Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Rebecca Roddan"'
C-1 Substituted isoquinolines potentiate the antimycobacterial activity of rifampicin and ethambutol
Autor:
Liam T. Martin, Eleanor D. Lamming, Arundhati Maitra, Parisa N. Mortazavi, Rebecca Roddan, John M. Ward, Sanjib Bhakta, Helen C. Hailes
Publikováno v:
Frontiers in Antibiotics, Vol 2 (2023)
IntroductionThe emergence of extensively drug-resistant strains of Mycobacterium tuberculosis threatens decades of progress in the treatment of a disease which remains one of the leading infectious causes of death worldwide. The development of novel
Externí odkaz:
https://doaj.org/article/b19c3d06f60449e4b8617a588c56b3ec
Autor:
Max Cárdenas-Fernández, Jutta Siegrist, Fabiana Subrizi, Jennifer N. Andexer, Rebecca Roddan, Yu Wang, Daniel Méndez-Sánchez, Helen C. Hailes, John M. Ward, Benjamin Thair, Michael Richter
Publikováno v:
Angewandte Chemie (International Ed. in English)
The tetrahydroisoquinoline (THIQ) ring system is present in a large variety of structurally diverse natural products exhibiting a wide range of biological activities. Routes to mimic the biosynthetic pathways to such alkaloids, by building cascade re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5606bb0f767d452b26da3825034360c0
https://doi.org/10.1002/ange.202104476
https://doi.org/10.1002/ange.202104476
Publikováno v:
ACS Catalysis. 11:131-138
The Pictet–Spenglerase norcoclaurine synthase (NCS) catalyzes the formation of (S)-norcoclaurine, an important intermediate in the biosynthetic pathway of benzylisoquinoline alkaloids. NCS has been used as a biocatalyst with meta-hydroxy phenethyla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::738429262b743c5daa9290983a21dfe7
https://doi.org/10.1021/acscatal.0c04704
https://doi.org/10.1021/acscatal.0c04704
Publikováno v:
Natural product reports. 39(7)
Covering: 2003 up to the end of 2021Complex molecules produced by plants have provided us with a range of medicines, flavour and fragrance compounds and pesticides. However, there are challenges associated with accessing these in an economically viab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5278421b524032bbf18e57c6b63b125d
https://pubmed.ncbi.nlm.nih.gov/35343542
https://pubmed.ncbi.nlm.nih.gov/35343542
Publikováno v:
Current Opinion in Chemical Biology. 55:69-76
Pictet-Spenglerases provide a key role in the biosynthesis of many biologically active alkaloids. There is increasing use of these biocatalysts as an alternative to traditional organic synthetic methods as they provide stereoselective and regioselect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaa3d237a3a079890b33fe445de817ff
https://doi.org/10.1016/j.cbpa.2019.12.003
https://doi.org/10.1016/j.cbpa.2019.12.003
Autor:
Daniel Méndez-Sánchez, Nicholas H. Keep, Helen C. Hailes, Jürgen Pleiss, Altin Sula, Rebecca Roddan, John M. Ward, Gudrun Gygli
Publikováno v:
ACS Catalysis. 9:9640-9649
Norcoclaurine synthase (NCS) catalyzes a stereoselective Pictet–Spengler reaction to give the key intermediate, (S)-norcoclaurine in benzylisoquinoline alkaloid biosynthesis. This family of alkaloi...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d86aa4d8110e4c75ebc28b889c2e1a1b
https://doi.org/10.1021/acscatal.9b02699
https://doi.org/10.1021/acscatal.9b02699
Autor:
Altin Sula, Rebecca Roddan, Daniel Méndez-Sánchez, Michael Richter, Jennifer N. Andexer, Helen C. Hailes, Benjamin R. Lichman, John M. Ward, Joseph Broomfield, Nicholas H. Keep, Fabiana Subrizi
Publikováno v:
Communications Chemistry, Vol 3, Iss 1, Pp 1-10 (2020)
The 1-aryl-tetrahydroisoquinoline (1-aryl-THIQ) moiety is found in many biologically active molecules. Single enantiomer chemical syntheses are challenging and although some biocatalytic routes have been reported, the substrate scope is limited to ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::631690d80720d31f547bb113c6ebc93e
https://doi.org/10.1038/s42004-020-00416-8
https://doi.org/10.1038/s42004-020-00416-8