Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Rebecca Penn"'
Autor:
Carol M. Sheppard, Daniel H. Goldhill, Olivia C. Swann, Ecco Staller, Rebecca Penn, Olivia K. Platt, Ksenia Sukhova, Laury Baillon, Rebecca Frise, Thomas P. Peacock, Ervin Fodor, Wendy S. Barclay
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Human ANP32A and ANP32B are essential but redundant host factors for influenza virus genome replication. While most influenza viruses cannot replicate in edited human cells lacking both ANP32A and ANP32B, some strains exhibit limited growth.
Externí odkaz:
https://doaj.org/article/9ea86ca4471f48e0947e131249f06d09
Autor:
Jesus Rodriguez-Manzano, Kenny Malpartida-Cardenas, Nicolas Moser, Ivana Pennisi, Matthew Cavuto, Luca Miglietta, Ahmad Moniri, Rebecca Penn, Giovanni Satta, Paul Randell, Frances Davies, Frances Bolt, Wendy Barclay, Alison Holmes, Pantelis Georgiou
Publikováno v:
ACS Central Science, Vol 7, Iss 2, Pp 307-317 (2021)
Externí odkaz:
https://doaj.org/article/57cf86dfe29044c2997719a7323420b9
Autor:
Paul F. McKay, Kai Hu, Anna K. Blakney, Karnyart Samnuan, Jonathan C. Brown, Rebecca Penn, Jie Zhou, Clément R. Bouton, Paul Rogers, Krunal Polra, Paulo J. C. Lin, Christopher Barbosa, Ying K. Tam, Wendy S. Barclay, Robin J. Shattock
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-7 (2020)
Here, the authors develop a self-amplifying RNA encoding the SARS-CoV-2 spike protein encapsulated within a lipid nanoparticle as a vaccine candidate and show induction of neutralization antibody titers in mice that are comparable to titers in conval
Externí odkaz:
https://doaj.org/article/d121c83855b64dc7847d5eded42ee84e
Publikováno v:
Viruses, Vol 14, Iss 2, p 441 (2022)
Involvement of macrophages in the SARS-CoV-2-associated cytokine storm, the excessive secretion of inflammatory/anti-viral factors leading to the acute respiratory distress syndrome (ARDS) in COVID-19 patients, is unclear. In this study, we sought to
Externí odkaz:
https://doaj.org/article/f6b36d52b6294a6395f90298adfdd622
Autor:
Brian Hanley, MBBCh, Kikkeri N Naresh, ProfMD, Candice Roufosse, PhD, Andrew G Nicholson, ProfDM, Justin Weir, FRCPath, Graham S Cooke, ProfFRCP, Mark Thursz, ProfMD, Pinelopi Manousou, PhD, Richard Corbett, PhD, Robert Goldin, ProfMD, Safa Al-Sarraj, ProfFRCPath, Alireza Abdolrasouli, PhD, Olivia C Swann, MRes, Laury Baillon, BSc, Rebecca Penn, MSc, Wendy S Barclay, ProfPhD, Patrizia Viola, MD, Michael Osborn, FRCPath
Publikováno v:
The Lancet Microbe, Vol 1, Iss 6, Pp e245-e253 (2020)
Summary: Background: Severe COVID-19 has a high mortality rate. Comprehensive pathological descriptions of COVID-19 are scarce and limited in scope. We aimed to describe the histopathological findings and viral tropism in patients who died of severe
Externí odkaz:
https://doaj.org/article/b910c056406e4a2cbe5e3619d204d092
Levels of Influenza A Virus Defective Viral Genomes Determine Pathogenesis in the BALB/c Mouse Model
Autor:
Rebecca Penn, John S. Tregoning, Katie E. Flight, Laury Baillon, Rebecca Frise, Daniel H. Goldhill, Cecilia Johansson, Wendy S. Barclay
Publikováno v:
Journal of Virology. 96
Defective viral genomes (DVGs), which are generated by the viral polymerase in error during RNA replication, can trigger innate immunity and are implicated in altering the clinical outcome of infection. Here, we investigated the impact of DVGs on inn
Autor:
Paul Moss, Peter Nightingale, Matthew K. O'Shea, Lorraine Harper, Rebecca Penn, Adam F. Cunningham, Nadezhda A. Wall, Dimitrios Chanouzas, Daniel Geh, Charlotte Jones, Alexandra Godlee, Sian E Faustini, Ruth Harvey, Alex G. Richter
Publikováno v:
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Background Patients with chronic kidney disease (CKD) are more prone to severe infection. Vaccination is a key strategy to reduce this risk. Some studies suggest vaccine efficacy may be reduced in patients with CKD, despite preserved maintenance of l
Autor:
Wendy S. Barclay, Frances Bolt, Jesus Rodriguez-Manzano, Kenny Malpartida-Cardenas, Alison Holmes, Luca Miglietta, Matthew L. Cavuto, Pantelis Georgiou, Giovanni Satta, Rebecca Penn, Nicolas Moser, Paul Randell, Ivana Pennisi, Frances Davies, Ahmad Moniri
Publikováno v:
ACS Central Science
ACS Central Science, Vol 7, Iss 2, Pp 307-317 (2021)
ACS Central Science, Vol 7, Iss 2, Pp 307-317 (2021)
The COVID-19 pandemic is a global health emergency characterized by the high rate of transmission and ongoing increase of cases globally. Rapid point-of-care (PoC) diagnostics to detect the causative virus, SARS-CoV-2, are urgently needed to identify
Involvement of macrophages in the SARS-CoV-2-associated cytokine storm, the excessive secretion of inflammatory/anti-viral factors leading to the acute respiratory distress syndrome (ARDS) in COVID-19 patients, is unclear. In this study, we sought to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5661d2fa9a82ebfaeafb38578fa40091
https://doi.org/10.1101/2022.02.02.478897
https://doi.org/10.1101/2022.02.02.478897
Autor:
Wendy S. Barclay, Mark Thursz, Rebecca Penn, Justin Weir, Patrizia Viola, Graham S Cooke, Andrew G. Nicholson, Candice Roufosse, Richard Corbett, Pinelopi Manousou, Robert D. Goldin, Laury Baillon, Safa Al-Sarraj, Olivia C. Swann, Alireza Abdolrasouli, Kikkeri N. Naresh, Michael Osborn, Brian Hanley
Publikováno v:
The Lancet Microbe
e253
e245
The Lancet. Microbe
The Lancet Microbe, Vol 1, Iss 6, Pp e245-e253 (2020)
e253
e245
The Lancet. Microbe
The Lancet Microbe, Vol 1, Iss 6, Pp e245-e253 (2020)
Summary: Background: Severe COVID-19 has a high mortality rate. Comprehensive pathological descriptions of COVID-19 are scarce and limited in scope. We aimed to describe the histopathological findings and viral tropism in patients who died of severe