Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Rebecca Rico-Hesse"'
Autor:
Jennifer L Spencer Clinton, Megan B Vogt, Alexander R Kneubehl, Brianne M Hibl, Silke Paust, Rebecca Rico-Hesse
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 17, Iss 2, p e0011095 (2023)
Mosquito saliva is a mix of numerous proteins that are injected into the skin while the mosquito searches for a blood meal. While mosquito saliva is known to be immunogenic, the salivary components driving these immune responses, as well as the types
Externí odkaz:
https://doaj.org/article/ab9a9cea4a6e431aaef0034f3ce70505
Autor:
Jennifer L Spencer Clinton, Linda L Tran, Megan B Vogt, David R Rowley, Jason T Kimata, Rebecca Rico-Hesse
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0244587 (2020)
Our previous studies have shown that Zika virus (ZIKV) replicates in human prostate cells, suggesting that the prostate may serve as a long-term reservoir for virus transmission. Here, we demonstrated that the innate immune responses generated to thr
Externí odkaz:
https://doaj.org/article/8d1f229ebf9a4fd8a652e2b52dc839d4
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 13, Iss 11, p e0007837 (2019)
One of the most important clinical signs of dengue virus infection is the reduction of white blood cells and platelets in human peripheral blood (leukopenia and thrombocytopenia, respectively), which may significantly impair the clearance of dengue v
Externí odkaz:
https://doaj.org/article/b582e45b8633485284f50c2802fab1b9
Autor:
Megan B Vogt, Anismrita Lahon, Ravi P Arya, Alexander R Kneubehl, Jennifer L Spencer Clinton, Silke Paust, Rebecca Rico-Hesse
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 12, Iss 5, p e0006439 (2018)
Mosquito saliva is a very complex concoction of >100 proteins, many of which have unknown functions. The effects of mosquito saliva proteins injected into our skin during blood feeding have been studied mainly in mouse models of injection or biting,
Externí odkaz:
https://doaj.org/article/d59a3b18605a49dda63243f94d4badb5
Autor:
Shenyou Nie, Yuan Yao, Megan B. Vogt, Jingyu Wu, Yuanda Hua, Josephine C. Ferreon, Rebecca Rico-Hesse, Jidong Zhao, Tong Huo, Yi-Lun Lin, Fangrui Wu, Alexander R. Kneubehl, Xiaowei Wu, Yongcheng Song
Publikováno v:
J Med Chem
Flaviviruses, including Zika, dengue, and West Nile viruses, are important human pathogens. The highly conserved NS2B-NS3 protease of Flavivirus is essential for viral replication and therefore a promising drug target. Through compound screening, fol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee24b4b76624739bf8a11622a88f2e30
https://doi.org/10.1021/acs.jmedchem.0c02070
https://doi.org/10.1021/acs.jmedchem.0c02070
Autor:
Anismrita Lahon, Ravi P Arya, Alexander R Kneubehl, Megan B Vogt, Natalie J M Dailey Garnes, Rebecca Rico-Hesse
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 10, Iss 9, p e0005019 (2016)
Zika virus (Flavivirus genus) is the first mosquito-borne virus known to cause high rates of microcephaly and abortion in humans. Typically, Zika virus causes a self-limiting, systemic illness; however, the current outbreak of Zika virus in the Ameri
Externí odkaz:
https://doaj.org/article/b299a55177e7479ba4bcbc2a08f21e98
Autor:
Yongcheng Song, Alexander R. Kneubehl, Yi-Lun Lin, Shenyou Nie, Jingyu Wu, Yuan Yao, Tong Huo, Fangrui Wu, Yuanda Hua, Rebecca Rico-Hesse, Megan B. Vogt
Publikováno v:
J Am Chem Soc
Flaviviruses, including dengue, West Nile and recently emerged Zika virus, are important human pathogens, but there are no drugs to prevent or treat these viral infections. The highly conserved Flavivirus NS2B-NS3 protease is essential for viral repl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb99d983812008f0148d715c6fcfc707
https://doi.org/10.1021/jacs.9b02505
https://doi.org/10.1021/jacs.9b02505
Autor:
Xiaowei Wu, Yi-Lun Lin, Fangrui Wu, Yongcheng Song, Rebecca Rico-Hesse, Jidong Zhao, Megan B. Vogt, Shenyou Nie, Yuan Yao, Xin Li, Alexander R. Kneubehl
Publikováno v:
Eur J Med Chem
Zika virus belongs to the Flavivirus family of RNA viruses, which include other important human pathogens such as dengue and West Nile virus. There are no approved antiviral drugs for these viruses. The highly conserved NS2B-NS3 protease of Flaviviru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05e6d902f12437353924ff8a4257d3de
https://doi.org/10.1016/j.ejmech.2021.113767
https://doi.org/10.1016/j.ejmech.2021.113767
Autor:
Megan B. Vogt, Natalie J. M. Dailey Garnes, Alexander R. Kneubehl, Brianne M. Hibl, Jennifer L. Spencer Clinton, Rebecca Rico-Hesse
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 6, p e0009427 (2021)
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases
Chikungunya virus (CHIKV) is an emerging, mosquito-borne alphavirus responsible for acute to chronic arthralgias and neuropathies. Although it originated in central Africa, recent reports of disease have come from many parts of the world, including t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c39711ea8a09e8292fa3544a8d892a17
https://doi.org/10.1371/journal.pntd.0009427
https://doi.org/10.1371/journal.pntd.0009427
Autor:
Jason T. Kimata, Linda L. Tran, David R. Rowley, Megan B. Vogt, Ravi P. Arya, Rebecca Rico-Hesse, Alexander R. Kneubehl, Daniela Xavier, Jennifer L Spencer, Anismrita Lahon
Publikováno v:
The Journal of Infectious Diseases. 217:538-547
Background While Zika virus (ZIKV) is mainly transmitted by mosquitoes, numerous cases of sexual transmission have been reported during recent outbreaks. Little is known about which host cell types or entry factors aid in mediating this sexual transm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf6354fe313ffc019000224915e8b36b
https://doi.org/10.1093/infdis/jix436
https://doi.org/10.1093/infdis/jix436