Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Rebecca R. Laposa"'
Autor:
Yuming Wang, Jace Jones-Tabah, Probir Chakravarty, Aengus Stewart, Alysson Muotri, Rebecca R. Laposa, Jesper Q. Svejstrup
Publikováno v:
Cell Reports, Vol 14, Iss 11, Pp 2554-2561 (2016)
Cockayne syndrome (CS) is a severe neurodevelopmental disorder characterized by growth abnormalities, premature aging, and photosensitivity. Mutation of Cockayne syndrome B (CSB) affects neuronal gene expression and differentiation, so we attempted t
Externí odkaz:
https://doaj.org/article/2a1fa791113c4b3e99e593e069351594
Autor:
Kathryn R. Cullen, Shehan M Fernando, Rebecca R. Laposa, Xinyang Zhou, Alexander Y. Pan, Bonnie Klimes-Dougan, Ana Cristina Andreazza
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 22
International Journal of Molecular Sciences, Vol 22, Iss 12513, p 12513 (2021)
Volume 22
Issue 22
International Journal of Molecular Sciences, Vol 22, Iss 12513, p 12513 (2021)
The NOD-, LRR-, and pyrin-domain-containing protein 3 (NLRP3) inflammasome is a node of intracellular stress pathways and a druggable target which integrates mitochondrial stress and inflammatory cascades. While a body of evidence suggests the involv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d317cefe330f792961c3024fcc36b913
Autor:
Rebecca R. Laposa, Dana Yehudai, Rose Hurren, Xiaoming Wang, Daina Avizonis, Gaëlle Bridon, Shrivani Sriskanthadevan, Aisha Shamas-Din, Mark D. Minden, Marcela Gronda, Veronique Voisin, Thirushi P. Siriwardena, Sanduni U. Liyanage, Changjiang Xu, Aaron D. Schimmer, Gary D. Bader, Neil MacLean
Publikováno v:
Blood. 129:2657-2666
Mitochondrial DNA (mtDNA) biosynthesis requires replication factors and adequate nucleotide pools from the mitochondria and cytoplasm. We performed gene expression profiling analysis of 542 human acute myeloid leukemia (AML) samples and identified 55
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a03ddb39984d3b6f5bdfce69409af1bc
https://doi.org/10.1182/blood-2016-10-741207
https://doi.org/10.1182/blood-2016-10-741207
Autor:
Sabina Smoleń, Yiqian Wenren, Pavla Perlíková, Noor-Ul-Ain Khalid, Barbora Lišková, Blanka Klepetářová, Ivo Frydrych, Petr Džubák, Anna Tokarenko, Michal Tichý, Soňa Gurská, Marian Hajduch, Michal Hocek, Helena Mertlíková-Kaiserová, Pawel Znojek, Natálie Táborská, Eva Tloušt’ová, Lenka Poštová Slavětínská, Rebecca R. Laposa, Radek Pohl
Publikováno v:
Journal of medicinal chemistry. 62(3)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d8314438b851e3b42a8f636cb2754cd
https://pubmed.ncbi.nlm.nih.gov/30281308
https://pubmed.ncbi.nlm.nih.gov/30281308
Autor:
Alysson R. Muotri, Probir Chakravarty, Jace Jones-Tabah, Yuming Wang, Rebecca R. Laposa, Aengus Stewart, Jesper Q. Svejstrup
Publikováno v:
Cell Reports
Cell Reports, Vol 14, Iss 11, Pp 2554-2561 (2016)
Cell Reports, Vol 14, Iss 11, Pp 2554-2561 (2016)
Summary Cockayne syndrome (CS) is a severe neurodevelopmental disorder characterized by growth abnormalities, premature aging, and photosensitivity. Mutation of Cockayne syndrome B (CSB) affects neuronal gene expression and differentiation, so we att
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0dbc4cc265418613247af4bb78dda86
https://doi.org/10.1016/j.celrep.2016.02.051
https://doi.org/10.1016/j.celrep.2016.02.051
Publikováno v:
Cancer Research. 80:6361-6361
Dysregulated metabolism is a hallmark of cancer and a substantial subset of many cancers rely on oxidative phosphorylation (OXPHOS) for growth and viability, including AML, breast cancer, lung cancer, glioblastoma, ovarian and pancreatic cancer. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::449a28bab5ea7a420223a6d33f97bf96
https://doi.org/10.1158/1538-7445.am2020-6361
https://doi.org/10.1158/1538-7445.am2020-6361
Autor:
Anna Tokarenko, Petr Džubák, Sabina Smoleń, Yiqian Wenren, Rebecca R. Laposa, Marian Hajduch, Noor-Ul-Ain Khalid, Soňa Gurská, Michal Tichý, Helena Mertlíková-Kaiserová, Pavla Perlíková, Barbora Lišková, Blanka Klepetářová, Eva Tloušt’ová, Ivo Frydrych, Natálie Táborská, Radek Pohl, Michal Hocek, Lenka Poštová Slavětínská, Pawel Znojek
Publikováno v:
Journal of Medicinal Chemistry
Three series of isomeric pyrrolo- and furo-fused 7-deazapurine ribonucleosides were synthesized and screened for cytostatic and antiviral activity. The synthesis was based on heterocyclizations of hetaryl-azidopyrimidines to form the tricyclic hetero
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::213346075a6778bef16bc04d7838a5c1
https://pubmed.ncbi.nlm.nih.gov/30681330
https://pubmed.ncbi.nlm.nih.gov/30681330
Publikováno v:
ACS Chemical Biology
Replication and maintenance of mitochondrial DNA (mtDNA) is essential for cellular function, yet few DNA polymerases are known to function in mitochondria. Here, we conclusively demonstrate that DNA polymerase θ (Polθ) localizes to mitochondria and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67118707d7d657b75771f51875115663
https://pubmed.ncbi.nlm.nih.gov/29509408
https://pubmed.ncbi.nlm.nih.gov/29509408
Autor:
Ana Cristina Andreazza, Leonardo Salmena, Aveline Tung, Francine B. Chingcuanco, Aaron D. Schimmer, Rose Hurren, Rebecca R. Laposa, Thomas A. Fung, Xiaoming Wang, Pamela Psarianos, Fernando N. Bralha, Meong Hi Son, Sanduni U. Liyanage
Publikováno v:
Oncotarget
Acute myeloid leukemia (AML) cells have high oxidative phosphorylation and mitochondrial mass and low respiratory chain spare reserve capacity. We reasoned that targeting the mitochondrial RNA polymerase (POLRMT), which indirectly controls oxidative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03f19993c298d048dfe6bb15a6ad038e
http://europepmc.org/articles/PMC4741925
http://europepmc.org/articles/PMC4741925
Autor:
Noel Southall, Danny V. Jeyaraju, Sanduni U. Liyanage, Yan Wu, Mark D. Minden, Paul A. Spagnuolo, Rose Hurren, Marcela Gronda, Samantha A. Hershenfeld, ManTek Yeung, Eric A. Lee, Carine R. Nemr, Rebecca R. Laposa, Wei Zheng, Aaron D. Schimmer, Catherine Z. Chen, Xiaoming Wang, Jeevan Augustine
Publikováno v:
Apoptosis. 20:811-820
Mitochondria contain multiple copies of their own 16.6 kb circular genome. To explore the impact of mitochondrial DNA (mtDNA) damage on mitochondrial (mt) function and viability of AML cells, we screened a panel of DNA damaging chemotherapeutic agent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00e718059dcc9f7e2e84d415a74ecfe2
https://doi.org/10.1007/s10495-015-1119-z
https://doi.org/10.1007/s10495-015-1119-z