Genetics of SLE: Functional Relevance for Monocytes/Macrophages in Disease

Autor: Jennifer C. Byrne, Joan Ní Gabhann, Elisa Lazzari, Rebecca Mahony, Siobhán Smith, Kevin Stacey, Claire Wynne, Caroline A. Jefferies

Publikováno v: Clinical and Developmental Immunology, Vol 2012 (2012)

Genetic studies in the last 5 years have greatly facilitated our understanding of how the dysregulation of diverse components of the innate immune system contributes to pathophysiology of SLE. A role for macrophages in the pathogenesis of SLE was fir

Externí odkaz: https://doaj.org/article/2126a4e9a9064fe8a8904e35fda5ea07

Physical activity levels and self-determined motivation among future healthcare professionals: Utility of the Behavioral Regulation in Exercise Questionnaire (BREQ-2)

Autor: Rebecca Mahony, Caitriona Cunningham, Grainne O' Donnoghue, James Matthews, Catherine Blake

Publikováno v: Physiotherapy Theory and Practice. 35:884-890

Background: Healthcare professionals (HCPs) who are physically active are regarded as more likely to act as credible physical activity (PA) role models and promote healthy lifestyles. This study explores PA levels and underlying motivations, within a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2d95feab253850c03c9afc4320cb642
https://doi.org/10.1080/09593985.2018.1457112

The RNA binding protein La/SS-B promotes RIG-I-mediated type I and type III IFN responses following Sendai viral infection

Autor: Ultan F. Power, Caroline A. Jefferies, Jacen S. Maier-Moore, Rebecca Mahony, Lindsay Broadbent

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Mahony, R, Broadbent, L, Maier-Moore, J S, Power, U F & Jefferies, C A 2017, ' The RNA binding protein La promotes RIG-I-mediated type I and type III IFN responses following Sendai viral infection ', Scientific Reports, vol. 7, 14537 . https://doi.org/10.1038/s41598-017-15197-9
Scientific Reports

La/SS-B (or La) is a 48 kDa RNA-binding protein and an autoantigen in autoimmune disorders such as systemic lupus erythematosus (SLE) and Sjögren’s syndrome (SS). La involvement in regulating the type I interferon (IFN) response is controversial -

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02210e27e3c3ed007e50e4de8d5f1943
https://doi.org/10.1038/s41598-017-15197-9

A novel anti-viral role for STAT3 in IFN-α signalling responses

Autor: Cliona O'Farrelly, Rebecca Mahony, Nigel J. Stevenson, Siobhan Gargan, Andrew G. Bowie, Kim L. Roberts, Sinead E. Keating, Nollaig M. Bourke

Publikováno v: Cellular and molecular life sciences : CMLS. 74(9)

The cytokine, Interferon (IFN)-α, induces a wide spectrum of anti-viral mediators, via the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway. STAT1 and STAT2 are well characterised to upregulate IFN-stimulated gene (IS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6596475e5b6e5bb5cbd01dd718c01723
https://pubmed.ncbi.nlm.nih.gov/27988795

Estrogen receptor α regulates tripartite motif-containing protein 21 expression, contributing to dysregulated cytokine production in systemic lupus erythematosus

Autor: Siobhán, Smith, Joan, Ní Gabhann, Eoghan, McCarthy, Barbara, Coffey, Rebecca, Mahony, Jennifer C, Byrne, Kevin, Stacey, Elizabeth, Ball, Aubrey, Bell, Gaye, Cunnane, Michele F, Doran, Eamonn S, Molloy, Ruth Z, Lee, Brian, Harvey, Grainne, Kearns, Caroline A, Jefferies

Publikováno v: Arthritisrheumatology (Hoboken, N.J.). 66(1)

To examine the role of 17β-estradiol in the regulation of the autoantigen tripartite motif-containing protein 21 (TRIM-21) in patients with systemic lupus erythematosus (SLE).Monocytes isolated from healthy control subjects and patients with SLE wer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2a0ce63d415d685d221fa5916e0bc983
https://pubmed.ncbi.nlm.nih.gov/24449583