Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Rebecca N. Nix"'
Autor:
Steven B. Kanner, Koc-Kan Ho, Michael V. McCullar, Marc O'Reilly, Kevin Wright, Scott Pearce, Xiao-Hui Liu, Michael Saunders, Yong Xu, Virgil McCarthy, Jihua Liu, David Vollmer, Anna Senina, Bai Luo, Jeremy Bullough, Adrianne Clifford, Rebecca N. Nix, Jason M. Foulks, K. Mark Parnell
Inactivation of the M2 form of pyruvate kinase (PKM2) in cancer cells is associated with increased tumorigenicity. To test the hypothesis that tumor growth may be inhibited through the PKM2 pathway, we generated a series of small-molecule PKM2 activa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1681cbb614c99d18db4a719f8206e70
https://doi.org/10.1158/1535-7163.c.6536250
https://doi.org/10.1158/1535-7163.c.6536250
Supplementary Figure Legends from Pharmacologic Activation of PKM2 Slows Lung Tumor Xenograft Growth
Autor:
Steven B. Kanner, Koc-Kan Ho, Michael V. McCullar, Marc O'Reilly, Kevin Wright, Scott Pearce, Xiao-Hui Liu, Michael Saunders, Yong Xu, Virgil McCarthy, Jihua Liu, David Vollmer, Anna Senina, Bai Luo, Jeremy Bullough, Adrianne Clifford, Rebecca N. Nix, Jason M. Foulks, K. Mark Parnell
Supplementary Figure Legends - PDF file 41K, Legends for supplemental figures 1-4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06832d9dfe0e27d733354edca60423ca
https://doi.org/10.1158/1535-7163.22499760
https://doi.org/10.1158/1535-7163.22499760
Autor:
Steven B. Kanner, Koc-Kan Ho, Michael V. McCullar, Marc O'Reilly, Kevin Wright, Scott Pearce, Xiao-Hui Liu, Michael Saunders, Yong Xu, Virgil McCarthy, Jihua Liu, David Vollmer, Anna Senina, Bai Luo, Jeremy Bullough, Adrianne Clifford, Rebecca N. Nix, Jason M. Foulks, K. Mark Parnell
Supplementary Figures 1-4 - PDF file 294K, Supplementary Figure 1: PKM2 activation by screening hit XC-409; Supplementary Figure 2: Phosphorylation state of PKM2 at Tyr105 in cancer cell lines; supplementary Figure 3: Viability of a selection of lung
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69a47597581c335365308895b32c34bb
https://doi.org/10.1158/1535-7163.22499757
https://doi.org/10.1158/1535-7163.22499757
Publikováno v:
PLoS ONE, Vol 5, Iss 2, p e9441 (2010)
Hemophagocytic lymphohistiocytosis (HLH) is a hyper-inflammatory clinical syndrome associated with neoplastic disorders especially lymphoma, autoimmune conditions, and infectious agents including bacteria, viruses, protozoa and fungi. In both human a
Externí odkaz:
https://doaj.org/article/9e014ef583df4154a48d9cfabdf98b96
Publikováno v:
PLoS Pathogens, Vol 3, Iss 12, p e193 (2007)
Salmonella enterica subspecies can establish persistent, systemic infections in mammals, including human typhoid fever. Persistent S. enterica disease is characterized by an initial acute infection that develops into an asymptomatic chronic infection
Externí odkaz:
https://doaj.org/article/4771aa819a444706a12e806367fe71ad
Autor:
David J. Bearss, Jared Bearss, Lee T. Call, Alexis Mollard, Shuping Lai, Steven L. Warner, Dan Albertson, Shannon Merx, Ashley Chan, Michael V. McCullar, Yong Xu, Rebecca N. Nix, Anna Senina, Marcus Wilkes, Ting Liu, Bret Stephens, Jason M. Foulks, Steven B. Kanner, David Vollmer, Kent J. Carpenter, Adrianne Clifford, Benjamin Brenning, Koc Kan Ho, Bai Luo, Sheryl R. Tripp
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 16, Iss 5, Pp 403-412 (2014)
Neoplasia (New York, N.Y.)
Neoplasia (New York, N.Y.)
The proto-oncogene proviral integration site for moloney murine leukemia virus (PIM) kinases (PIM-1, PIM-2, and PIM-3) are serine/threonine kinases that are involved in a number of signaling pathways important to cancer cells. PIM kinases act in down
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2152aee3dabac3beff14d5487b5fed47
Autor:
Xiao-Hui Liu, Hendrickson Thomas, Kevin Wright, Adrianne Clifford, Michael V. McCullar, Rebecca N. Nix, Steven B. Kanner, Michael Saunders, Jeremy Bullough, Jason M. Foulks, Yong Xu, Scott Pearce, K. Mark Parnell, Koc-Kan Ho
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:515-519
Activators of the pyruvate kinase M2 (PKM2) are currently attracting significant interest as potential anticancer therapies. They may achieve a novel antiproliferation response in cancer cells through modulation of the classic ‘Warburg effect’ ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87a8997aa61a17e2872460ed59236263
https://doi.org/10.1016/j.bmcl.2013.12.028
https://doi.org/10.1016/j.bmcl.2013.12.028
Autor:
Alfredo Cervantes, Miguel Gonzalez, Sandra Weigand, Timothy R. Geiger, Jennifer M. Martin, Christopher M. Wrobel, Aaron M. Robitaille, Rebecca N. Nix
Publikováno v:
Virus Research. 178:314-327
LMP-1 is a constitutively active Tumor Necrosis Factor Receptor analog encoded by Epstein-Barr virus. LMP-1 activation correlates with oligomerization and raft localization, but direct evidence of LMP-1 oligomers is limited. We report that LMP-1 form
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa282cbc8f325e83d2311ae9b2f5bc21
https://doi.org/10.1016/j.virusres.2013.09.025
https://doi.org/10.1016/j.virusres.2013.09.025
Autor:
Michael V. McCullar, K. Mark Parnell, Suzanna Chau, Steven B. Kanner, Kevin Wright, Rebecca N. Nix, Michael Saunders, Hendrickson Thomas, Jason M. Foulks, Koc-Kan Ho, K. Swierczek
Publikováno v:
SLAS Discovery. 17:2-17
Epigenetic modification of DNA leads to changes in gene expression. DNA methyltransferases (DNMTs) comprise a family of nuclear enzymes that catalyze the methylation of CpG dinucleotides, resulting in an epigenetic methylome distinguished between nor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a833daf40b0dd991b3190218bb6a5597
https://doi.org/10.1177/1087057111421212
https://doi.org/10.1177/1087057111421212
Autor:
Anna Senina, David Vollmer, Xiao-Hui Liu, Kevin Wright, Virgil McCarthy, Scott Pearce, Marc O'Reilly, Jason M. Foulks, K. Mark Parnell, Steven B. Kanner, Jihua Liu, Bai Luo, Jeremy Bullough, Koc-Kan Ho, Adrianne Clifford, Rebecca N. Nix, Michael Saunders, Yong Xu, Michael V. McCullar
Publikováno v:
Molecular cancer therapeutics. 12(8)
Inactivation of the M2 form of pyruvate kinase (PKM2) in cancer cells is associated with increased tumorigenicity. To test the hypothesis that tumor growth may be inhibited through the PKM2 pathway, we generated a series of small-molecule PKM2 activa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b90d2d6c90d134e7e9c28f8e4947900
https://pubmed.ncbi.nlm.nih.gov/23720766
https://pubmed.ncbi.nlm.nih.gov/23720766