Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Rebecca N. Douglas-Denton"'
Autor:
Victor G. Puelles, Jinhua Li, Michael D Hughson, John F. Bertram, Peter G. Kerr, Luise A. Cullen-McEwen, Wendy E. Hoy, Rebecca N. Douglas-Denton
Publikováno v:
Journal of the American Society of Nephrology. 26:2277-2288
Increases in glomerular size occur with normal body growth and in many pathologic conditions. In this study, we determined associations between glomerular size and numbers of glomerular resident cells, with a particular focus on podocytes. Kidneys fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78b48dec57ba016edfeafff5ef70942a
https://doi.org/10.1681/asn.2014070641
https://doi.org/10.1681/asn.2014070641
Autor:
Victor G. Puelles, Wendy E. Hoy, Susan A. Mott, Michael D Hughson, John F. Bertram, Rebecca N. Douglas-Denton
Publikováno v:
Nephrology Dialysis Transplantation
Background African Americans have more severe hypertensive nephrosclerosis than white Americans, possibly at similar levels of blood pressure. Glomerular volume is increased in African Americans relative to whites, but it is uncertain how this relate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17e2602f6e94f11f3a6ab74098ce9a05
http://europepmc.org/articles/PMC4071048
http://europepmc.org/articles/PMC4071048
Publikováno v:
Pediatric Nephrology. 26:1529-1533
Several studies have shown that total nephron (glomerular) number varies widely in normal human kidneys. Whereas the studies agree that average nephron number is approximately 900,000 to 1 million per kidney, numbers for individual kidneys range from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18ea2059aed5bf35d0c32e4b5c97b950
https://doi.org/10.1007/s00467-011-1843-8
https://doi.org/10.1007/s00467-011-1843-8
Autor:
Rebecca N. Douglas-Denton, Victor G. Puelles, Boucar Diouf, Michael D Hughson, John F. Bertram, Wendy E. Hoy
Publikováno v:
Current Opinion in Nephrology and Hypertension. 20:7-15
This review discusses current understandings of variability in glomerular number and size, and the implications for renal health.The quantitative microanatomy of the normal human kidney varies widely. Of greatest significance, total nephron number va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b0d02b6801d0801b9bacc9c4f57a2ed
https://doi.org/10.1097/mnh.0b013e3283410a7d
https://doi.org/10.1097/mnh.0b013e3283410a7d
Autor:
Michael D Hughson, Libby Holden, John F. Bertram, Susan A. Mott, Bridgette McNamara, Wendy E. Hoy, Terence Samuel, Rebecca N. Douglas-Denton, Boucar Diouf, Monika A. Zimanyi
Publikováno v:
American Journal of Nephrology. 33:15-20
We have demonstrated considerable variability in the volumes of different glomeruli in given individuals (individual glomerular volume: IGV) in a stereologic study of kidneys at forensic autopsy performed to investigate sudden or unexpected death in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3b40da0af841286dde9c749f20bf795
https://doi.org/10.1159/000327044
https://doi.org/10.1159/000327044
Autor:
Wendy E. Hoy, Michael D Hughson, John F. Bertram, Monika A. Zimanyi, Rebecca N. Douglas-Denton
Publikováno v:
Nephrology Dialysis Transplantation
Background. Glomerulomegaly, the abnormal enlargement of glomeruli, has been related to an increased risk of glomerulosclerosis, but the degree of enlargement that constitutes glomerulomegaly has not been defined. Methods. The principal stereological
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3100a5c1bc2f069f63c758edc612348e
https://doi.org/10.1093/ndt/gfq688
https://doi.org/10.1093/ndt/gfq688
Publikováno v:
Monash University
Low nephron number has been related to low birth weight and hypertension. In the southeastern United States, the estimated prevalence of chronic kidney disease due to hypertension is five times greater for African Americans than white subjects. This
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65da2c276272b5edb72c7d51c5371d9d
Autor:
Michael D Hughson, John F. Bertram, Wendy E. Hoy, Kelli Johnson, Rebecca N. Douglas-Denton, Alan Cass
Publikováno v:
Kidney International. 63:S31-S37
A stereological study of glomerular number and volume: Pre- As for all other biologic variables, it is likely there is liminary findings in a multiracial study of kidneys at autopsy. substantial variation in glomerular (nephron) number Background. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36cb16cc981ba6d52271732bad9e5539
Publikováno v:
Endocrinology. 143:4455-4463
Ovine fetuses exposed to high concentrations of synthetic (dexamethasone, D) or naturally occurring glucocorticoids (cortisol, F) in utero during early gestation develop high blood pressure in adulthood. To investigate potential mechanisms involved,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::782bf97a6ca8cbb36b558135c4ebef6f
https://doi.org/10.1210/en.2002-220534
https://doi.org/10.1210/en.2002-220534
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 283:R972-R982
In sheep, placental size is maximal by midgestation, but blood flow continues to increase until term. No nerves are present and ANG II is thought to be a major regulator of vascular tone. We hypothesized that angiotensin type 2 receptors (AT2) would
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0baf387f5f02039af8b61ff19fdfb474
https://doi.org/10.1152/ajpregu.00070.2002
https://doi.org/10.1152/ajpregu.00070.2002