Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Rebecca Mahony"'
Autor:
Siobhan Gargan, Suaad Ahmed, Rebecca Mahony, Ciaran Bannan, Silvia Napoletano, Cliona O'Farrelly, Persephone Borrow, Colm Bergin, Nigel J. Stevenson
Publikováno v:
EBioMedicine, Vol 30, Iss , Pp 203-216 (2018)
Anti-retroviral therapy successfully suppresses HIV-1 infection, but fails to provide a cure. During infection Type 1 IFNs normally play an essential role in viral clearance, but in vivo IFN-α only has a modest impact on HIV-1 infection, suggesting
Externí odkaz:
https://doaj.org/article/4e349b0e6bbb45a4be1ab20bcf442f6a
Autor:
Jennifer C. Byrne, Joan Ní Gabhann, Elisa Lazzari, Rebecca Mahony, Siobhán Smith, Kevin Stacey, Claire Wynne, Caroline A. Jefferies
Publikováno v:
Clinical and Developmental Immunology, Vol 2012 (2012)
Genetic studies in the last 5 years have greatly facilitated our understanding of how the dysregulation of diverse components of the innate immune system contributes to pathophysiology of SLE. A role for macrophages in the pathogenesis of SLE was fir
Externí odkaz:
https://doaj.org/article/2126a4e9a9064fe8a8904e35fda5ea07
Autor:
Fionnuala M. McAuliffe, Sarah L. Doyle, Ema Ozaki, Bobby D O'Leary, Alison McHugh, Rebecca Mahony, Danielle Mc Laughlin, Eleanor J. Molloy, Aoife M. Ryan, Aine Ni Chianain, Andrew E. Hogan, Sri Paran, Emma Connolly, Kelly Mulfaul, David N. O’Driscoll, Kiva Brennan, Nusrat Ali, Eamon P. Breen
Publikováno v:
The Journal of Immunology. 201:1131-1143
Two million infants die each year from infectious diseases before they reach 12 mo; many of these diseases are vaccine preventable in older populations. Pattern recognition receptors represent the critical front-line defense against pathogens. Eviden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::052869a2d775dded502fe6f0c661d991
https://doi.org/10.4049/jimmunol.1700956
https://doi.org/10.4049/jimmunol.1700956
Publikováno v:
Physiotherapy Theory and Practice. 35:884-890
Background: Healthcare professionals (HCPs) who are physically active are regarded as more likely to act as credible physical activity (PA) role models and promote healthy lifestyles. This study explores PA levels and underlying motivations, within a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2d95feab253850c03c9afc4320cb642
https://doi.org/10.1080/09593985.2018.1457112
https://doi.org/10.1080/09593985.2018.1457112
Autor:
Suaad Ahmed, Nigel J. Stevenson, Silvia Napoletano, Colm Bergin, Persephone Borrow, Rebecca Mahony, Cliona O'Farrelly, Siobhan Gargan, Ciaran Bannan
Publikováno v:
EBioMedicine, Vol 30, Iss, Pp 203-216 (2018)
EBioMedicine
EBioMedicine
Anti-retroviral therapy successfully suppresses HIV-1 infection, but fails to provide a cure. During infection Type 1 IFNs normally play an essential role in viral clearance, but in vivo IFN-α only has a modest impact on HIV-1 infection, suggesting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baa4be20654dd3d8c7f550613e2a2e7f
http://www.sciencedirect.com/science/article/pii/S2352396418300902
http://www.sciencedirect.com/science/article/pii/S2352396418300902
Autor:
Ultan F. Power, Caroline A. Jefferies, Jacen S. Maier-Moore, Rebecca Mahony, Lindsay Broadbent
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Mahony, R, Broadbent, L, Maier-Moore, J S, Power, U F & Jefferies, C A 2017, ' The RNA binding protein La promotes RIG-I-mediated type I and type III IFN responses following Sendai viral infection ', Scientific Reports, vol. 7, 14537 . https://doi.org/10.1038/s41598-017-15197-9
Scientific Reports
Mahony, R, Broadbent, L, Maier-Moore, J S, Power, U F & Jefferies, C A 2017, ' The RNA binding protein La promotes RIG-I-mediated type I and type III IFN responses following Sendai viral infection ', Scientific Reports, vol. 7, 14537 . https://doi.org/10.1038/s41598-017-15197-9
Scientific Reports
La/SS-B (or La) is a 48 kDa RNA-binding protein and an autoantigen in autoimmune disorders such as systemic lupus erythematosus (SLE) and Sjögren’s syndrome (SS). La involvement in regulating the type I interferon (IFN) response is controversial -
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02210e27e3c3ed007e50e4de8d5f1943
https://doi.org/10.1038/s41598-017-15197-9
https://doi.org/10.1038/s41598-017-15197-9
Autor:
Grainne Kearns, Rebecca Mahony, Eoghan M. McCarthy, Siobhán Smith, Kevin Stacey, Brian J. Harvey, Elizabeth Ball, Caroline A. Jefferies, Michele F. Doran, Jennifer C. Byrne, Ruth Z Lee, Eamonn S. Molloy, Barbara M. Coffey, Joan Ní Gabhann, Gaye Cunnane, Aubrey L. Bell
Publikováno v:
Arthritis & Rheumatology. 66:163-172
Objective To examine the role of 17β-estradiol in the regulation of the autoantigen tripartite motif–containing protein 21 (TRIM-21) in patients with systemic lupus erythematosus (SLE). Methods Monocytes isolated from healthy control subjects and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38b3fce55f13baf671823524a80563fe
https://doi.org/10.1002/art.38187
https://doi.org/10.1002/art.38187
Autor:
Cliona O'Farrelly, Rebecca Mahony, Nigel J. Stevenson, Siobhan Gargan, Andrew G. Bowie, Kim L. Roberts, Sinead E. Keating, Nollaig M. Bourke
Publikováno v:
Cellular and molecular life sciences : CMLS. 74(9)
The cytokine, Interferon (IFN)-α, induces a wide spectrum of anti-viral mediators, via the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway. STAT1 and STAT2 are well characterised to upregulate IFN-stimulated gene (IS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6596475e5b6e5bb5cbd01dd718c01723
https://pubmed.ncbi.nlm.nih.gov/27988795
https://pubmed.ncbi.nlm.nih.gov/27988795
Publikováno v:
Cellular and molecular life sciences : CMLS. 73(17)
Since their discovery, SOCS have been characterised as regulatory cornerstones of intracellular signalling. While classically controlling the JAK/STAT pathway, their inhibitory effects are documented across several cascades, underpinning their essent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::178ec1862f46e36a1c75f6d233b38313
https://pubmed.ncbi.nlm.nih.gov/27137184
https://pubmed.ncbi.nlm.nih.gov/27137184