeting GDNF family receptor alpha 4
Autor:
Vijay G. Bhoj, Lucy Li, Kalpana Parvathaneni, Zheng Zhang, Stephen Kacir, Dimitrios Arhontoulis, Kenneth Zhou, Bevin McGettigan-Croce, Selene Nunez-Cruz, Gayathri Gulendran, Alina C. Boesteanu, Laura Johnson, Michael D. Feldman, Enrico Radaelli, Keith Mansfield, MacLean Nasrallah, Rebecca S. Goydel, Haiyong Peng, Christoph Rader, Michael C. Milone, Don L. Siegel
Publikováno v:
Molecular Therapy: Oncolytics, Vol 20, Iss , Pp 387-398 (2021)
Metastatic medullary thyroid cancer (MTC) is a rare but often aggressive thyroid malignancy with a 5-year survival rate of less than 40% and few effective therapeutic options. Adoptive T cell immunotherapy using chimeric antigen receptor (CAR)-modifi
Externí odkaz:
https://doaj.org/article/21295495ac0b4d158ff8bf09829bb9f3
Autor:
Alex R. Nanna, Xiuling Li, Even Walseng, Lee Pedzisa, Rebecca S. Goydel, David Hymel, Terrence R. Burke Jr., William R. Roush, Christoph Rader
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
Current strategies for producing antibody-drug conjugates often rely on inefficient conjugation chemistry or on generating mutations in the antibody sequence. Here the authors demonstrate a mutation-free, single-step conjugation platform utilizing a
Externí odkaz:
https://doaj.org/article/327d54533f8140538f895070e14be5c5
Adoptive T cell immunotherapy for medullary thyroid carcinoma targeting GDNF family receptor alpha 4
Autor:
Selene Nunez-Cruz, Michael Feldman, Kenneth Zhou, Christoph Rader, Haiyong Peng, Stephen Kacir, Keith Mansfield, Alina C. Boesteanu, Zheng Zhang, Enrico Radaelli, MacLean Nasrallah, Bevin McGettigan-Croce, Rebecca S. Goydel, Vijay Bhoj, Don L. Siegel, Michael C. Milone, Kalpana Parvathaneni, Gayathri Gulendran, Dimitrios Arhontoulis, Lucy Z. Li, Laura A. Johnson
Publikováno v:
Molecular Therapy Oncolytics
Molecular Therapy: Oncolytics, Vol 20, Iss, Pp 387-398 (2021)
Molecular Therapy: Oncolytics, Vol 20, Iss, Pp 387-398 (2021)
Metastatic medullary thyroid cancer (MTC) is a rare but often aggressive thyroid malignancy with a 5-year survival rate of less than 40% and few effective therapeutic options. Adoptive T cell immunotherapy using chimeric antigen receptor (CAR)-modifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::136615ee16ed55eb834ffa1e9b74f952
https://pubmed.ncbi.nlm.nih.gov/33614919
https://pubmed.ncbi.nlm.nih.gov/33614919
Autor:
Junpeng Qi, Rebecca S. Goydel, Christoph Rader, Jim Freeth, Haiyong Peng, HaJeung Park, Justus Weber, Jo Soden
Publikováno v:
J Biol Chem
Antibodies are widely used as cancer therapeutics, but their current use is limited by the low number of antigens restricted to cancer cells. A receptor tyrosine kinase, receptor tyrosine kinase-like orphan receptor 2 (ROR2), is normally expressed on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaf80946ccb455795120b12d73372b9b
https://europepmc.org/articles/PMC7196640/
https://europepmc.org/articles/PMC7196640/
Autor:
William R. Roush, David Hymel, Lee Pedzisa, Even Walseng, Terrence R. Burke, Rebecca S. Goydel, Xiuling Li, Alex R. Nanna, Christoph Rader
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
Current strategies to produce homogeneous antibody-drug conjugates (ADCs) rely on mutations or inefficient conjugation chemistries. Here we present a strategy to produce site-specific ADCs using a highly reactive natural buried lysine embedded in a d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d851481143fa7fd657df9b2889b1d9c
http://europepmc.org/articles/PMC5653646
http://europepmc.org/articles/PMC5653646