Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Rebecca Nofsinger"'
Publikováno v:
Frontiers in Drug Discovery, Vol 4 (2024)
Externí odkaz:
https://doaj.org/article/fdb2b7ce2eb7476b9497be109388f4f2
Design of Prodrugs to Enhance Colonic Absorption by Increasing Lipophilicity and Blocking Ionization
Autor:
Rebecca Nofsinger, Sophie-Dorothee Clas, Rosa I. Sanchez, Abbas Walji, Kimberly Manser, Becky Nissley, Jaume Balsells, Amrithraj Nair, Qun Dang, David Jonathan Bennett, Michael Hafey, Junying Wang, John Higgins, Allen Templeton, Paul Coleman, Jay Grobler, Ronald Smith, Yunhui Wu
Publikováno v:
Pharmaceuticals, Vol 7, Iss 2, Pp 207-219 (2014)
Prodrugs are chemistry-enabled drug delivery modifications of active molecules designed to enhance their pharmacokinetic, pharmacodynamic and/or biopharmaceutical properties. Ideally, prodrugs are efficiently converted in vivo, through chemical or en
Externí odkaz:
https://doaj.org/article/f16659dde48e4fc4a5f8d5c963902bbd
Autor:
Ashley R. Johnson, Jeanine E. Ballard, Andrew Leithead, Corin Miller, Fried Faassen, Xiaowei Zang, Rebecca Nofsinger, Angela M. Wagner
Publikováno v:
Pharmaceutical Research.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9fa4f0d19d8aa16c51e757827bbc867c
https://doi.org/10.1007/s11095-023-03470-8
https://doi.org/10.1007/s11095-023-03470-8
Autor:
Alexandra K. Abel, Andre Hermans, Nathan Z. Dreger, Natasha C. Brigham, Rebecca Nofsinger, Xin Luo, Ru-Rong Ji, Tiffany P. Gustafson, Matthew L. Becker, Seth P. Forster
Publikováno v:
Journal of controlled release : official journal of the Controlled Release Society. 329
Medical prescriptions for the alleviation of post-surgical pain are the most abundant source of opioids in circulation. As a systemic drug delivery source, opioids leave patients at high risk for side effects after being dosed. Given the significant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e428ecd32da71089dd4f28ffbe57ba67
https://pubmed.ncbi.nlm.nih.gov/33278481
https://pubmed.ncbi.nlm.nih.gov/33278481
Autor:
Richard Tschirret-Guth, Caroline McGregor, Mark Cartwright, Michael D. Altman, Suman Mukherjee, Iain Martin, Alan B. Northrup, Pierre Daublain, Kung-I Feng, Rebecca Nofsinger
Publikováno v:
Molecular Pharmaceutics. 14:1634-1645
The purpose of this research was to assess variability in pharmacokinetic profiles (PK variability) in preclinical species and identify the risk factors associated with the properties of a drug molecule that contribute to the variability. Exposure da
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2a62ebcee6b50d075d33266387a1cf7
https://doi.org/10.1021/acs.molpharmaceut.6b01118
https://doi.org/10.1021/acs.molpharmaceut.6b01118
Autor:
Jianzhong Wen, Nicole Buist, Ying Li, Scott Fauty, Prajakta Gadgil, Marian E. Gindy, Alexei V. Buevich, Tomi K. Sawyer, Candice Alleyne, Mengwei Hu, Kung-I Feng, Gino Salituro, Rebecca Nofsinger
Publikováno v:
Pharmaceutical Research. 36
In this study we evaluated the utility of in-vitro screening tools for predicting the in-vivo behavior of six cyclic peptides with different solubility and permeability properties (BCS class II and III), intended for oral delivery in presence of perm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3aaa5891ad32051a85a09259c8b1610c
https://doi.org/10.1007/s11095-019-2682-8
https://doi.org/10.1007/s11095-019-2682-8
Autor:
Kendra Galipeau, Dorothy Levorse, Paul L. Walsh, Filippos Kesisoglou, Joyce Stellabott, Wei Xu, Rebecca Nofsinger
Publikováno v:
AAPS PharmSciTech. 18:1408-1416
Despite many documented differences in gut physiology compared to humans, the beagle dog has been successfully used as a preclinical model for assessing the relative bioavailability of dosage forms during formulation development. However, differences
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0318a6ce8d0196866a70991c1ecd7f1
https://doi.org/10.1208/s12249-016-0611-2
https://doi.org/10.1208/s12249-016-0611-2
Autor:
Paul J. Coleman, Becky Nissley, Allen C. Templeton, Yunhui Wu, Rosa I. Sanchez, Jaume Balsells, Jay A. Grobler, Sophie-Dorothee Clas, Michael J. Hafey, Junying Wang, Abbas Walji, Qun Dang, Rebecca Nofsinger, Jing Li, Manuel de Lera Ruiz, Gene Chessen, John M. Sanders, Christopher T. John, Amrithraj Bennet, John S. Wai, David Jonathan Bennett, Kimberly Manser, Christina N. Di Marco, Scott S. Ceglia, Somang Hope Kim, John Higgins, Ronald D. Smith
Publikováno v:
ChemMedChem. 10:245-252
Developing new antiretroviral therapies for HIV-1 infection with potential for less frequent dosing represents an important goal within drug discovery. Herein, we present the discovery of ethyl (1-((4-((4-fluorobenzyl)carbamoyl)-1-methyl-2-(2-(5-meth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc8eaf7e17f0b6021ac4c02ad8253c13
https://doi.org/10.1002/cmdc.201402393
https://doi.org/10.1002/cmdc.201402393
Design of Prodrugs to Enhance Colonic Absorption by Increasing Lipophilicity and Blocking Ionization
Autor:
Abbas Walji, Becky Nissley, Michael J. Hafey, Jay A. Grobler, Rosa I. Sanchez, Jaume Balsells, John Higgins, Allen C. Templeton, Ronald D. Smith, Paul J. Coleman, David Jonathan Bennett, Kimberly Manser, Qun Dang, Sophie-Dorothee Clas, Rebecca Nofsinger, Amrithraj Nair, Yunhui Wu, Junying Wang
Publikováno v:
Pharmaceuticals
Pharmaceuticals; Volume 7; Issue 2; Pages: 207-219
Pharmaceuticals, Vol 7, Iss 2, Pp 207-219 (2014)
Pharmaceuticals; Volume 7; Issue 2; Pages: 207-219
Pharmaceuticals, Vol 7, Iss 2, Pp 207-219 (2014)
Prodrugs are chemistry-enabled drug delivery modifications of active molecules designed to enhance their pharmacokinetic, pharmacodynamic and/or biopharmaceutical properties. Ideally, prodrugs are efficiently converted in vivo, through chemical or en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a82703542f99decf50128201918231f4
http://europepmc.org/articles/PMC3942693
http://europepmc.org/articles/PMC3942693
Publikováno v:
Drug Discovery Today. 19:79-87
Prodrugs can be used to enhance the properties of an active pharmaceutical ingredient or drug, generally by improving solubility and/or permeability of the compound. However, discovery teams duly spend considerable time and resources on structure-act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e74ec5d319f6c2239844b3ebbd84588a
https://doi.org/10.1016/j.drudis.2013.08.014
https://doi.org/10.1016/j.drudis.2013.08.014