Zobrazeno 1 - 10
of 224
pro vyhledávání: '"Rebecca S Cook"'
Autor:
Meghan M Morrison, Christian D Young, Shan Wang, Tammy Sobolik, Violeta M Sanchez, Donna J Hicks, Rebecca S Cook, Dana M Brantley-Sieders
Publikováno v:
PLoS Genetics, Vol 11, Iss 7, p e1005291 (2015)
Akt phosphorylation is a major driver of cell survival, motility, and proliferation in development and disease, causing increased interest in upstream regulators of Akt like mTOR complex 2 (mTORC2). We used genetic disruption of Rictor to impair mTOR
Externí odkaz:
https://doaj.org/article/5f213725e78f4caa83a26de4ea6cc6bf
Autor:
Ella N. Hoogenboezem, Shrusti S. Patel, Justin H. Lo, Ashley B. Cavnar, Lauren M. Babb, Nora Francini, Eva F. Gbur, Prarthana Patil, Juan M. Colazo, Danielle L. Michell, Violeta M. Sanchez, Joshua T. McCune, Jinqi Ma, Carlisle R. DeJulius, Linus H. Lee, Jonah C. Rosch, Ryan M. Allen, Larry D. Stokes, Jordan L. Hill, Kasey C. Vickers, Rebecca S. Cook, Craig L. Duvall
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract The high potential of siRNAs to silence oncogenic drivers remains largely untapped due to the challenges of tumor cell delivery. Here, divalent lipid-conjugated siRNAs are optimized for in situ binding to albumin to improve pharmacokinetics
Externí odkaz:
https://doaj.org/article/a8ad79f8d57c45aeac75fe1a848bd947
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e45238 (2012)
Despite available demographic data on the factors that contribute to breast cancer mortality in large population datasets, local patterns are often overlooked. Such local information could provide a valuable metric by which regional community health
Externí odkaz:
https://doaj.org/article/320476dd987f43d48bfd55e7fb256cf5
Autor:
Ann Hanna, Mellissa J. Nixon, M. Valeria Estrada, Violeta Sanchez, Quanhu Sheng, Susan R. Opalenik, Abigail L. Toren, Joshua Bauer, Phillip Owens, Frank M. Mason, Rebecca S. Cook, Melinda E. Sanders, Carlos L. Arteaga, Justin M. Balko
Publikováno v:
Breast Cancer Research, Vol 24, Iss 1, Pp 1-16 (2022)
Abstract Aim Deregulated signaling pathways are a hallmark feature of oncogenesis and driver of tumor progression. Dual specificity protein phosphatase 4 (DUSP4) is a critical negative regulator of the mitogen-activated protein kinase (MAPK) pathway
Externí odkaz:
https://doaj.org/article/6aa7b57ed41b4bac96b6712182f77f69
Autor:
J. William Tierney, Brian C. Evans, Joyce Cheung-Flynn, Bo Wang, Juan M. Colazo, Monica E. Polcz, Rebecca S. Cook, Colleen M. Brophy, Craig L. Duvall
Publikováno v:
JCI Insight, Vol 6, Iss 19 (2021)
Vascular procedures, such as stenting, angioplasty, and bypass grafting, often fail due to intimal hyperplasia (IH), wherein contractile vascular smooth muscle cells (VSMCs) dedifferentiate to synthetic VSMCs, which are highly proliferative, migrator
Externí odkaz:
https://doaj.org/article/342ff646c4854f9ab16bc9c7e294d943
Autor:
Gabriela L. Santos Guasch, J Scott Beeler, Clayton B. Marshall, Timothy M. Shaver, Quanhu Sheng, Kimberly N. Johnson, Kelli L. Boyd, Bryan J. Venters, Rebecca S. Cook, Jennifer A. Pietenpol
Publikováno v:
iScience, Vol 8, Iss , Pp 236-249 (2018)
Summary: We report that p73 is expressed in ovarian granulosa cells and that loss of p73 leads to attenuated follicle development, ovulation, and corpus luteum formation, resulting in decreased levels of circulating progesterone and defects in mammar
Externí odkaz:
https://doaj.org/article/79bbd3f5a5444de6bcdc0ceb0648766e
Autor:
Michelle M. Williams, David B. Vaught, Meghan Morrison Joly, Donna J. Hicks, Violeta Sanchez, Philip Owens, Bushra Rahman, David L. Elion, Justin M. Balko, Rebecca S. Cook
Publikováno v:
Breast Cancer Research, Vol 19, Iss 1, Pp 1-14 (2017)
Abstract Background During pregnancy, as the mammary gland prepares for synthesis and delivery of milk to newborns, a luminal mammary epithelial cell (MEC) subpopulation proliferates rapidly in response to systemic hormonal cues that activate STAT5A.
Externí odkaz:
https://doaj.org/article/52b99fc4988f4463a8d1cbe4035ebc1c
Autor:
Meghan Morrison Joly, Michelle M. Williams, Donna J. Hicks, Bayley Jones, Violeta Sanchez, Christian D. Young, Dos D. Sarbassov, William J. Muller, Dana Brantley-Sieders, Rebecca S. Cook
Publikováno v:
Breast Cancer Research, Vol 19, Iss 1, Pp 1-15 (2017)
Abstract Background The importance of the mTOR complex 2 (mTORC2) signaling complex in tumor progression is becoming increasingly recognized. HER2-amplified breast cancers use Rictor/mTORC2 signaling to drive tumor formation, tumor cell survival and
Externí odkaz:
https://doaj.org/article/398ec463dfb44d96a8fde76022898ffd
Autor:
Rebecca S. Cook, Monica Valeria Estrada, Thomas Stricker, Justin M. Balko, Violeta Sanchez, Courtney McKernan, Bushra Rahman, David Elion, Meghan M. Joly, Donna J. Hicks, Linus Lee, Michelle M. Williams
S3. Representative images of cells grown in 3D Matrigel for 14D and treated with ABT-263 (1.0 uM). S4. Whole cell lysates from cells treated with ABT-263 (1.0uM) for 0=24 hours.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3aec745cb2b74a6364d33ada1b1c7abf
https://doi.org/10.1158/1541-7786.22511347.v1
https://doi.org/10.1158/1541-7786.22511347.v1
Autor:
Rebecca S. Cook, Monica Valeria Estrada, Thomas Stricker, Justin M. Balko, Violeta Sanchez, Courtney McKernan, Bushra Rahman, David Elion, Meghan M. Joly, Donna J. Hicks, Linus Lee, Michelle M. Williams
An estimated 40,000 deaths will be attributed to breast cancer in 2016, underscoring the need for improved therapies. Evading cell death is a major hallmark of cancer, driving tumor progression and therapeutic resistance. To evade apoptosis, cancers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::076b9d2db0653b9d4cc0b45ec8c4205e
https://doi.org/10.1158/1541-7786.c.6539923.v1
https://doi.org/10.1158/1541-7786.c.6539923.v1