Disruption of the Pseudomonas aeruginosa Tat system perturbs PQS-dependent quorum sensing and biofilm maturation through lack of the Rieske cytochrome bc1 sub-unit.

Autor: Eliza Ye-Chen Soh, Frances Smith, Maxime Rémi Gimenez, Liang Yang, Rebecca Munk Vejborg, Matthew Fletcher, Nigel Halliday, Sophie Bleves, Stephan Heeb, Miguel Cámara, Michael Givskov, Kim R Hardie, Tim Tolker-Nielsen, Bérengère Ize, Paul Williams

Publikováno v: PLoS Pathogens, Vol 17, Iss 8, p e1009425 (2021)

Extracellular DNA (eDNA) is a major constituent of the extracellular matrix of Pseudomonas aeruginosa biofilms and its release is regulated via pseudomonas quinolone signal (PQS) dependent quorum sensing (QS). By screening a P. aeruginosa transposon

Externí odkaz: https://doaj.org/article/ce7b17d113d34780b5ebc660479779e2

A broad range quorum sensing inhibitor working through sRNA inhibition

Autor: Joana A. Moscoso, Paal Skytt Andersen, Morten Rybtke, Tim Tolker-Nielsen, Tim Holm Jakobsen, Rico Petersen, Alain Filloux, Thomas E. Nielsen, Rebecca Munk Vejborg, Frederik Lorenzen, Michael Givskov, Anders N. Warming, Hanne Ingmer, Marc Stegger, Jens Bo Andersen

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Jakobsen, T H, Warming, A N, Vejborg, R M, Moscoso, J A, Stegger, M, Lorenzen, F, Rybtke, M, Andersen, J B, Petersen, R, Andersen, P S, Nielsen, T E, Tolker-Nielsen, T, Filloux, A, Ingmer, H & Givskov, M 2017, ' A broad range quorum sensing inhibitor working through sRNA inhibition ', Scientific Reports, vol. 7, no. 1, 9857 . https://doi.org/10.1038/s41598-017-09886-8
Jakobsen, T H, Warming, A N, Vejborg, R M, Moscoso, J A, Stegger, M, Lorenzen, F, Rybtke, M T, Andersen, J B, Petersen, R, Andersen, P S, Nielsen, T E, Tolker-Nielsen, T, Filloux, A, Ingmer, H & Givskov, M 2017, ' A broad range quorum sensing inhibitor working through sRNA inhibition ', Scientific Reports, vol. 7, no. 1, pp. 9857 . https://doi.org/10.1038/s41598-017-09886-8
Scientific Reports

For the last decade, chemical control of bacterial virulence has received considerable attention. Ajoene, a sulfur-rich molecule from garlic has been shown to reduce expression of key quorum sensing regulated virulence factors in the opportunistic pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80d18e7bfa1f73a93a976304d23c0d3e
https://doi.org/10.1038/s41598-017-09886-8

Identification of Genes Important for Growth of Asymptomatic Bacteriuria Escherichia coli in Urine

Autor: Mark A. Schembri, Rebecca Munk Vejborg, Minh-Duy Phan, Makrina Totsika, Mari Cristina Rodriguez de Evgrafov, Viktoria Hancock

Publikováno v: Infection and Immunity. 80:3179-3188

Escherichia coli is the most important etiological agent of urinary tract infections (UTIs). Unlike uropathogenic E. coli , which causes symptomatic infections, asymptomatic bacteriuria (ABU) E. coli strains typically lack essential virulence factors

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a50a03e46e0fd0ac0ff5f914e1379586
https://doi.org/10.1128/iai.00473-12

Cellular chain formation in Escherichia coli biofilms

Autor: Rebecca Munk Vejborg, Per Klemm

Publikováno v: Microbiology. 155:1407-1417

In this study we report on a novel structural phenotype in Escherichia coli biofilms: cellular chain formation. Biofilm chaining in E. coli K-12 was found to occur primarily by clonal expansion, but was not due to filamentous growth. Rather, chain fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e9fe8e940aa4d7250b79175e4083492
https://doi.org/10.1099/mic.0.026419-0

Bacterial adhesion to stainless steel is reduced by aqueous fish extract coatings

Autor: Nete Bernbom, R. L. Jørgensen, Peter Kingshott, Rikke Louise Meyer, Rebecca Munk Vejborg, Yoke Yin Ng, Flemming Besenbacher, Per Klemm, Lone Gram

Publikováno v: Bernbom, N, Jørgensen, R L, Meyer, R L, Ng, Y Y, Kingshott, P, Vejborg, R M, Klemm, P, Besenbacher, F & Gram, L 2006, ' Bacterial adhesion to stainless steel is reduced by aqueous fish extract coatings ', Biofilms, vol. 3, pp. 25-36 .

Microbial adhesion and biofilm formation on surfaces pose major problems and risks to human health. One way to circumvent this problem is to coat surfaces (in this report stainless steel) with a non-toxic fish extract that generates an abiotic surfac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e6f19eb1c4831dcb54d118e17a2fe73
https://doi.org/10.1017/s1479050507002104